Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats

Teixeira, Renan Kleber Costa; Calvo, Faustino Chaves; Santos, Deivid Ramos dos; Araújo, Nayara Pontes de; Tramontin, Daniela Ferreira; Costa, Luís Vinícius Pires da; Barros, Rui Sergio Monteiro de

doi:10.1590/s0102-865020200070000002

Cited by 4 publications

(6 citation statements)

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“…It is known that in humans the long thoracic nerve emerges from the roots of C5 to C7 1 , 2 , which differs from what was found in our study since in the 10 animals dissected, this nerve was not identified, suggesting that there may be another origin and that should be revisited.…”

Section: Discussioncontrasting

confidence: 97%

“…A great example of this is the scarce or absent contribution of the ulnar nerve in the flexor muscles of the forepaw, being the median nerve responsible for this function, disagreeing with the studies in humans in which the ulnar nerve shares this function together with the median nerve. Thus, experimental studies that aim to evaluate the ulnar nerve and its impact on paw flexion may be biased 2 , 4 , 15 .…”

Section: Discussionmentioning

confidence: 99%

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Anatomorphometry of the brachial plexus under high-definition system: an experimental study in rats

et al. 2022

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Purpose: To study the anatomorphometry of the plexus brachialis (PB) of rats under a high-definition video system. Methods: Ten male Wistar rats discarded from other research that did not interfere in the morphology of the animal, respecting the principle of reduction, were used. All animals were submitted to the same protocol. Initially, the cervical region was shaved. The animals were placed in a dorsal position. A single elbow-to-elbow incision was performed and dissection started at the deltopectoral sulcus. The procedures were performed under a video system. To measure the structures, the Image J software was used. Results: All the PB evaluated originated from the C5-T1 spinal nerves. C5 and C6 converged to form the truncus superior, the root of C7 originated the truncus medius, and the confluence of C8 and T1 originated the truncus inferior. It was found the union of C7, C8, and T1 to form truncus inferomedialis instead of separate medial and inferior truncus. C8 (1.31 mm) was the thickest root, the truncus inferior (1.80 mm) and the nerve radialis (1.02 mm), were the thickest. Conclusions: The anatomy of the PB is comparable to humans, admitting variations. The videomagnification system is useful to perform microsurgical dissection.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Anatomorphometry of the brachial plexus under high-definition system: an experimental study in rats

et al. 2022

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“…Different species of animals are used in the study of nerves, including primates, dogs, cats, rats, mice, and rabbits 1 – 3 , 16 . The choice of the rat was due to ease of access and handling 17 . These animals have anatomical structures similar to humans and suitable for various studies 5 – 8 .…”

Section: Discussionmentioning

confidence: 99%

“…The increased number of fascicles that make up the spinal nerves of the cervical and brachial plexus may be explained by the need for a large number of neural tissues to supply the forelimbs of the animals 17 , 24 , 25 .…”

Section: Discussionmentioning

confidence: 99%

Anatomical description of the ventral and dorsal cervical rootlets in rats: A microsurgical study

et al. 2022

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Purpose: To describe the anatomical aspects of the cervical rootlets and to quantify the number of rootlets that compose C1 to T1. Methods: Twenty male rats were used in this study. The dorsal rootlets from C1 to T1 were analyzed. To study the ventral rootlets, the posterior root avulsion was performed using a microhook, allowing exposure of the ventral roots through manipulation of the denticulate ligament and arachnoid mater. The parameters analyzed were the number of ventral and dorsal rootlets by side and level. Results: The formation of the respective spinal nerve was observed in the spinal roots the union of the ventral and dorsal roots. In four animals the C1 spinal root had no dorsal and/or ventral contribution. There is no normal pattern of numerical normality of the dorsal and ventral rootlets. The average number of fascicles per root was 4.08, with a slight superiority on the left side. There was a slight superiority of the dorsal rootlets compared to the ventral rootlets. Conclusions: This investigation was the first to study cervical rootlets in rats. In 20% of the sample studied, the dorsal root of C1 was absent mainly on the left side. There is a nonlinear numerical increase from C1 to T1 in the rootlets. There is a numerical predominance of cervical fascicles on the left side, confronting several studies related to the functional predominance of right laterality, requiring new studies that correlate these variables.

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“…According to scores of Rat Grimace Scale, better postoperative recovery was found in animals submitted to the new anesthetic protocol, mainly in first and third days after surgery, similar to that reported in other studies 13 , 25 . The pain scale has high sensitivity in the immediate postoperative period and, although its decrease does not necessarily mean spontaneous pain resolution, its application serves to refine our understanding of the best surgical recovery of the experiments 24 , 27 .…”

Section: Discussionmentioning

confidence: 99%

A new anesthetic protocol to medullary nerve roots access in rats

et al. 2021

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Criteria for assessing peripheral nerve injury. Behavioral and functional assessment in non-operated Wistar rats

Abstract: Conception, design, intellectual and scientific content of the study; interpretation of data; statistical analysis; critical revision.

Cited by 4 publications

References 33 publications

Anatomorphometry of the brachial plexus under high-definition system: an experimental study in rats

Anatomorphometry of the brachial plexus under high-definition system: an experimental study in rats

Anatomical description of the ventral and dorsal cervical rootlets in rats: A microsurgical study

A new anesthetic protocol to medullary nerve roots access in rats

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