Quantitative Determination of Some Non-Steroidal Anti-Inflammatory Drugsand Their Acid Dissociation Constants by Direct Potentiometry
VANIA MASLARSKA
Abstract:Objective: A potentiometric titration method was applied to determine non-steroidal anti-inflammatory drugs. The quantitative analysis and the treatment of the primary data are based on a nonlinear regression procedure using commercial software. A general formula valid for every type of acid-base titration, derived before is used as a direct input.
Methods: Potentiometric titration of ibuprofen, flurbiprofen, and ketoprofen with sodium hydroxide solution (0.1 mol/l). The solutions of ibuprofen, flurbiprofen, a… Show more
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