The side-effects of different doses of iron sulfate on women of reproductive age: a randomized double-blind, placebo-controlled study

Machado, Katia Maria de Melo; Ferreira, Luiz Oscar Cardoso; Souza, Ariani Impieri de; Diniz, Alcides da Silva

doi:10.1590/s1519-38292011000300008

Cited by 3 publications

(2 citation statements)

References 16 publications

(33 reference statements)

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“…With respect to the weekly supplementation, although it eliminates the most undesirable gastrointestinal effects found with the daily use of prophylactic supplementation, some problems related to its use remain 21 : it cannot be ignored that the daily or weekly supplement is a medication that should be used for prolonged and repeated regularly with a view to maintain a situation of normality in relation to biochemical indicators of iron deficiency. In turn, the deployment of such prophylaxis requires an operating system suitable for distribution of the supplement, which, even for the most vulnerable population groups, is far from being achieved.…”

Section: Discussionmentioning

confidence: 99%

Eficácia Do Ferro Suplementar Adicionado Às Refeições No Controle Da Anemia

Szarfarc

Marchioni

2019

Revista E-Ciência

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A elevada prevalência da deficiência de ferro e a baixa eficácia dos programas institucionais para seu controle, juntamente com os resultados positivos obtidos utilizando o ferro de forma intermitente ou incorporando o mineral rotineiramente a um alimento básico, serviram de base para o estabelecimento do objetivo deste estudo: avaliar o impacto resultante do uso semanal de suplemento marcial quando incorporado ao alimento durante seu preparo. O trabalho foi desenvolvido entre 98 pré-escolares que freqüentavam uma creche pública, com idades entre 6 e 60 meses de idade. Uma vez por semana, 4,2mg de Fe (ferro bis-glicina quelato-Ferrochel®) foram incorporados ao molho utilizado no preparo da cada 100g de macarronada. Nas 14 semanas de duração da intervenção, cada criança recebeu, em média, 2,9mg de ferro suplementar. A concentração da hemoglobina [Hb] utilizada para o diagnóstico da anemia foi medida no início e no final da intervenção. Verificou-se um aumento significativo na [Hb] e uma diminuição, também significativa na prevalência de anemia. O método de intervenção mostrou-se simples, extremamente econômico e de fácil aplicação, uma vez que, qualquer alimento pode ser utilizado como veículo do ferro suplementar com bons resultados, desde que, como o Ferrochel®,. tenha um ferro bem absorvível e cujas características físico-químicas permitam a manutenção das qualidades organolépticas da preparação dietética. Palavras chaves: deficiência de ferro, fortificação de alimentos, ferro quelato, suplementação semanal, efetividade.

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Section: Discussionmentioning

confidence: 99%

Eficácia Do Ferro Suplementar Adicionado Às Refeições No Controle Da Anemia

Szarfarc

Marchioni

2019

Revista E-Ciência

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“…It may have the advantage that reduced amounts of ingested iron may reduce proliferation of pathogenic gut bacteria, produce less oxidative stress and increase tolerability and adherence [14]. In addition, iron as NaFeEDTA has been reported to cause less oxidative stress than an equimolar dose of iron as ferrous sulphate [15].…”

Section: Introductionmentioning

confidence: 99%

Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children

Teshome

Andang’o

Osoti

et al. 2017

BMC Med

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BackgroundWe aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ferrous fumarate in Kenyan children aged 12–36 months. In addition, we updated a recent meta-analysis to assess the efficacy of home fortification with iron-containing powders, with a view to examining diversity in trial results.MethodsWe gave chemoprevention by dihydroartemisinin-piperaquine, albendazole and praziquantel to 338 afebrile children with haemoglobin concentration ≥70 g/L. We randomly allocated them to daily home fortification for 30 days with either placebo, 3 mg iron as NaFeEDTA or 12.5 mg iron as encapsulated ferrous fumarate. We assessed haemoglobin concentration (primary outcome), plasma iron markers, plasma inflammation markers and Plasmodium infection in samples collected at baseline and after 30 days of intervention. We conducted a meta-analysis of randomised controlled trials in pre-school children to assess the effect of home fortification with iron-containing powders on anaemia and haemoglobin concentration at end of intervention.ResultsA total of 315 children completed the 30-day intervention period. At baseline, 66.9% of children had inflammation (plasma C-reactive protein concentration >5 mg/L or plasma α 1-acid glycoprotein concentration >1.0 g/L); in those without inflammation, 42.5% were iron deficient. There was no evidence, either in per protocol analysis or intention-to-treat analysis, that home fortification with either of the iron interventions improved haemoglobin concentration, plasma ferritin concentration, plasma transferrin receptor concentration or erythrocyte zinc protoporphyrin-haem ratio. We also found no evidence of effect modification by iron status, anaemia status and inflammation status at baseline. In the meta-analysis, the effect on haemoglobin concentration was highly heterogeneous between trials (I 2: 84.1%; p value for test of heterogeneity: <0.0001).ConclusionsIn this population, home fortification with either 3 mg iron as NaFeEDTA or 12.5 mg iron as encapsulated ferrous fumarate was insufficiently efficacious to assess non-inferiority of 3 mg iron as NaFeEDTA compared to 12.5 mg iron as encapsulated ferrous fumarate. Our finding of heterogeneity between trial results should stimulate subgroup analysis or meta-regression to identify population-specific factors that determine efficacy.Trial RegistrationThe trial was registered with ClinicalTrials.gov (NCT02073149) on 25 February 2014.Electronic supplementary materialThe online version of this article (doi:10.1186/s12916-017-0839-z) contains supplementary material, which is available to authorized users.

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Daily iron supplementation for improving anaemia, iron status and health in menstruating women

Löw

Speedy

Styles

et al. 2016

Cochrane Database of Systematic Reviews

100

109

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The side-effects of different doses of iron sulfate on women of reproductive age: a randomized double-blind, placebo-controlled study

Abstract: Objectives:to identify side effects of the use of different doses of iron sulfate (IS).Methods

Cited by 3 publications

References 16 publications

Eficácia Do Ferro Suplementar Adicionado Às Refeições No Controle Da Anemia

Eficácia Do Ferro Suplementar Adicionado Às Refeições No Controle Da Anemia

Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children

Daily iron supplementation for improving anaemia, iron status and health in menstruating women

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