Effect of Deuterium Oxide on the Culturing of Penicillium janczewskii II.

Nona, Daniel A.; Blake, Martin I.; Crespi, Henry L.; Katz, Joseph

doi:10.1002/jps.2600570611

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…The inclusion of 2H-substrates in the culture medium is necessary if additional deuterium atoms are to be incorporated into this molecule. Nona et al (4) and Mrtek et af. ( 5 ) utilized 2H-substrates to produce deuterated griseofulvin and ergot alkaloids, respectively.…”

Section: Resultsmentioning

confidence: 96%

Biosynthesis of Deuterated Benzylpenicillins II: Isolation and Characterization of a Highly Deuterated Benzylpenicillin

Carlstedt¹,

Crespi

Blake

et al. 1971

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 96%

Biosynthesis of Deuterated Benzylpenicillins II: Isolation and Characterization of a Highly Deuterated Benzylpenicillin

Carlstedt¹,

Crespi

Blake

et al. 1971

Journal of Pharmaceutical Sciences

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“…Antibacterial and antifungal activities were performed as per the procedures cited in the literature [35][36][37] .…”

Section: Antibacterial and Antifungal Activitymentioning

confidence: 99%

Antimicrobial Activity of Curcumin and Deuterated Curcumin

Anjana

Kathiravan

2022

JNR

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Deuterium (D) and hydrogen (H) are bioisosteres because they are similar in size and shape with alike physiochemical properties and hence expect similar biological activity. The purpose of replacing H with D is to extend the time the active drug species spends in plasma, resulting in increased effectiveness and/or the avoidance of unwanted side effects. Deutetrabenazine was the first deuterated medicinal molecule, recently authorized by the FDA for the treatment of chorea “an involuntary movement disorder” associated with tardive dyskinesia and Huntington’s disease. Curcumin is found to have a long history of use in human disorders such as inflammation, metabolic syndrome, arthritis, anxiety, antimicrobial, hyperlipidemia, etc., Curcumin’s oral bioavailability and water solubility are low, resulting in poor absorption, rapid metabolism, and systemic elimination. To overcome curcumin’s drawbacks, H/D exchange was performed in curcumin, which was then characterized and tested for antibacterial, antifungal, and anti-tubercular activities. The deuterated compound showed equipotent antibacterial activity when compared with the non-deuterated compound and had better anti-fungal, anti-tubercular activity compared to its parent compound.

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“…Nona et al ( 3 ) studied the effect of deuterium oxide on the culturing of Penicillium janczewskii and the antifungal activity of fully deuteriated griseofulvin. In an earlier report, Mohammed et al (4) investigated the effect on the growth and antibiotic production of a number of low producing strains of Penicillium.…”

mentioning

confidence: 99%