Drug-drug interaction

Bastos, Marcus Gomes

doi:10.5935/0101-2800.20140003

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…The highest occurring co-morbidity was hypertension and patients with hypertension as a co-morbid state had higher risk of drug-drug interactions. Anti-hypertensives have been indicated with a high number of DDIs [ 10 , 13 ]. In a study among renal failure patients of the nephrology ward in a South Indian tertiary care hospital, calcium channel blockers and beta blockers constituted the major class of drugs involved in interactions [ 9 ].…”

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confidence: 99%

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Evaluation of drug-drug interactions among patients with chronic kidney disease in a South-Eastern Nigeria tertiary hospital: a retrospective study

2017

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IntroductionThe risk of drug-drug interactions (DDIs) is high in patients with chronic kidney disease (CKD) necessitating dose adjustments or the avoidance of drug combinations. This study aimed to evaluate DDIs among patients with CKD in the University of Nigeria Teaching Hospital (UNTH), Enugu, South-East Nigeria.MethodsThis study was a retrospective review of patients with CKD who received treatment at the nephrology unit of UNTH between January 2004 and December 2014. The drug-drug interactions (DDIs) of the prescribed drugs were classified using the RxList interaction checker. The IBM SPSS Version 21.0 was utilized for statistical analysis with P-value ≤ 0.05, considered statistically significant.ResultsA total of 749 DDIs were identified from the folders of the 169 patients with CKD that were eligible. Majority were above 50 years old and in stage 4 or 5 CKD. Furosemide, lisinopril and amlodipine were the most frequently prescribed drugs and had the greatest likelihood for nephrotoxicity. The number of medications and hypertension (as co-morbidity) were significant and independent predictors of DDIs among the patients. About 70% of the drug combinations required monitoring as they fell within the “significant category” of the RxList interaction checker. The most common interactions were between lisinopril and furosemide; furosemide and calcium carbonate; lisinopril and calcium carbonate.ConclusionThe prevalence of DDIs was high among the CKD patients. Prescribers and pharmacists in Nigerian hospitals may need to pay close attention to prescriptions of patients with CKD to identify, prevent and resolve undesirable DDIs.

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Section: Discussionmentioning

confidence: 99%

“…Individuals with CKD are at high risk for drug interactions as they often require different classes of drugs [ 8 , 9 ]. Drug interactions may increase morbidity, lead to hospitalizations and deaths [ 10 ]. A useful drug interaction tool is the Rx List drug interaction checker.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of drug-drug interactions among patients with chronic kidney disease in a South-Eastern Nigeria tertiary hospital: a retrospective study

2017

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CBIRS/TB Using Color Feature Information for A tablet Recognition

Seo¹

2014

Journal of the Korea Society of Computer and Information

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This thesis proposes CBIRS/TB method that uses a tablet's color distribution information and form distinctive in content-based search. CBIRS/TB can avoid misuses and improper tablet uses by conducting content-based search in commonly prescribed tablets. The existing FE-CBIRS system is limited to recognizing only the image of color and shape of the tablet, that leads to applying insufficient form-specific information. While CBIRS/TB utilizes average, standard deviation, hue and saturation of each tablets in color, brightness, and contrast, FE-CBIRS has partial-sphere application problem; only applying the typical color of the tablet. Also, in case of the

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Drug-drug interaction

Cited by 2 publications

References 9 publications

Evaluation of drug-drug interactions among patients with chronic kidney disease in a South-Eastern Nigeria tertiary hospital: a retrospective study

Evaluation of drug-drug interactions among patients with chronic kidney disease in a South-Eastern Nigeria tertiary hospital: a retrospective study

CBIRS/TB Using Color Feature Information for A tablet Recognition

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