Effect of mechanical ventilation during cardiopulmonary bypass on oxidative stress: a randomized clinical trial

Orak, Yavuz; Baylan, Filiz Alkan; Kocaslan, Aydemir; Eroğlu, Erdinç; Acipayam, Mehmet; Kirişçi, Mehmet; Boran, Ömer Faruk; Doğaner, Adem

doi:10.1016/j.bjane.2021.06.024

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Levels of GPX were elevated postoperatively, but without a statistical difference. In the literature, MDA serum levels were significantly increased postoperatively in patients after cardiothoracic, orthopedic, and ophthalmologic surgery [38][39][40][41]. Similar to our results, Kärkkäinen et al [8] found that SOD plasma concentrations significantly increased in the first 24 h after abdominal operations involving laparotomy.…”

Section: Discussionsupporting

confidence: 91%

Oxidative Stress and Inflammation Biomarkers in Postoperative Pain Modulation in Surgically Treated Patients with Laryngeal Cancer—Pilot Study

Vujović

Živković

Dožić

et al. 2023

Cells

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(1) Background: Surgical treatment of laryngeal carcinoma includes different types of laryngectomies with neck dissection. Surgical tissue damage triggers an inflammatory response, leading to the release of pro-inflammatory molecules. This increases reactive oxygen species production and decreases antioxidant defense mechanisms, leading to postoperative oxidative stress. The aim of this study was to assess the correlation between oxidative stress (malondialdehyde, MDA; glutathione peroxidase, GPX; superoxide dismutase, SOD) and inflammation (interleukin 1, IL-1; interleukin-6, IL-6; C–reactive protein, CRP) parameters and postoperative pain management in patients surgically treated with laryngeal cancer. (2) Methods: This prospective study included 28 patients with surgically treated laryngeal cancer. Blood samples were taken for the analysis of oxidative stress and inflammation parameters before the operative treatment and after the operative treatment (1st postoperative day and 7th postoperative day). The concentrations of MDA, SOD, GPX, IL-1, IL-6, and CRP in the serum were determined by coated enzyme-linked immunosorbent assay (ELISA). The visual analog scale (VAS) was used for pain assessment. (3) Results and conclusion: There was a correlation between oxidative stress and inflammation biomarkers and postoperative pain modulation in surgically treated patients with laryngeal cancer. Age, more extensive surgery, CRP values, and use of tramadol were predictors for oxidative stress parameters.

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Section: Discussionsupporting

confidence: 91%

Oxidative Stress and Inflammation Biomarkers in Postoperative Pain Modulation in Surgically Treated Patients with Laryngeal Cancer—Pilot Study

Vujović

Živković

Dožić

et al. 2023

Cells

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show abstract

“…Pulmonary ischemia-reperfusion injury is characterized by endothelial dysfunction, capillary leakage and inflammation, and the damage of pulmonary capillary endothelial cells is the characteristic change of pulmonary ischemia-reperfusion injury [ 2 ]. It is common practice to cease ventilation during CPB since the pulmonary function is performed by an external gas exchanger [ 3 ]. However, terminating the ventilation during CPB will lead to atelectasis, decreased production of surfactants and increased secretion, all of which will merely aggravate any pulmonary complications [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of static lung expansion on pulmonary function following cardiopulmonary bypass in children

Huang,

Lu,

Wang

et al. 2024

Heliyon

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Effect of mechanical ventilation during cardiopulmonary bypass on oxidative stress: a randomized clinical trial

Cited by 2 publications

References 24 publications

Oxidative Stress and Inflammation Biomarkers in Postoperative Pain Modulation in Surgically Treated Patients with Laryngeal Cancer—Pilot Study

Oxidative Stress and Inflammation Biomarkers in Postoperative Pain Modulation in Surgically Treated Patients with Laryngeal Cancer—Pilot Study

Effect of static lung expansion on pulmonary function following cardiopulmonary bypass in children

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