2015
DOI: 10.1007/s13410-015-0428-7
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Prevalence and clinical significance of potential drug-drug interactions in diabetic patients attended in a tertiary care outpatient center, Brazil

Abstract: The aim of this study is to investigate the prevalence of potential drug-drug interactions (PDDIs), as well as classifying them in relation to level of severity, scientific evidence, time of onset, and potential clinical impact in adult and older adult patients with diabetes mellitus 2 (DM2). This cross-sectional study was conducted in a tertiary care outpatient center. The consecutive sample was made up of 140 patients with DM2. The Anatomical-Therapeutic-Chemical Classification was used for classifying the c… Show more

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Cited by 3 publications
(3 citation statements)
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“…Estudo transversal que utilizou banco de dados de pesquisa prévia 6 que avaliou a prevalência de IMp em pacientes com DCNT. Seguiu-se recomendações da Declaração STROBE na elaboração 17 .…”
Section: Desenho Do Estudounclassified
See 1 more Smart Citation
“…Estudo transversal que utilizou banco de dados de pesquisa prévia 6 que avaliou a prevalência de IMp em pacientes com DCNT. Seguiu-se recomendações da Declaração STROBE na elaboração 17 .…”
Section: Desenho Do Estudounclassified
“…As IMp indesejáveis podem acarretar diminuição da eficácia (com consequente fracasso terapêutico) ou aumento de toxicidade 1,2 . A identificação deste fenômeno, sobretudo daquelas de maior relevância clínica (por exemplo, de gravidades "Contraindicada" e "Maior"), bem como o seu monitoramento em conjunto com julgamento clínico podem prevenir e reduzir eventos adversos [4][5][6] .…”
Section: Introductionunclassified
“…A Brazil study comprised 140 diabetes patients who attended a tertiary care outpatient center, indicated a prevalence of 75% of potential drug–drug interactions, of which 20.7% were major interactions. 7 And a study from Croatia identified that 80.9% of diabetes patients had at least one potential drug interaction requiring monitoring of therapy. 8 Most of the antidiabetic drug interactions may result in hypoglycemia-related complications.…”
Section: Introductionmentioning
confidence: 99%