Synthesis, Characterisation, Antimicrobial Evaluation of 2-Hydroxy Phenyl Thiazolidine-4-One Derivative

Ramachandran, S.

doi:10.20959/wjpps20178-9673

Cited by 2 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, which showed high and specific action against Mycobacterium tuberculosis [ 9 ]. Later, many thiazolidine derivatives were synthesized and evaluated for their antimicrobial effect [ 10 , 11 , 12 ]. It was shown that the antimicrobial effects are in close correlation with the nature and position of substituents on the heterocycle.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of New Polymeric Systems Based on Chitosan and Xanthine Derivatives with Thiazolidin-4-One Scaffold

et al. 2019

View full text Add to dashboard Cite

In the past many research studies have focused on the thiazolidine-4-one scaffold, due to the important biological effects associated with its heterocycle. This scaffold is present in the structure of many synthetic compounds, which showed significant biological effects such as antimicrobial, antifungal, antioxidant, anti-inflammatory, analgesic, antidiabetic effects. It was also identified in natural compounds, such as actithiazic acid, isolated from Streptomyces strains. Starting from this scaffold new xanthine derivatives have been synthetized and evaluated for their antibacterial and antifungal effects. The antibacterial action was investigated against Gram positive (Staphyloccoccus aureus ATCC 25923, Sarcina lutea ATCC 9341) and Gram negative (Escherichia coli ATCC 25922) bacterial strains. The antifungal potential was investigated against Candida spp. (Candida albicans ATCC 10231, Candida glabrata ATCC MYA 2950, Candida parapsilosis ATCC 22019). In order to improve the antimicrobial activity, the most active xanthine derivatives with thiazolidine-4-one scaffold (XTDs: 6c, 6e, 6f, 6k) were included in a chitosan based polymeric matrix (CS). The developed polymeric systems (CS-XTDs) were characterized in terms of morphological (aspect, particle size), physic-chemical properties (swelling degree), antibacterial and antifungal activities, toxicity, and biological functions (bioactive compounds loading, entrapment efficiency). The presence of xanthine-thiazolidine-4-one derivatives into the chitosan matrix was confirmed using Fourier transform infrared (FT-IR) analysis. The size of developed polymeric systems, CS-XTDs, ranged between 614 µm and 855 µm, in a dry state. The XTDs were encapsulated into the chitosan matrix with very good loading efficiency, the highest entrapment efficiency being recorded for CS-6k, which ranged between 87.86 ± 1.25% and 93.91 ± 1.41%, depending of the concentration of 6k. The CS-XTDs systems showed an improved antimicrobial effect with respect to the corresponding XTDs. Good results were obtained for CS-6f, for which the effects on Staphylococcus aureus ATCC 25923 (21.2 ± 0.43 mm) and Sarcina lutea ATCC 9341 (25.1 ± 0.28 mm) were comparable with those of ciprofloxacin (25.1 ± 0.08 mm/25.0 ± 0.1 mm), which were used as the control. The CS-6f showed a notable antifungal effect, especially on Candida parapsilosis ATCC 22019 (18.4 ± 0.42 mm), the effect being comparable to those of nystatin (20.1 ± 0.09 mm), used as the control. Based on the obtained results these polymeric systems, consisting of thiazolidine-4-one derivatives loaded with chitosan microparticles, could have important applications in the food field as multifunctional (antimicrobial, antifungal, antioxidant) packaging materials.

show abstract

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of New Polymeric Systems Based on Chitosan and Xanthine Derivatives with Thiazolidin-4-One Scaffold

et al. 2019

View full text Add to dashboard Cite

show abstract

Activities of Thiazolidine-4-one and Azetidine-2-one Derivatives- A Review

Ramachandran

Cheriyan

Aanandhi

2021

RJPT

View full text Add to dashboard Cite

Thiazolidine-4-ones containing thiazole moiety have been synthesized by condensing 6-amino Coumarin, Isatin and Primary amines, and aromatic aldehydes. Azetidine derivates were synthesized followed by cyclizations by C-N bond formation and by the C-C bond formation, the amine-catalyzed cycloaddition of allenoates and imines, photocycloadditions of imines and alkenes, ring contraction and expansion rearrangements, and reduction of azetidine-2-ones (β-lactams). Thiazolidine-4-ones has been considered as a magic moiety because it posses almost all types of biological activities such as Antifungal, Antitubercular, Antimicrobial, Antioxidant, Antibacterial, Cytotoxic, Anti-inflammatory, Analgesic, Anti YFV (yellow fever virus) activities. Azetidine-2-one derivatives were reported to possess antibacterial, antifungal and antidepressant activity, anticonvulsant activity, anti-inflammatory activity and cardiovascular activities, antimycobacterial activity, antihypertensive activity. This article is a review of various biological activities of thiazolidine-4-ones and Azetidine-2-ones derivatives.

show abstract

Synthesis, Characterisation, Antimicrobial Evaluation of 2-Hydroxy Phenyl Thiazolidine-4-One Derivative

Cited by 2 publications

References 7 publications

Formulation and Characterization of New Polymeric Systems Based on Chitosan and Xanthine Derivatives with Thiazolidin-4-One Scaffold

Formulation and Characterization of New Polymeric Systems Based on Chitosan and Xanthine Derivatives with Thiazolidin-4-One Scaffold

Activities of Thiazolidine-4-one and Azetidine-2-one Derivatives- A Review

Contact Info

Product

Resources

About