In the current research, clay particles modified graphite electrode (Clay−CPE) was used for the electrocatalytic oxidation of ibuprofen (IBU). This clay was utilized to reduce the distortions of ibuprofen oxidation peak shape and for a better signal to noise ratio. The surface characterization of the clay and their activity toward IBU oxidation were studied by electrochemical methods in particular: cyclic voltammetry, Tafel plots and electrochemical impedance spectroscopy. The number of the electrons, rate constant and kinetic parameters related to ibuprofen oxidation were calculated. The ibuprofen peak gets more symmetrical in the presence of clay giving a detection limit (LOD) of 8.35×10−7 mol L−1 (3Sb/M) using differential pulse voltammetry. The main practical applicability of the modified electrode was explored by determining ibuprofen in tablets and human blood samples.
The present document reports on the electrocatalytic activity of heavy metals (Copper(II), Nickel(II), Manganese(II) and Lead(II)) modified carbon paste electrodes (HM/CPE) for the paracetamol (Pr) oxidation where its results are compared with carbon paste electrode. The voltammetric behavior of Pr is explored where a sensitive anodic peak has appeared at about 0.27 V (vs. Ag/AgCl/3 M KCl) in 0.1 M Na2SO4 (pH 12). This peak results from the irreversible oxidation of Pr at HM/CPE surface. The catalytic effect was evaluated using cyclic and square wave voltammetry. Electrochemical impedance spectroscopy also confirms our experimental results as the HM/CPE shows the least charge transfer resistance. Also, HM/ CPE can be utilized successfully to ameliorate the electroanalysis of Pr at very weak concentration with excellent sensitivity. The calibration curves were linear from 6.0 · 10-5 to 8.0 · 10-4 mol L-1. The detection limits were found approaching 10-9 mol L-1. Then, the proposed method was applied to detect Pr in river water samples with satisfactory results.
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