Effects of Itxasol© Components on Gene Expression in Bacteria Related to Infections of the Urinary Tract and to the Inflammation Process

Abstract

Urinary tract infections (UTIs) represent a health problem of the first magnitude since they affect large segments of the population, cause increased mortality and comorbidity, and have a high incidence of relapse. Therefore, UTIs cause a major socioeconomic concern. Current antibiotic treatments have various limitations such as the appearance of resistance to antibiotics, nephrotoxicity, and side effects such as gastrointestinal problems including microbiota alterations that contribute to increasing antibiotic resistance. In this context, Itxasol© has emerged, approved as an adjuvant for the treatment of UTIs. Designed with biomimetic principles, it is composed of arbutin, umbelliferon, and N-acetyl cysteine. In this work, we review the activities of these three compounds concerning the changes they produce in the expression of bacterial genes and those related to inflammation as well as assess how they are capable of affecting the DNA of bacteria and fungi.

N-acetylcysteine Ameliorates Vancomycin-induced Nephrotoxicity by Inhibiting Oxidative Stress and Apoptosis in the in vivo and in vitro Models

“…NAC has strong antioxidant potential as a powerful treatment agent, attenuating oxidative stress-induced cell injury and other pathological events, and is most frequently used in clinical and experimental research despite its classic use as a mucoactive agent 30 . Cela et al have summarized the nephroprotective effects of NAC in their work and pointed out that NAC could be used as an adjuvant treatment ingredient in urinary tract infections to reduce antibiotic drugs nephrotoxic adverse reactions 31 , 32 . These results provided more support that NAC has great clinical value as a renal protective agent of vancomycin.…”

New Light on Plants and Their Chemical Compounds Used in Polish Folk Medicine to Treat Urinary Diseases

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