Oral lichen planus: study of 21 cases

Werneck, Juliana Tristão; Costa, Taiara De Oliveira; Stibich, Christian Abreu; Leite, Cristhiane Almeida; Dias, Eliane Pedra; Silva, Arley

doi:10.1590/abd1806-4841.20153704

Cited by 21 publications

(20 citation statements)

References 25 publications

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“…Similar results were reported in previous studies (28). The higher detection ratio of C. albicans in OLP might be associated with the use of steroids for treating these lesions (28,29). Unexpectedly, we found a relatively low fungal detection ratio in oral candidiasis samples.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Rapid detection of <i>Candida albicans</i> in oral exfoliative cytology samples by loop-mediated isothermal amplification

Noguchi

Igarashi

Omagari

et al. 2017

Journal of Oral Science

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Loop-mediated isothermal amplification(LAMP) rapidly amplifies DNA under isothermal conditions. The aim of this study was to detect Candida albicans and compare the positivity rate in the LAMP reaction with that of conventional methods for oral exfoliative cytology (EC) samples. Sixty-eight EC samples from 53 patients were subjected to LAMP analysis. These patients had been clinically diagnosed with leukoplakia, squamous cell carcinoma, oral lichen planus (OLP), stomatitis, oral candidiasis, and other malignancies. LAMP reactions were defined as positive when the sample turbidity exceeded 0.1 (arbitrary unit). Periodic acid-Schiff (PAS) staining and microbial culture were also performed to detect Candida species in EC samples. The LAMP reaction detected C. albicans in 42.6% of EC samples. Candida species were detected in 32.4% of the same samples by culturing and in 29.4% of samples by PAS staining. C. albicans DNA was detected most frequently in samples from OLP patients. We conclude that, in comparison to conventional methods for detection of C. albicans, the LAMP method is highly sensitive and timesaving, and does not require expensive equipment or diagnostic technology. It may therefore be useful for on-site screening of C. albicans at dental clinics.

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Section: Discussionsupporting

confidence: 92%

“…The highest C. albicans positivity was observed for OLP samples (85.7%), which may suggest an appropriate treatment plan for these lesions using steroids. Similar results were reported in previous studies (28). The higher detection ratio of C. albicans in OLP might be associated with the use of steroids for treating these lesions (28,29).…”

Section: Discussionsupporting

confidence: 90%

Rapid detection of <i>Candida albicans</i> in oral exfoliative cytology samples by loop-mediated isothermal amplification

Noguchi

Igarashi

Omagari

et al. 2017

Journal of Oral Science

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“…Several studies report the malignant potential of OLP. 27 We also observed a significant association between the GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. OL was the most common lesion in tobacco users, and OSCC is usually preceded by OL after repeated insults of carcinogens and tobacco.…”

Section: Discussionsupporting

confidence: 56%

Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients

et al. 2017

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The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in Argentine patients.

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“…Lichen planus is a chronic mucocutaneous inflammatory disorder that is estimated to affect 0.5%‐2.2% of the general population . The cause is unknown in most cases; however, in a minority of patients, precipitating factors have been suggested, including dental materials, drugs, stress, and infectious agents .…”

Section: Introductionmentioning

confidence: 99%

Topical hyaluronic acid in the management of oral lichen planus: A comparative study

Hashem

Issrani

Elsayed

et al. 2018

J of Invest & Clin Dent

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Lichen planus is a chronic mucocutaneous inflammatory disorder that is estimated to affect 0.5%-2.2% of the general population. 1 The cause is unknown in most cases; however, in a minority of patients, precipitating factors have been suggested, including dental materials, drugs, stress, and infectious agents. 2 It primarily affects middleaged adults, and the prevalence is greater among women. There are four forms of oral lichen planus (OLP) that relate to clinical appearance: reticular, atrophic, bullous, and erosive. 3 Symptoms arising from OLP vary markedly and often relate to the specific category.Patients with an atrophic/erosive form of OLP often present with symptoms ranging from burning sensation to severe pain, interfering with speaking, eating, and swallowing. 4Patients with symptomatic OLP often require therapy and should be treated if symptoms are significant. 5 Various treatments have Abstract Aim: Oral lichen planus (OLP) is a chronic mucocutaneous disorder seen in clinical dental practice. Despite the progress in research and advances in knowledge, the successful management of OLP is still difficult to achieve. The aim of the present study was to compare the therapeutic effects of triamcinolone (TA) preparation (0.1%) with hyaluronic acid (HA) preparation (0.2%) in the management of OLP. Methods:In total, 40 patients of any age or sex who had symptomatic OLP were selected and randomly divided into two groups. Group I received topical 0.1% TA, and group II received topical 0.2% HA preparation three times per day for a period of 4 weeks. Basement data were recorded for each patient. Patients were evaluated on days 14 and 21, and after completing the course of treatment. The visual analog scale (VAS) was used for evaluating pain and burning sensation, along with an evaluation of the degree of erythema and mean area of the lesion. Data were analyzed by SPSS 17.0 software using Mann-Whitney and t test. P ≤ 0.05 was considered statistically significant. Results:Our results showed considerable improvement in all of the parameters evaluated. Baseline characteristics, including pain score, size, and clinical characteristics of the lesions, were not different between the two treatment groups. Both TA and HA were found to reduce the VAS score, the degree of erythema, and size of the lesions after treatment. Conclusion:The application of HA is suggested, and is an effective substitute for TA in the treatment of OLP. K E Y W O R D Scorticosteroid, hyaluronic acid, mucocutaneous, oral lichen planus, triamcinolonePatients were asked to return to the clinic for review at 14, 21, and 28 days' post-baseline. During these visits, any changes in the VAS values and site of lesion, color, size, or appearance of the lesions were duly noted on the proforma. The entire data were then entered into the proforma. | Statistical analysisAll data were tabulated and analyzed using SPSS version 17.0 (Chicago, IL, USA). The results are presented as mean ± standard deviation. Comparison between the groups for VAS and degree of erythe...

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Oral lichen planus: study of 21 cases

Cited by 21 publications

References 25 publications

Rapid detection of <i>Candida albicans</i> in oral exfoliative cytology samples by loop-mediated isothermal amplification

Rapid detection of <i>Candida albicans</i> in oral exfoliative cytology samples by loop-mediated isothermal amplification

Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in Argentine patients

Topical hyaluronic acid in the management of oral lichen planus: A comparative study

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