The examination of the nephroprotective effect of montelukast sodium and N-acetylcysteine ın renal ıschemia with dimercaptosuccinic acid imaging in a placebo-controlled rat model

Abstract

Purpose To determine the nephroprotective effect of NAC and Montelukast Sodium administration against the development of renal damage associated with long warm renal ischemia. Methods Twenty-seven rats were randomly divided into 3 study groups, which received NAC, montelukast and placebo, and 3 rats were included in the sham-treated control group. Medications were given 3 days before the procedure. DMSA renal scintigraphy was performed before and after surgery. The right renal pedicle was occluded for 45 min to induce ischemia and then subjected to reperfusion for 6 h (I/R groups). Results On pathological examination, the mean pathological scores of the montelukast and NAC groups were significantly lower than those of the placebo group. (p <0.05). In biochemical examination, significant differences were found in all parameter levels between the placebo group and the montelukast and NAC groups. (p <0.05) When postoperative DMSA renal scintigraphy measurements and renal function levels were compared, significant differences were found between the montelukast and NAC groups and the placebo and sham groups. Conclusion The administration of NAC and montelukast sodium was seen to have a nephroprotective effect against the development of renal damage associated with warm renal ischemia.

The renoprotective potential of montelukast: a scoping review

“…By examining studies about montelukast effects on kidney damage caused by ischemia and reperfusion in rats 26 , 50 , results showed montelukast having nephroprotective effects on kidney tissue and improving microscopic damage caused by ischemia by inhibiting neutrophil infiltration and regulating inflammatory and oxidative mediators.…”

A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation

“…Moreover, a recent study demonstrated that the administration of NAC protected Wistar rats with a kidney injury against long warm renal ischemia. In particular, NAC administration resulted in an improvement in biochemical parameters and renal function when compared to the placebo group [ 97 ].…”

Effects of Itxasol© Components on Gene Expression in Bacteria Related to Infections of the Urinary Tract and to the Inflammation Process

“…Although its exact mechanism is not known, NAC is capable of destroying biofilms formed by bacteria and fungi. In addition, its role as a renal protector has been demonstrated in a study in a model of renal ischemia in rats, where its administration produced an improvement in the renal biochemical parameters of rats treated with NAC after ischemia establishment [ 51 , 52 ].…”