A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation

Cela-López, José M; Roldán, C.; Gómez-Lizarraga, Gorka; Martı́nez, Vicente

doi:10.3390/molecules26154564

Cited by 6 publications

(7 citation statements)

References 119 publications

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“…The present review covers plants with recognized anti-uropathogenic activities and promising medicinal plants that can treat infection recurrence but are less studied [39,40].…”

Section: Management Of Recurrent Uti By Non-antibiotic Plant-based Pr...mentioning

confidence: 99%

“…Ursolic acid inhibits E. coli biofilm formation, and quinic acid is responsible for the excretion of hippuric acid and acidifies the urine. In contrast, sialic acid has an anti-inflammatory and painkilling effect, but other cranberry components have a complementary or synergistic role that contributes to the antibacterial development [1,40].…”

Section: Vaccinium Macrocarpon-cranberrymentioning

confidence: 99%

“…Recent reviews analyzed the data obtained during clinical trials that have been conducted to assess the efficiency of cranberry extracts/juice/syrup/tablets/capsules in UTI treatment. They concluded that they are mixed results and more significant welldesigned trials are required [1,40]. However, in the case of rUTI, several randomized controlled trials with a large number of participants suggested that cranberry products might be efficient in specific populations (women with rUTI and children).…”

Section: Vaccinium Macrocarpon-cranberrymentioning

confidence: 99%

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Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections

Dinu

Vamanu

2022

Applied Sciences

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Urinary tract infections (UTI) represent one of the most widespread infections, and frequent recurrent episodes, induced mostly by uropathogenic Escherichia coli, make them increasingly difficult to treat. Long-term antibiotic therapy is an effective approach to treat recurrent UTI but generates adverse effects, including the emergence of pathogenic strains resistant to the vast majority of antibiotics. These drawbacks have enhanced the interest toward new alternatives based on natural remedies to prevent and treat recurrent UTI, especially in a synergistic antibiotic approach. Therefore, this review highlights the potential of some medicinal plants to be used in the management of recurrent UTI, including plants that have been approved for the treatment of urinary infections and promising, but less studied, plant candidates with proven anti-uropathogenic activity. Pomegranate (Punica granatum L.), black chokeberry (Aronia melanocarpa Michx.), and cornelian cherry (Cornus mas L.) have great potential to be used for prevention or in a combined antibiotic therapy to cure UTI, but more studies and clinical trials in specific population groups are required. Further progress in developing plant-based products to cure rUTI will be supported by advances in UTI pathogenesis and human-based models for a better understanding of their pharmacological activities.

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“…The present review covers plants with recognized anti-uropathogenic activities and promising medicinal plants that can treat infection recurrence but are less studied [39,40].…”

Section: Management Of Recurrent Uti By Non-antibiotic Plant-based Pr...mentioning

confidence: 99%

Section: Vaccinium Macrocarpon-cranberrymentioning

confidence: 99%

Section: Vaccinium Macrocarpon-cranberrymentioning

confidence: 99%

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Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections

Dinu

Vamanu

2022

Applied Sciences

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“…NAC has strong antioxidant potential as a powerful treatment agent, attenuating oxidative stress-induced cell injury and other pathological events, and is most frequently used in clinical and experimental research despite its classic use as a mucoactive agent 30 . Cela et al have summarized the nephroprotective effects of NAC in their work and pointed out that NAC could be used as an adjuvant treatment ingredient in urinary tract infections to reduce antibiotic drugs nephrotoxic adverse reactions 31 , 32 . These results provided more support that NAC has great clinical value as a renal protective agent of vancomycin.…”

Section: Discussionmentioning

confidence: 99%

N-acetylcysteine Ameliorates Vancomycin-induced Nephrotoxicity by Inhibiting Oxidative Stress and Apoptosis in the in vivo and in vitro Models

Yu¹,

Luo²,

Song³

et al. 2022

Int. J. Med. Sci.

