Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice

Abstract

INTRODUCTION:We investigated the antianxiety and sedative effects of the essential oil of Ducrosia anethifolia. Boiss. (Apiaceae).METHODS:We used elevated plus maze, spontaneous motor activity and ketamine‐induced sleep tests in mice. In addition, the essential oil was analyzed by GC/MS. Twenty compounds were identified, and n‐decanal (70.1%) and alpha‐pinene (12.4%) constituted the major components.RESULTS:In elevated plus maze, Ducrosia anethifolia essential oil at doses of 25–200 mg/kg increased the percentage of open arm time and entries. Unlike diazepam, ducrosia anethifolia essential oil could not suppress spontaneous motor activity and did not alter ketamine‐induced sleep parameters. These results are indicative of antianxiety effect of Ducrosia anethifolia essential oil without sedative effect.

Effects of inhaled juniper volatile oil in amyloid beta (1‐42)‐induced anxiety and depression in laboratory rats

“…As expected, diazepam (DZP) as a benzodiazepine drug produced significant increases in the percentage of time spent in the open arms and the number of open‐arm entries of Aβ(1‐42)‐treated rats. These data are consistent with the results of numerous previous studies, which have shown that DZP and other benzodiazepines produce significant anxiolytic effects in a variety of anxiolytic screening procedures, including elevated plus‐maze test procedures . Benzodiazepines mainly exert their antianxiety effects via interaction with gamma‐amino‐butyric acid (GABA) receptors .…”

Mosquitocidal and repellent activities of essential oils against Culex pipiens L.

“…). The oil of D. anethifolia contains decanal, chrysanthenyl acetate, dodecanal, and α‐pinene as the major constituents; similar results were reported by Hajhashemi et al () for samples collected from Kerman, Iran. Moreover, Mostafavi et al () recorded decanal, chrysanthenyl acetate, and pinene as major compounds; however, Yan et al () reported citronellal, limonene, linalool, and myrcene for samples collected from Iran.…”

Antidepressant activity of Litsea glaucescens essential oil: Identification of β-pinene and linalool as active principles

“…A number of studies report that essential oils have activity on central nervous system in animal models, for example showing antiinflammatory and antinociceptive (Raymundo et al, 2011), anticonvulsant (de Almeida et al, 2011, sedative, anxiolytic effects (Hajhashemi et al, 2010), among others. Also, some constituents of essential oils, for instance linalool (Linck et al, 2010), and a-terpineol (Quintans-Jú nior et al, 2011) have sedative activity in humans and antinociceptive activity in mice, respectively.…”