Development of a second type electrode based on the silver/silver ibuprofenate pair for ibuprofen quantification in pharmaceutical samples

Abstract

Ibuprofen is a widely used pharmaceutical because of its therapeutic properties; it is considered a safe medicament, thus it does not require medical prescription to be sold. However, in order to ensure consumer's health it is indispensable that the pharmaceutical industry relies on analytic methods for its quantification. Potentiometry has proven to be a successful technique using second type electrodes, which in agreement with Nernst's equation can detect anions activity. On consideration of this, this research work presents the development of a second type electrode based on the silver/silver ibuprofenate pair. This involved modifying a pure silver wire using a sodium ibuprofenate solution, to obtain the redox pair. The following analytic parameters were obtained with the aid of the modified electrode: a sensitivity of -0.049 V decade [ibuprofenate] −1 , 8 µmol L -1 for the detection limit and a quantification limit of 1.2 µmol L -1 . The repeatability value in terms of the relative standard deviation was 5.9%. After performing an interferences analysis using some ions and excipients, it was corroborated that there were none, thus allowing appropriate quantification on a real sample.

Determination of Ibuprofen in Tablets and Human Blood Samples: Effect of Clay in Minimizing Overvoltage of Ibuprofen Oxidation

“…By comparing the performance characteristics of the Clay−CPE with other electrodes (Table ), it is clear that our modified electrode is far better regarding the ibuprofen determination with precision. The limit of detection and sensitivity are comparable to those of others electrodes . The reproducibility of clay‐CPE was also investigated in 1.0 × 10 −5 mol L −1 of ibuprofen and the relative standard deviation (RSD) was 2.31% for eight successive measurements.…”

Quantitative Determination of Some Non-Steroidal Anti-Inflammatory Drugsand Their Acid Dissociation Constants by Direct Potentiometry

“…Santini et al, proposed a simple second type electrode for ibuprofen analysis, based on the Hg/HgIbu pair with very good results [29]. Another paper has presented the development of a new second-type electrode proposal, based on the pair silver/silver ibuprofenate, (Ag/AgIbu), which in agreement with the Nernst equation, allows the quantification of ibuprofenate ions [30]. Potentiometric methods based on ion-selective electrodes [31] proposed by various scientists, require strict pH control for accurate and precise results.…”