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Background: Oxidative stress-related apoptosis is considered as the key mechanism implicated in the pathophysiology of nephrotoxicity with vancomycin (VCM) therapy. We evaluated the possible effects of N-acetylcysteine (NAC) on VCM-induced nephrotoxicity and the underlying mechanism. Methods: VCM-induced nephrotoxicity was established using HK-2 cells and SD rats and observed by measuring cell survival, kidney histological changes, renal function and kidney injury related markers (KIM-1 and NGAL). Oxidative stress, renal cell apoptosis and the involved signaling pathways were also evaluated. Results: In model rats, NAC could protect against VCM-induced acute kidney injury with histological damage, renal dysfunction, and increased Cre and BUN levels. In HK-2 cells, VCM-induced decreased cell viability was restored by NAC. In addition, increased expression of caspase-3, KIM-1 and NGAL suffering from VCM was also reversed by NAC in vivo and in vitro . NAC inhibited ROS production, decreased cell apoptosis by decreasing the Bax/Bcl-2 ratio and caspase-3 expression in HK-2 cells and regulated oxidative stress indicators in the kidney by decreasing GSH, SOD and CAT activity and increasing MDA levels. Furthermore, NAC could effectively reverse VCM-associated increased P38 MAPK/JNK phosphorylation. Conclusions: The results demonstrated that NAC had a protective effect against nephrotoxicity from VCM by inhibiting oxidative stress and apoptosis via P38 MAPK/JNK.

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“…In these forms it is excreted by the kidney. In case of a lower urinary tract infection, the conjugates are hydrolysed in the urinary bladder [ 16 ] and the formed hydroquinone shows antibacterial effects [ 17 ]. While β-arbutin is sometimes also used as skin brightener [ 18 ], α-arbutin has not been used for treatment of lower urinary tract infections.…”

Section: Introductionmentioning

confidence: 99%

Quantification of Arbutin in Cosmetics, Drugs and Food Supplements by Hydrophilic-Interaction Chromatography

2022

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Arbutin, the glucoside of hydroquinone, exists in two isomers, α-arbutin and β-arbutin. The synthetic α isomer is mainly used as a skin brightening agent, while β-arbutin occurs naturally, for instance in bearberry, and is used in drugs for treatment of lower urinary tract infections and as a food supplement. Since both isomers can be harmful at high concentrations, methods for their quantification are required. Classically they have been determined by reversed-phase chromatography, but separation of both isomers is often unsatisfactory. Here we present a simple and reliable method for quantification of α- and β-arbutin based on hydrophilic-interaction chromatography. Prior to analysis, interfering compounds that would frequently be present in cosmetics and drugs, particularly biopolymers, were efficiently removed by precipitation with acetonitrile. In this paper, for separation, a Cyclobond I 2000 5 µm 250 × 4.6 mm column was employed as stationary phase and acetonitrile/water 92/8 (v/v) was used as an eluent at a flow rate of 0.8 mL min−1. For quantification, a UV detector operating at 284 nm was applied. Although analysis took less than 10 min, baseline separation of α- and β-arbutin was achieved. The response was highly linear (r > 0.999) and the method had, for both α- and β-arbutin, a LOD of 0.003% (w/w) and a LOQ of 0.009% (w/w). Moreover, the method showed excellent intra-day and inter-day repeatability with relative standard deviations in the range of 0.5% to 2.3% and 1.0% to 2.2%, respectively, with cosmetics, drugs and food supplements as samples.

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A Natural Alternative Treatment for Urinary Tract Infections: Itxasol©, the Importance of the Formulation

Cited by 6 publications

References 119 publications

Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections

Novel Insights on Plant Extracts to Prevent and Treat Recurrent Urinary Tract Infections

N-acetylcysteine Ameliorates Vancomycin-induced Nephrotoxicity by Inhibiting Oxidative Stress and Apoptosis in the in vivo and in vitro Models

Quantification of Arbutin in Cosmetics, Drugs and Food Supplements by Hydrophilic-Interaction Chromatography

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