No abstract

No abstract

IntroductionThe risk of drug-drug interactions (DDIs) is high in patients with chronic kidney disease (CKD) necessitating dose adjustments or the avoidance of drug combinations. This study aimed to evaluate DDIs among patients with CKD in the University of Nigeria Teaching Hospital (UNTH), Enugu, South-East Nigeria.MethodsThis study was a retrospective review of patients with CKD who received treatment at the nephrology unit of UNTH between January 2004 and December 2014. The drug-drug interactions (DDIs) of the prescribed drugs were classified using the RxList interaction checker. The IBM SPSS Version 21.0 was utilized for statistical analysis with P-value ≤ 0.05, considered statistically significant.ResultsA total of 749 DDIs were identified from the folders of the 169 patients with CKD that were eligible. Majority were above 50 years old and in stage 4 or 5 CKD. Furosemide, lisinopril and amlodipine were the most frequently prescribed drugs and had the greatest likelihood for nephrotoxicity. The number of medications and hypertension (as co-morbidity) were significant and independent predictors of DDIs among the patients. About 70% of the drug combinations required monitoring as they fell within the “significant category” of the RxList interaction checker. The most common interactions were between lisinopril and furosemide; furosemide and calcium carbonate; lisinopril and calcium carbonate.ConclusionThe prevalence of DDIs was high among the CKD patients. Prescribers and pharmacists in Nigerian hospitals may need to pay close attention to prescriptions of patients with CKD to identify, prevent and resolve undesirable DDIs.

BACKGROUND: Stigma affects the quality of life of the mentallyill, and health professionals are considered to be involved in possessing negative attitudes towards them. We evaluated the  prevalence of stigmatization among different health professionals in Nigerian hospitals.METHODS: This study was a descriptive, cross-sectional and comparative survey assessing attitudinal views of health professionals (doctors, pharmacists, and nurses) regarding mental illness in two hospitals in Eastern Nigeria. The survey utilized the 40-item Community Attitude to Mental Illness, CAMI-2 questionnaire. The prevalence and the factors that contribute to negative attitudes among this cohort were assessed. Statistical analysis using T-tests, ANOVA and Pearson Correlation were conducted.RESULTS: Attitudes to all the four constructs of the CAMI-2 werenon-stigmatizing. Stigmatizing attitudes were significantly higheramong pharmacists, doctors and then nurses (p<0.006). Health professionals who did not have contact with the mentally ill (p<0.0001), who were males (p=0.008) and had lower years of working experience (p=0.031) expressed significantly higher stigmatizing attitudes towards the mentally ill.Conclusions: Nigerian health professionals were largely non-stigmatizingtowards the mentally ill. However, being a pharmacist, of male gender, and working in a non-psychiatric hospital were associated with stigmatizing attitudes when they exist.KEYWORDS: Mental illness; Stigma; Health Professionals;Survey

Rationale:The pharmacist charged with the responsibility of drug administration and counseling should have the basic knowledge and skills necessary to demonstrate the use of metered dose inhalers (MDIs) to asthma patients for the maximization of treatment outcomes.Objective:This study was designed to evaluate the community pharmacists’ knowledge of the appropriate use of MDIs in Anambra State, Nigeria.Methods:The study was carried out in two major cities in Anambra State, Nigeria, using 41 registered community pharmacists. A simulated patient approach utilizing two adequately trained pharmacy students were used. Obtained data were analyzed using independent t-test and one-way ANOVA through SPSS version 18.Results:The pharmacists had a mean demonstration score of 45.45%. Step number seven of the correct use of MDI, which involves breathing in and depressing the canister was the most demonstrated step (90.2%) while step 4 which involves tilting the head back slightly was the least demonstrated (14.6%) by the pharmacists. Among five identified critical steps in asthma guideline used, two were well demonstrated (75.6% and 90.2%): one averagely demonstrated (51.2%) and two poorly demonstrated (39% and 31.7%). Sociodemographic characteristics did not influence the demonstration ability of the pharmacists in this study.Conclusion:The study indicated that community pharmacists lacked the adequate knowledge of appropriate use of MDI. Training programs for pharmacists focusing on the use of such devices will enable them to educate patients on the effective use of MDIs in patients with asthma.

Background: The increasing migration of health workers from low- and middle-income countries is an ongoing public health concern. This study evaluated the brain drain potential of pharmacy students in Nigeria.  Methods: This was a cross-sectional survey of final year pharmacy students from three Nigerian universities. Data collection was done via a 46-item self-administered questionnaire.     Results: There were 377 respondents. Reasons for potential emigration included better standard of living (n=334, 88.6%), access to advanced technology (n=330, 87.5%) and opportunity for professional development (n=341, 90.5%) in the destination countries. Respondents younger than 25 years were more likely to have a high emigration potential compared to those older (98.6% vs 84.6%, ꭓ2=10.816, p=0.029).     Conclusion: This study showed high emigration potential for the surveyed final year pharmacy students. This highlights the need for interventions that will promote retention and limit brain drain.

Sachet water is a form of packaged water commonly sold in West Africa [1]. It refers to water of approximately 500 ml volume that is purified, packaged and sold for drinking in heat-sealed plastic sleeves ('sachets'). Nationally representative surveys show that up to 18% of urban households in Nigeria depend on sachet water for drinking, cooking and other domestic uses with only a small fraction utilising bottled water products [2]. The year-on-year increase in sachet water consumption observed in West Africa is driven in part by consumer purchasing behaviour, relative affordability, inadequate water supply infrastructure due to increasing urbanisation and limited access to safe and sustainable

Objectives Medication adherence is still a significant problem in chronic diseases management and rheumatoid arthritis (RA) is not an exception. There is very little information regarding the level and influencing factors of medication adherence among Nigerian patients with RA. This study evaluated the level and determinants of medication adherence among patients with RA in a Nigerian referral hospital. Methods Using a questionnaire based cross sectional survey, 169 patients with RA were evaluated for their medication adherence using two validated instruments namely; five-item Medication Adherence Report Scale and five-item Compliance Questionnaire for Rheumatology. The two instruments were subjected to descriptive (mean and frequencies) and mean difference (chi-square, t-test, Pearson correlation) analysis, and their reliability (Cronbach alpha) in a Nigerian setting was also established. Key findings The level of non-adherence reported in this study was high and ranged from 48.5% for the CQR to 63.9% for the Medication Adherence Report Scale questionnaires respectively. Being of a male gender, of an older age, the higher number of pills taken, better education and the duration of the disease all significantly contributed to higher adherence measures among these RA patients (P &lt;0.05 for all). Both questionnaires used were correlated and reliable for use among patients with rheumatoid arthritis in Nigeria. Conclusion Findings from this study show that non adherence to medications among RA patients were high and factors such age, gender, education, pill burden could have been responsible.