“…Better magnification microscopes, advances in anatomic knowledge of peripheral nerves topography and a better understanding of the pathophysiology of nerve injury have all led to a decisive leap forward in the management of this condition 3,4 . Refined microsurgical techniques 5,6 such as neurorrhaphies (end-to-end, end-to-side, side-to-side, supercharging), neural neurotization, nerve transfer, nerves conduits, and others were developed; However, despite the encouraging results obtained when analyzing the technical, histological and electrophysiological parameters; these parameters normally do not correlate with the return of the functional recovery 3,5,7,8 , making the treatment of peripheral nerve injury a challenge to actual medicine.…”