Identifying potential drug interactions in chronic kidney disease patients

Marquito, Alessandra Batista; Fernandes, Natália; Colugnati, Fernando Antônio Basile; Paula, Rogério Baumgratz de

doi:10.5935/0101-2800.20140006

Cited by 45 publications

(74 citation statements)

References 31 publications

(36 reference statements)

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“…The prevalence of pairs of major severity PDDI was 10.7 % in the present study, this result falling within the values (3.67-17.6 %) present in other investigations with patients receiving outpatient treatment, which included DM2 [19,24,26,27]. The major PDDI are considered clinically relevant, as it is important for health professionals to be aware of the risks related to the PDDI, so that measures may be implemented in order to ensure safe care for the patient.…”

Section: Discussionsupporting

confidence: 87%

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Prevalence and clinical significance of potential drug-drug interactions in diabetic patients attended in a tertiary care outpatient center, Brazil

Trevisan

Silva

Póvoa

et al. 2015

Int J Diabetes Dev Ctries

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The aim of this study is to investigate the prevalence of potential drug-drug interactions (PDDIs), as well as classifying them in relation to level of severity, scientific evidence, time of onset, and potential clinical impact in adult and older adult patients with diabetes mellitus 2 (DM2). This cross-sectional study was conducted in a tertiary care outpatient center. The consecutive sample was made up of 140 patients with DM2. The Anatomical-Therapeutic-Chemical Classification was used for classifying the classes of medications. The PDDIs were analyzed using the DRUG-REAX® system. The relationships between PDDI and the associated factors were ascertained using a multiple logistic regression model. The prevalence of total PDDI was 75 %, and the prevalence of major severity PDDI was 20.7 %. Simvastatin (30.8 %), captopril/enalapril (12.8 %), and oral anti-diabetics/insulin (12.8 %) were the medications which were most involved in the major PDDI, bringing relevant potential clinical impacts such as rhabdomyolysis, hyperkalemia, and important glycemic alterations. Polypharmacy was associated with PDDI (adjusted odds ratio = 10.46, 95 % confidence interval = 4.10-26.71). Diabetics were highly exposed to clinically significant PDDI. It is important that health professionals should be aware of the risks related to PDDI, so that measures may be implemented in order to assure safe care for the patient.

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Section: Discussionsupporting

confidence: 87%

“…The patients in the present investigation used a number of medications (6.3; SD 2.6) similar to that in other studies held in a tertiary healthcare outpatient center which included patients with DM2 in their samples [24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and clinical significance of potential drug-drug interactions in diabetic patients attended in a tertiary care outpatient center, Brazil

Trevisan

Silva

Póvoa

et al. 2015

Int J Diabetes Dev Ctries

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“…Estudo recente com 205 pacientes portadores de DRC apresentou uma frequência de 76,1% potenciais IM, com 2,7 IM por prescrição. 23 Vários outros trabalhos avaliaram a presença de potenciais IM, apresentando prevalências entre 20,3% e 63,0%. 8,9,13,24,[34][35][36] Quando avaliada a relação entre IM e dados demográficos e socioeconômicos, não houve associação significativa, ao contrário de outros trabalhos que demonstraram associação da prevalência de IM com o sexo feminino e com o aumento da idade.…”

Section: Discussionunclassified

“…5 Nos doentes renais crônicos a prevalência de potenciais IM varia de 74,2% entre pacientes em manejo conservador a 78,0% entre pacientes em terapia dialítica. [21][22][23] As IM são muitas vezes previsíveis e, portanto, evitáveis ou controláveis. Apesar dos grandes avanços no entendimento das IM nos últimos anos, as reações causadas são em sua maioria desconhecidas, bem como a capacidade de aplicar adequadamente essas informações na prática clínica, ocasionando impactos negativos sobre a morbidade, a mortalidade, o tempo de hospitalização, a qualidade de vida e os custos em saúde.…”

Section: Introductionunclassified

Avaliação dos medicamentos utilizados e possíveis interações medicamentosas em doentes renais crônicos

Sgnaolin

Engroff

et al. 2014

Sci Med

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“…Because this type of patient requires multiple types of drugs, their kidney and liver may decrease the excretion and metabolize the ability of medications. Therefore, the occurrence of DDIs in this type of patient may be signi cant [5,6,7,11,12].…”

Section: Introductionmentioning

confidence: 98%

Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies

Ayenew

Asmamaw

Issa

2020

Preprint

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Background: Drug-drug interaction is an emerging threat to public health. Currently, there is an increase in comorbid disease, polypharmacy, and hospitalization in Ethiopia. Thus, the possibility of drug-drug interaction occurrence is high in hospitals. This study aims to summarize the prevalence of potential drug-drug interactions and associated factors in Ethiopian hospitals.Methods: A literature search was performed by accessing legitimate databases in PubMed/MEDLINE, Google Scholar, and Research Gate for English-language publications. To fetch further related topics advanced search was also applied in Science Direct and HINARI databases. The search was conducted on August 3 to 25, 2019. All published articles available online until the day of data collection were considered. Outcome measures were analyzed with Open Meta Analyst and CMA version statistical software. Der Simonian and Laird’s random effect model, I2 statistics, and Logit event rate were also performed.Results: A total of 14 studies remained eligible for inclusion in systematic review and meta-analysis. From the included studies, around 8,717 potential drug-drug interactions were found in 3,259 peoples out of 5,761 patients. The prevalence of patients with potential drug-drug interactions in Ethiopian hospitals was found to be 72.2% (95% confidence interval: 59.1%, 85.3%). Based on severity, the prevalence of major, moderate, and minor potential drug-drug interaction was 25.1%, 52.8%, 16.9%, respectively, also 1.27% for contraindications. The factors associated with potential drug-drug interactions were related to patient characteristics such as polypharmacy, age, comorbid disease, and hospital stay.Conclusions: There is a high prevalence of potential drug-drug interactions in Ethiopian hospitals. Polypharmacy, age, comorbid disease, and hospital stay were the risk factors associated with potential drug-drug interactions.

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Identifying potential drug interactions in chronic kidney disease patients

Abstract: Drug associations in individuals with CKD were related to high prevalence of serious DIs, especially in the later stages of the disease.

Cited by 45 publications

References 31 publications

Prevalence and clinical significance of potential drug-drug interactions in diabetic patients attended in a tertiary care outpatient center, Brazil

Prevalence and clinical significance of potential drug-drug interactions in diabetic patients attended in a tertiary care outpatient center, Brazil

Avaliação dos medicamentos utilizados e possíveis interações medicamentosas em doentes renais crônicos

Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies

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