Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives

Chawla, Gita; Kumar, Umesh; Bawa, Sandhya; Kumar, J. Kranthi

doi:10.3109/14756366.2011.606543

Cited by 25 publications

(13 citation statements)

References 39 publications

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“…Chawla et al reported the syntheses and evaluation of 2-(3-bromo4-fluorophenyl)-5-substituted-1,3,4-oxadiazoles as anti-inflammatory agent. 16 The pharmacological results revealed that, compound 16 ( Figure 14) in which aryl ring was replaced by naphthyl ring, showed highest anti-inflammatory activity. Durgashivaprasad et al had explored the anti-inflammatory activity in acute and chronic models of two novel terium tuberculosis H37Rv and isoniazid resistant M. tuberculosis.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Recent Developments on Pharmacological Potential of 1,3,4-Oxadiazole Scaffold

Bhutani¹,

P²,

Kapoor³

et al. 2019

IJPER

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Recent Developments on Pharmacological Potential of 1,3,4-Oxadiazole Scaffold

Bhutani¹,

P²,

Kapoor³

et al. 2019

IJPER

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“…[3] Similarly, triazolo thiadiazoles are an important class of fused heterocyclic ring system being studied for a wide range of pharmacological activities. [8][9][10][11][12][13] The triazolo thiadiazole system can be considered as a cyclic analogue of thiosemicarbazide and biguanide which exhibit diverse biological activity. [14] Many analogues of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles have been reported for their anti-cancer activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of novel 1,2,4‐triazolo‐[3,4‐b]‐1,3,4‐thiadiazole tethered chalcone hybrids as potential anticancer agents

Bujji

Edigi

Subhashini

2020

Journal of Heterocyclic Chem

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A series of novel 1,2,4‐triazolo‐[3,4‐b]‐1,3,4‐thiadiazole tethered chalcone derivatives were designed synthesized by using conventional as well as microwave assisted methods and characterized by 1H NMR, 13C NMR and mass spectral analysis. Microwave assisted synthesis caused an improvement in yield and significant reduction in the reaction time of all the derivatives. All the new synthesized derivatives were further evaluated for their anti‐cancer activity against selected four human cancer cell lines; A549 (Lung), MCF‐7 (Breast), Colo‐205 (Colon) and A2780 (Ovarian). Among the synthesized compounds, 7b, 7c, 7d, 7e, 7g and 7h exhibited potent anticancer activity compared to control drug (etoposide).

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“…Being azoles, both 1,2,4‐triazoles and 1,3,4‐thiadiazole individually have their own importance in the field of medicinal chemistry, agriculture as well as industrial applications. Triazolo‐thiadiazole, fused product of 1,2,4‐triazole and 1,3,4‐thiadiazole are renowned heterocycles due to their versatile therapeutical applications such as antimicrobial,, anti‐inflammatory, analgesic, antibacterial, anti‐oxidant,,, antifungal, anticancer, anthelmintic, anti‐HIV, antitumor and anti‐tubercular . Triazolo‐thiadiazole derivatives reported to possess the CNS stimulant properties and anti‐hyperglycemic activity .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antimicrobial Evaluation and Docking Study of Some Pyrazole Bearing [1, 2,4]Triazolo[3, 4‐b][1, 3,4]thiadiazole Derivatives

Shingare¹,

Patil²,

Sangshetti³

et al. 2018

ChemistrySelect

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A novel series of pyrazole bearing [1,2,4]triazolo [3, 4-b] [1,3,4] thiadiazole derivatives (6 a-l) such as 3-(5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-3-yl)-6-(2-methoxyphenyl)- [1,2,4]triazolo [3, 4-b] [1,3,4]thiadiazole were synthesized by cyclo-condensation of 4-amino-5-[5-(3-fluoro-4-methoxy-phenyl)-1H-pyrazol-3yl]-4H-[1, 2,4]triazole-3-thiol (5) with substituted benzoic/pyridinyl acids in phosphorus oxychloride giving good yields and purity. IR, 1 H NMR, 13 C NMR and LCMS/MS spectroscopy were used to characterise all the synthesized compounds. All the new derivatives were appraised for their antimicrobial activity, antifungal assay against C. Albicans, A. Niger and A. Clavatus along with Nystatin and Griseofulvin as standard drug and antibacterial assay against E. Coli, P. Aeruginosa, S. Aureus, S. Pyogenus along with Ampicillin as standard drug. Compounds (6 b) and (6 j) displayed excellent antifungal activity whereas compound (6 d) and (6 e) displayed excellent antibacterial activity. Molecular modelling and adsorption, distribution, metabolism and excretion-toxicity (ADMET) prediction data clearly shows that 1,2,4-triazolo[3, 4-b][1, 3,4] thiadiazole derivatives (6 a-l) have potential to explore in the drug discovery pipeline as antifungal agents.

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Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives

Cited by 25 publications

References 39 publications

Recent Developments on Pharmacological Potential of 1,3,4-Oxadiazole Scaffold

Recent Developments on Pharmacological Potential of 1,3,4-Oxadiazole Scaffold

Synthesis and evaluation of novel 1,2,4‐triazolo‐[3,4‐b]‐1,3,4‐thiadiazole tethered chalcone hybrids as potential anticancer agents

Synthesis, Antimicrobial Evaluation and Docking Study of Some Pyrazole Bearing [1, 2,4]Triazolo[3, 4‐b][1, 3,4]thiadiazole Derivatives

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