Genomic Association between SNP Markers and Diseases in the “Curraleiro Pé-Duro” Cattle

Freitas, Thais Miranda Silva; Dias, Juliana Moraes; Guimarães, Luanna Elis; Peixoto, Sáudio Vieira; Silva, Rayanne Henrique Santana da; Badr, Kareem Rady; Moura, Maria Ivete de; Carmo, Adriana Santana do; Landi, Vincenzo; Fíoravantí, Maria Clorínda Soares

doi:10.3390/genes12060806

Genes

2021

DOI: 10.3390/genes12060806

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Genomic Association between SNP Markers and Diseases in the “Curraleiro Pé-Duro” Cattle

Thais Miranda Silva Freitas

Juliana Moraes Dias

Luanna Elis Guimarães

et al.

Abstract: Susceptibility to diseases is inherited and can be transmitted between populations. Single-nucleotide polymorphism (SNPs) in genes related to immune response is associated with diseases in cattle. This study investigated SNPs in the genomic region of cytokines in 702 samples of Curraleiro Pé-Duro cattle and associated them with the occurrence of antibodies in brucellosis, leptospirosis, neosporosis, leukosis, infectious bovine rhinotracheitis (IBR), and bovine viral diarrhea (BVD) tests. DNA samples were evalu… Show more

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Cited by 3 publications

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“…Freitas et al (2021) also conducted a traditional candidate gene analysis in a local Brazilian breed (Curraleiro Pé-Duro). Thirteen candidate genes of immune response Significant comparisons between breeds within experiments are in bold.…”

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The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle

Dinon,

Fiorani,

Campero

et al. 2024

Animal Genetics

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Neospora caninum is one of the most frequently diagnosed abortifacient pathogens in cattle. There is abundant genomic information about the parasite itself, but very little is known about the genetic variability of resistance in the most common intermediate host. The aim of this review was to compile all the available information about the genetic variability associated with the resistance to N. caninum both between and within cattle breeds. We systematically searched for published studies that investigated the influence of genetics of the host on the prevalence of N. caninum and risk of abortion. Beyond the potential confounding effects of feeding systems, management and animal density, some lines of evidence suggest that Holstein, the most popular breed for milk production, has a comparatively higher risk of abortion due to infections by N. caninum, whereas some beef breeds from Continental Europe seem to be more resistant. It is still not clear if different genetic mechanisms of resistance are involved in the two known routes of infection: postnatal ingestion of oocysts or transplacental transmission from the infected dam to the fetus. Genomic information associated with susceptibility to infection and risk of abortion in different cattle breeds is still scarce. The information reported here could be useful to identify new research alternatives and to define novel strategies to deal with this major problem of animal production.

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confidence: 99%

The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle

Dinon,

Fiorani,

Campero

et al. 2024

Animal Genetics

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First record of a possible trypanotolerant cattle breed in Latin America: Parasitological, serological, and clinical aspects

de Mendonça,

Couto,

Pureza

et al. 2024

Veterinary Parasitology: Regional Studies and Reports

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The first Brazilian bovine breed: structure and genetic diversity of the Curraleiro Pé-duro

Silva

Sarmento

Britto

et al. 2023

PeerJ

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Background The production of animal-based foods from native breeds have a synergistic relationship with the regional culture, the local climate, and mainly the maintenance of alternative genetic resources for a system with a lower environmental impact. Thus the efficiency of conservation and production depends on assessing the variability of these local breeds. In the case of Curraleiro Pé-duro cattle, the most adapted individuals have undergone natural selection over five hundred years in the Brazilian savannas, mating with little or no human interference. The peculiarities of these biomes, where the regional flora is the food base and cattle is raised in extensive areas, likely influenced the genetic composition of the different groups that make up the first cattle breed of Brazil. Methods To evaluate the composition, diversity, variation, differentiation, and genetic structure of the populations studied, samples of hair follicles from 474 individuals of different animal categories (calves, yearlings, heifers, cows, and bulls) from three farms, defined as subpopulations “A”, “B”, and “C”, were collected. The animals were genotyped for 17 microsatellite markers using a DNA sequencer. After verification of monomorphic alleles, alleles outside the expected size range, and for the presence of stutter bands, the results were subjected to statistical analysis. Results The markers used were suitable for the proposed application with a mean Polymorphism Information Content (PIC) of 0.62. On average, the effective alleles were 4.25 per marker, with mean heterozygosities of 0.74 (observed and expected), which was lower in herd A (0.70) in comparison to herds B (0.77) and C (0.74). The analysis of molecular variance (AMOVA) revealed a higher rate of variation within herds (98.5%) and lower among herds (1.5%) (FSTranging from 0.00723 and 0.03198; p-values < 0.05). However no significant differences among herds where found with the Mantel test based on geographic distances. The formation of genetic clusters of all animals sampled with the software Structure resulted in minimum cluster values, with two main genetic groups (K = 2) observed among the evaluated animals. Therefore, based on PIC and heterozygosity values, a wide genetic diversity was observed, despite little differences in population structure (AMOVA, FST, and Structure results) among sampling sites.

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Genomic Association between SNP Markers and Diseases in the “Curraleiro Pé-Duro” Cattle

Cited by 3 publications

References 42 publications

The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle

The role of genetic variability of the host on the resistance to Neospora caninum infection in cattle

First record of a possible trypanotolerant cattle breed in Latin America: Parasitological, serological, and clinical aspects

The first Brazilian bovine breed: structure and genetic diversity of the Curraleiro Pé-duro

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