Estudo morfométrico e morfológico da cicatrização após uso do laser erbium: YAG em tecidos cutâneos de ratos

Abstract

de ablação (>>) que é representado pela ausência completa da epiderme (e) e da derme papilar (p) quando se compara com a porção não-lesada da pele. Na Figura 2 (detalhe da Figura 1) observa-se o dano térmico residual (d) representado por faixa de tecido compacto e homogêneo em vermoelho-escuro. As Figuras 3 a 8 devem ser analisadas comparativamente onde a fibroplasia (F) representada por faixa colágena vai progressivamente aumentando. Observe que na Figura 3 a fibroplasia compromete apenas a derme papilar (p). Já nas Figuras 4 e 5 a fibroplasia (F) compromete derme papilar (p) e porções superficiais da derme reticular (r). Se analisarmos as Figuras 6, 7 e 8, observamos que a fibroplasia (F) atinge a derme papilar (p) e toda a porção superficial da derme reticular (r), indo até a derme reticular média na Figura 8.

Fibroplasia after polypropylene mesh implantation for abdominal wall hernia repair in rats

“…Collagen was detected on the polypropylene mesh earlier than had been described in the literature 15,25 , at a higher percentage mean than that observed by Souza Filho et al 26 , with a decrease in its percentage amount after the 21st day, which is not consistent with the results obtained by other authors for muscle and skin repair 21,25 . Fibroplasia on skin wounds occurs approximately 5 days after tissue injury and may last for up to 2 weeks 11,14,16,22 .…”

“…Fibroplasia on skin wounds occurs approximately 5 days after tissue injury and may last for up to 2 weeks 11,14,16,22 . Noronha et al 25 analyzed skin repair in rats after laser application and observed fibroplasia on the 7th day after the procedure, with a sharp increase up to the 28th day, reaching a plateau and then remaining so until the end of the study period (112th day). Klinge et al 15 described the appearance of collagen fibers on polypropylene meshes in rats after the 7th postoperative day.…”

Análise da dose do laser de baixa potência em equipamentos nacionais

“…Most studies on laser application for cicatrizing skin wounds show positive effects, as observed through the proliferation of fibroblasts and endothelial cells, and increased deposition of collagen and keratin 4,[12][13][14][15] . However, there is great variation in relation to the ΔE used, and the values found ranged from 1 to 21.4 J/cm 2 (12,15) .…”

Morphological analysis of three wound-cleaning processes on potentially contamined wounds in rats

“…The rat was the experimental animal of choice because of factors such as easy obtention, handling and maintenance aside from a lesser morbidity and mortality, as they are animals of proven strength, even in an adverse environment. 27 Another advantage in the use of rats is the smaller amount of elastic fibers found on the corium 28 , since there was no interest in the study of collagen, allowing researchers to study the greater or lesser inflammatory process depending on the antisseptic agent envolved. In this experimental model the choice was to conduct the suture in all animals, in order to protect the spot from other bacteria which the wound might get in contact with otherwise, and to have a better correlation with what happens in the daily routine of human emergency wards.…”