The Effect of Continuous Ventilation on Thiol-Disulphide Homeostasis and Albumin- Adjusted Ischemia-Modified Albumin During Cardiopulmonary Bypass

Abstract

Objective To investigate the effect of continuous lung ventilation with low tidal volume on oxidation parameters, such as thiol/disulphide homeostasis and albumin-adjusted ischemia-modified albumin (AAIMA), during cardiopulmonary bypass (CBP) in coronary artery bypass grafting (CABG). Methods Seventy-four patients who underwent elective CABG with CPB were included in the study. Blood samples were taken in the preoperative period, 10 minutes after CPB, and six and 24 hours postoperatively. Patients were assigned to the continuous ventilation group (Group 1, n=37) and the non-ventilated group (Group 2, n=37). The clinical characteristics, thiol/disulphide homeostasis, ischemia-modified albumin (IMA), and AAIMA levels of the patients were compared. Results A significant difference was found between the groups regarding native thiol, total thiol, and IMA levels at the postoperative 24 th hour ( P =0.030, P =0.031, and P =0.004, respectively). There was no difference between the groups in terms of AAIMA. AAIMA levels returned to preoperative levels in Groups 1 and 2, at the 6 th and 24 th postoperative hours, respectively. Length of hospital stay was significantly shorter in Group 1 ( P <0.001) than in Group 2. Conclusion Continuous ventilation during CPB caused an increase in native and total thiol levels, an earlier return of AAIMA levels, and shorter hospital stay. Continuous ventilation may reduce the negative effects of CPB on myocardium (Table 2, Figure 1, and Reference 31).

Effect of mechanical ventilation during cardiopulmonary bypass on oxidative stress: a randomized clinical trial

“…In a study in which a continuous mechanical ventilator strategy was used, the thiol and native thiol levels were significantly higher at 24 hours postoperatively than those of patients who were not ventilated. 29 In the present study, NT increased significantly in Groups 1, 2, and 3 in the postoperative period compared to the intraoperative period. However, only in Group 2, both NT and TT increased in the postoperative period compared to the preoperative and intraoperative periods.…”

Assessment of thiol disulfide balance in early‐stage endometrial cancer

“…9 The relationship of thiol disulfide balance to various disorders and conditions such as cardiopulmonary diseases, diabetes, myomas, labor, molar pregnancies, hypercholesterolemia and idiopathic recurrent pregnancy loss has rarely been evaluated. [10][11][12][13][14][15][16] Although thiol disulfide balance has been investigated in certain types of cancer such as breast, prostate, colon and basal cell cancer, the possible mechanism through which it may be related to carcinogenesis has not been determined. [17][18][19][20] Although various oxidative stress parameters have been studied in patients with endometrial cancer, 21 dynamic thiol disulfide balance has not previously been studied in such patients.…”

“…Using this method, thiol disulfide parameters can be measured practically and precisely 9 . The relationship of thiol disulfide balance to various disorders and conditions such as cardiopulmonary diseases, diabetes, myomas, labor, molar pregnancies, hypercholesterolemia and idiopathic recurrent pregnancy loss has rarely been evaluated 10–16 . Although thiol disulfide balance has been investigated in certain types of cancer such as breast, prostate, colon and basal cell cancer, the possible mechanism through which it may be related to carcinogenesis has not been determined 17–20 …”

The Role of Thiol-Disulfide Hemostasis in Predicting Renal İnjury After Coronary Artery Bypass Graft Surgery

“…In another study conducted by Ozgunay SE et al (13), in cardiac surgery operations using the CPB system, they divided patients in to two groups as those who were continuously ventilated and those who were not ventilated during CPB. In this study, it has been shown that thiol-disulfide hemostasis may be an indicator of increased oxidative stress.…”