Antidepressant activity of Litsea glaucescens essential oil: Identification of β-pinene and linalool as active principles

Subchronic Administration of Linalool Decreases Depressive-Like Behaviour in Restrained Rats

“…The present study showed that the injection with linalool 500 mg/kg in stressed rats for two weeks reduced immobility times but increased climbing times when compared to their controls suggesting that this dose produced antidepressant activity. Our results are consistent with a previous study demonstrating that the acute administration of linalool showing antidepressant-like activity in the FST on mice [14].…”

“…A recent study has shown that linalool is a neuroprotective agent against acrylamide-induced neurotoxicity in rats [13]. The intraperitoneal injection of linalool significantly decreased the immobility time, an index of the depressive-like behaviour using the FST of mice as compared with the vehicle [14].…”

Anxiolytic-like effect of Lippia alba essential oil: A randomized, placebo-controlled trial

“…In the case of limonene, a study suggests a non-benzodiazepine mechanism [36]. Meanwhile linalool has antagonistic action on glutamatergic receptors such as N-methyl-Daspartate receptors, which may explain its sedative effect [37].…”

Morfo-anatomía foliar de Alvaradoa amorphoides Liebm. del estado de Morelos (México)

“…La síntesis de este tipo de compuestos está relacionada con su actividad antioxidante que inhibe las especies reactivas de oxígeno formadas durante eventos de estrés en la planta (Rice-Evans et al, 1995;Yan et al, 2000;Evert, 2006;Guzmán-Gutiérrez et al, 2012). Asimismo el movimiento paraheliotrópico es un fenómeno que disminuye el impacto de los rayos solares sobre las superficies de la hoja (Jones, 1992 al., 2013), sin embargo ocasiona estrés mecánico (Moysset y Simon, 1991) por lo que también la presencia de estos compuestos en el colénquima del pecíolo, del peciólulo y del folíolo sugiere, adicionalmente a la desintoxicación celular, el reforzamiento mecánico y la impermeabilización de estas zonas de la hoja.…”