The effect of alcohol consumption on periodontal bone support in experimental periodontitis in rats

Souza, Daniela Martins de; Ricardo, Lucilene Hernandes; Prado, Marcela de Almeida; Prado, Fernanda de Almeida; Rocha, Rosilene Fernandes da

doi:10.1590/s1678-77572006000600010

Cited by 30 publications

(40 citation statements)

References 28 publications

(35 reference statements)

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“…26 A recent study observed that, in male rats, periodontitis induction led to greater periodontal bone destruction when associated with alcohol intake at concentrations of 10%, 20% and 30%. 27 Compared to the present study, these results suggest that the effects of alcohol consumption in male rats may be observed in lower concentration of ethanol than in female rats.…”

Section: Discussioncontrasting

confidence: 86%

Influence of alcohol consumption on alveolar bone level associated with ligature-induced periodontitis in rats

Souza¹,

Ricardo

Kantoski

et al. 2009

Braz. oral res.

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Alcohol consumption is a risk indicator for periodontal disease. The purpose of this study was to morphometrically evaluate the influence of alcohol consumption on alveolar bone level associated with ligature-induced periodontitis in rats. Thirty-six female rats (Wistar, 120 days-old) were randomly divided into three groups that received a daily administration of a water diet (control, n = 12), a 10% alcohol diet (10% ethanol, n = 12) or a 20% alcohol diet (20% ethanol, n = 12). Four weeks after the onset of the experiment, cotton ligatures were placed around the cervix of the upper right second molar in six rats. The other 6 rats in each group remained unligated. The rats were sacrificed four weeks after ligature placement. The maxillary bones were removed and alveolar bone loss was analyzed by measuring the distance between the cementoenamel junction and the alveolar bone crest at 2 buccal and 2 palatal sites on the upper right second molar. Analyses between the ligated and unligated groups showed that the presence of ligature induced alveolar bone loss (p < 0.05). Unligated groups showed no significant differences between each other (p > 0.05). In the ligated groups, rats receiving 20% ethanol showed significantly greater bone loss compared to control rats or rats receiving 10% ethanol. These results demonstrate that alcohol consumption may increase alveolar bone loss in female rats in a dosedependent manner.

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Section: Discussioncontrasting

confidence: 86%

Influence of alcohol consumption on alveolar bone level associated with ligature-induced periodontitis in rats

Souza¹,

Ricardo

Kantoski

et al. 2009

Braz. oral res.

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“…Research suggests that alcohol consumption is associated with the increase of severity of periodontitis in humans [4][5]19 , periodontal inflammation [14][15] and alveolar bone loss in periodontal disease in rats [11][12][13] . However, others studies on humans have shown no relation between periodontal disease and alcohol intake [9][10] .…”

Section: Discussionmentioning

confidence: 99%

“…However, more recent studies on humans have shown no relation between periodontal disease and alcohol consumption [6][7] . The use of rat models has been applied in the evaluation of periodontal pathogenesis 8 and regarding the influence of risk indicator/factors, such as estrogen deficiency [9][10] , alcohol consumption [11][12][13][14][15][16] , nicotine 17 and simultaneous nicotine and alcohol use 18 on disease progression.…”

Section: Introductionmentioning

confidence: 99%

Effects of alcohol intake in periodontitis progression in female rats: a histometric study

Souza¹,

Ricardo²,

Rocha³

2014

Braz. J. Oral Sci.

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Aim: To evaluate histometrically the effect of low and high caloric value of ethanol on ligatureinduced bone loss in female rats. Methods: Sixty female rats were divided into five groups of 12 animals each: Normal Control (water), Test A (low ethanol), Control A (low iso), Test B (high ethanol) and Control B (high iso). Control Groups A and B received diets with the same amount of calories consumed by Test Groups A and B, respectively, with ethanol replaced by isocaloric amounts of carbohydrate. Four weeks prior to the end of the experimental period, half of the rats in each group were randomly assigned to receive a ligature on mandibular molar, whereas the other half of group was left unligated. At 8 weeks, the animals were sacrificed, and the specimens were processed to obtain decalcified sections. The area of periodontal ligament and/or bone loss in the furcation region of the first molars was histometrically measured in five sections per specimen (mm²). Results: Ethanol intake did not have effect on the alveolar bone loss in unligated teeth (p>0.05). However, in ligature-induced periodontitis, high value of calories associated with ethanol feeding enhanced the area of bone loss (p<0.05). Conclusions: The results of this study demonstrated that a low-ethanol diet did not affect the periodontium, while a high-ethanol diet may aggravate the progression of periodontitis, as demonstrated by the increased furcation region bone destruction in periodontal disease.

