15. Potency of Methanolic Extract of Sernai Stems (Wedelia biflora) as Analgesic on Mice (Mus musculus)

Rahmatia, Annisa Rizka; Rinidar, Rinidar; Tr, T. Armansyah; Rosmaidar, Rosmaidar; Harris, Abdul; Fahrimal, Yudha

doi:10.21157/j.med.vet..v12i2.4230

Cited by 2 publications

(2 citation statements)

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“…As an analgesic dose works in 30-90 minutes, Ibuprofen will decrease performance in 120 minutes 16 . Meanwhile, according to Carter, W.C. and B.R.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus)

et al. 2022

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Background:Putri Malu plants (Mimosa pudica linn) contain flavonoid compounds that are useful as hepatoprotectors. Putri Malu plants extract can be usefull to prevent problem such as Ibuprofen-induced hepatic damage., but study that focus on this topic remain scarce in Indonesia. Objective: To prove the extracted content of the leaves of the Putri Malu plant (Mimosa pudica linn) as a hepatoprotector of hepatic damage in mice (Mus musculus) induced by Ibuprofen. Method: This randomized post-test control group design was conducted at the Experimental Animal Laboratory, Faculty of Veterinary Medicine, Universitas Airlangga. A total of 28 mice were treated with four condition then underwent SGOT and SGPT blood laboratory tests. Results: Group P1 (placebo) had SGOT and SGPT levels averaging 23.87 mg/dl and 13.45 mg/dl, group P2 (ibuprofen dose 7 mg/KgBW) had SGOT and SGPT levels of 29.13 mg/dl and 19.10 mg/dl, group 3 (Putri Malu extract 35 mg/KgBW) had SGOT and SGPT of 24.05 mg/dl and 13.56 mg/dl, and group 4 (ibuprofen dose 7 mg/KgBW and Putri Malu extract of 35 mg/KgBW) showed SGOT and SGPT levels of 28.23 mg/dl and 18.35 mg/dl. The four groups had different mean SGOT and SGPT levels (P 0,000). Conclusion:Leaf extract of the Putri Malu plants (Mimosa pudica linn) has a chemical effect of heaptoprotector as shown by the decrease in SGOT and SGPT level.

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“…As an analgesic dose works in 30-90 minutes, Ibuprofen will decrease performance in 120 minutes 16 . Meanwhile, according to Carter, W.C. and B.R.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus)

et al. 2022

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“…Kerusakan jaringan terjadi karena adanya rangsangan mekanik, kimia atau fisik (kalor dan listrik) sehingga dapat menimbulkan rasa nyeri. Timbulnya rasa nyeri berfungsi untuk melindungi serta memberikan tanda bahaya tentang adanya gangguan di dalam tubuh (Rahmatia et al, 2018). Nyeri (dolor) juga merupakan salah satu gejala dari kondisi inflamasi yang terjadi di dalam tubuh.…”

Section: Pendahuluanunclassified

UJI DAYA ANALGETIK DAN ANTIINFLAMASI EKSTRAK ETANOLIK DAUN SINGKONG (Manihot utilissima Pohl.) PADA MENCIT GALUR SWISS

Octasari¹,

Wardani²,

Sari³

2022

wiyata

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Background: Flavonoids are compounds that can function as analgesics and anti-inflammatory. Cassava leaves are known to contain flavonoids with the main content of rutin. The routine flavonoid content in the ethanolic extract of cassava leaves is 4.987% so that it has the potential to be developed as traditional medicine. Objective: This study aimed to determine the analgesic and anti-inflammatory properties of cassava leaf ethanolic extract (EEDS) and the effect of varying doses of EEDS on analgesic and anti-inflammatory properties. Methods: This study was a completely randomized experimental study with a unidirectional pattern in mice aged 2-3 months and weighing 20-30 grams. Analgesic testing method used the stretching method with 1% acetic acid as the induction, while the anti-inflammatory test used the edema thickness measurement method with 1% carrageenin induction. The results of the percentage of protection, the change in the percentage of protection, and the percentage of anti-inflammatory power were statistically analyzed. Results: The results showed that EEDS was green-black in color, bitter in taste, 7% drying loss, 12.31% w/w yield and positive for flavonoids. EEDS has analgesic power at a dose of 70; 140; and 280 (mg/kgBB) with a percentage of protection of 26.59%; 24.45%; and 21.96%; change in percentage of protection by 65.75%; 68.51%; and 71.72%. EEDS at a dose of 35; 70; and 140 (mg/kgBW) has a percentage of anti-inflammatory power of 44.93%; 37.34%; and 30.75%. Conclusion: The higher the dose of EEDS, the higher the analgesic power but the lower the anti-inflammatory power

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15. Potency of Methanolic Extract of Sernai Stems (Wedelia biflora) as Analgesic on Mice (Mus musculus)

Cited by 2 publications

References 0 publications

Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus)

Efficacy of Putri Malu Leaf Plant (Mimosa Pudica Linn) as Hepatoprotectors on Ibuprofen Induced Hepatic Damage in White Mice (Mus Musculus)

UJI DAYA ANALGETIK DAN ANTIINFLAMASI EKSTRAK ETANOLIK DAUN SINGKONG (Manihot utilissima Pohl.) PADA MENCIT GALUR SWISS

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