2-Substituted-3-(4-bromo-2-carboxyphenyl)-5-methyl-4-thiazolidinones as potential anti-inflammatory agents

Métodos de obtenção, reatividade e importância biológica de 4-tiazolidinonas

“…As atividades antiinflamatória e analgésica têm sido descritas em diversos trabalhos recentemente desenvolvidos para 4-tiazolidinonas. Goel e colaboradores 60 obtiveram excepcional resultado para uma das 3-(4-bromo-2-carbo-xifenil)-5-metil-4-tiazolidinonas 2-substituídas testadas sobre a redução de edema (induzido por carragenina) em ratos albinos, utilizando como fármaco padrão a fenilbutazona (Figura 5f). Em 1991, Walsh e colaboradores 61 descreveram a ação antiinflamatória e patentearam processos de síntese envolvendo mais de 80 derivados contendo o heterociclo 4-tiazolidinona, relatando a atuação destes compostos como inibidores das enzimas cicloxigenase e 5-lipoxigenase.…”

Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives

“…Additionally, fluorinated drug candidates increase binding affinity to target protein 12 . Likewise, bromine-substituted analogues also show better anti-inflammatory 13 activity. There are reports that dihalogen-substituted compounds exhibit superior biological activity 10,14 and only one heterocyclic compound substituted with 3-bromo-4--fluoro phenyl ring is reported as potent analgesic used in neuropathic and inflammatory pain 15 .…”

Synthesis, Characterisation, Antimicrobial Evaluation of 2-Hydroxy Phenyl Thiazolidine-4-One Derivative

“…Azetidinone and Thiazolidinone derivatives were reported to possess antibacterial [1][2] , antifungal [1][2] , antitumor [3] antituberculor activity [4] , anti-HIV [5] , analgesic [6] , anti inflammatory [6] , and ulcerogenic activity [7] . Pyridine derivatives were reported to possess antimicrobial [8] activities.…”