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“…[7,19], and histologic [12] or histometric [9] analyses applied to jaws. However, the morphometric methods adopted to assess alveolar bone level are not capable of detecting intra-osseous defects.…”

Section: Discussionmentioning

confidence: 99%

“…Heavy drinking episodes are associated with detrimental consequences, even when the mean alcohol consumption level is relatively low [1]. Some studies [9,10,18,19,[21][22][23][24] showed that alcohol intake itself might not be capable of causing bone loss in rats' periodontium. On the other hand, other studies [25,26] recorded that chronic alcohol drinking itself may cause bone loss in rats.…”

Section: Discussionmentioning

confidence: 99%

Alveolar bone loss induced by high alcohol consumption in rats

Souza

Silva

Pereira

et al. 2017

BDS

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42 ResumoObjetivo: O objetivo do presente estudo foi avaliar o efeito do consumo regular e constante de álcool em longo prazo na porcentagem do suporte ósseo periodontal remanescente (SOP) e perda óssea periodontal (PO) em ratos adultos. Material e Métodos: Cinquenta e quatro (54) ratos foram divididos em 3 grupos: Controle (ingestão diária de água, n = 18), consumo diário de álcool (20% etanol, n = 18) e consumo social de álcool (20% etanol 2x por semana, n = 18). Os ratos foram tratados com acesso de livre escolha a ambas as frequências de consumo de etanol. Eles foram sacrificados após 90 dias e suas mandíbulas esquerdas foram radiografadas para medição do SOP. As mesmas mandíbulas esquerdas foram dissecadas e coradas. A PO foi avaliada morfometricamente medindo a distância entre a junção cimento-esmalte e a crista óssea alveolar. Resultados: Não houve diferença (p> 0,05) na quantidade de álcool consumido entre os grupos de ingestão diária e social. Os ratos também evidenciaram menor porcentagem de SOP e maior PO (p <0,05) em ambos os grupos de consumo de álcool em comparação com o controle. Conclusão: A mesma quantidade consumida constante e regular de álcool em longo prazo pode causar perda óssea alveolar e reduzir o suporte ósseo periodontal remanescente em ratos adultos. Assim, a perda óssea alveolar foi associada com a quantidade de álcool consumido, ao invés da periodicidade em ratos sem periodontite. ABsTRACTObjectives: The aim of the present study was to assess the effect of regular and constant longterm alcohol consumption on the percentage of the remaining periodontal bone support (PBS) and periodontal bone loss (PBL) in adult rats. Material and Methods: Fifty-four (54) rats were divided into 3 groups: Control (daily water intake, n=18) daily alcohol intake (20% ethanol, n=18) and social alcohol intake (20% ethanol 2x a week, n=18). The rats were treated with free-choice access to both ethanol consumption frequencies. They were euthanized after 90 days and their left mandibles were radiographed for PBS measuring. The same left mandibles were defleshed and stained. The PBL was morphometrically assessed by measuring the distance between cement-enamel junction and alveolar bone crest. Results: Did not show difference (p > 0.05) in the amount of consumed alcohol between the social and daily intake groups. Rats also evidenced lower PBS percentage and higher PBL (p<0.05) in both alcohol consumption groups in comparison to the control. Conclusion: The long-term constant and regular same amount alcohol consumption may cause alveolar bone loss and reduce the remaining periodontal bone support in adult rats. Thus, the alveolar bone loss was associated with the amount of consumed alcohol, rather than with periodicity in periodontitis-free rats.

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The effect of alcohol consumption on periodontal bone support in experimental periodontitis in rats

Cited by 30 publications

References 28 publications

Influence of alcohol consumption on alveolar bone level associated with ligature-induced periodontitis in rats

Influence of alcohol consumption on alveolar bone level associated with ligature-induced periodontitis in rats

Effects of alcohol intake in periodontitis progression in female rats: a histometric study

Alveolar bone loss induced by high alcohol consumption in rats

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