2009
DOI: 10.4322/rbpv.01801002
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Abstract: ResumoNeospora caninum é um dos principais agentes causadores de abortamentos e natimortalidade em bovinos. A defesa imune do hospedeiro é capaz de inibir a atividade dos taquizoítos na fase aguda da infecção, mas não age sobre os bradizoítos nos cistos teciduais. A ativação e a modulação dessa resposta de defesa são controladas por mediadores celulares. A técnica do RT-PCR em tempo real foi empregada para a detecção de alguns desses mediadores durante a infecção pelo N. caninum. Foram analisadas amostras de l… Show more

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Cited by 7 publications
(3 citation statements)
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“…The balance between the tachyzoite's ability to penetrate and multiply into host cells and the host's ability to inhibit parasite multiplication was discussed by Buxton et al (2002) adult cattle suggests that the immune system responds efficiently to N. caninum through humoral immune response mediated by secreted antibodies, and by cellular immune response mediated by Th1 and Th2 (YAMANE et al, 2000;INNES et al, 2005;PINHEIRO et al, 2006;NISHI et al, 2009). …”
Section: Results Discussion and Conclusionmentioning
confidence: 99%
“…The balance between the tachyzoite's ability to penetrate and multiply into host cells and the host's ability to inhibit parasite multiplication was discussed by Buxton et al (2002) adult cattle suggests that the immune system responds efficiently to N. caninum through humoral immune response mediated by secreted antibodies, and by cellular immune response mediated by Th1 and Th2 (YAMANE et al, 2000;INNES et al, 2005;PINHEIRO et al, 2006;NISHI et al, 2009). …”
Section: Results Discussion and Conclusionmentioning
confidence: 99%
“…The production of interleukin 12 (IL-12) by antigen-presenting cells stimulates natural killer cells that lyse infected cells [13,16]. N. caninum infection triggers a cellular response mediated by proinflammatory cytokines such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and the induction of inducible nitric oxide synthase (iNOS) associated with phagocytic activity [17]. The proteins present on the outer surface of Leptospira sp.…”
Section: Introductionmentioning
confidence: 99%
“…O desempenho satisfatório da técnica depende, entre outros fatores, da escolha dos oligonucleotídeos e da técnica utilizada de extração do ácido nucléico da amostra (COLLINS et al, 1994). A PCR em tempo real (qPCR) é uma metodologia rápida, mais adequada para análise de grande número de amostras e pode quantificar a concentração de ácido nucléico (CAI et al, 2005), o que resulta em maior sensibilidade (NISHI et al, 2009 .…”
Section: Capítulo -Introduçãounclassified