Effect of ractopamine on lipid metabolism in vivo - a systematic review

Ferreira, Matheus Soares da Silva; Garbossa, César Augusto Pospissil; Oberlender, Guilherme; Pereira, Luciano José; Zangerônimo, Márcio Gilberto; Sousa, Raimundo Vicente de; Cantarelli, Vinícius de Souza

doi:10.1590/s1516-89132013000100005

Cited by 24 publications

(26 citation statements)

References 40 publications

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“…In pigs, another action of ractopamine on fat metabolism is the promotion of lower fat accretion by reducing lipogenesis (Bergen, 2001), which could be explained by the reduction of the sensitivity on adipose tissue to insulin, as it happens in pigs under βAA stimulation, and an evidence of lipogenesis inhibition (Mills et al, 2002). Furthermore, according to recent works focusing on lipogenic gene expression in the adipose tissue of finishing pigs, ractopamine can reduce the RNA transcription of genes related to lipid synthesis, such as sterol regulatory binding protein-1 (SREBP-1), which is a transcriptional factor that drive genes involved in the synthesis of fatty acids (Horton et al, 2003) and fatty acid synthase (Reiter et al, 2007;Halsey et al, 2011), a key enzyme involved in the synthesis of fatty acids (Ferreira et al, 2013). Although no difference was found in the weight gain between control and treatment groups during the experimental period (average of 170 g) ( Table 3), considering that ractopamine may have more efficacy on blocking lipogenesis instead of stimulating lipolysis (Mills et al, 2003), the animals that received ractopamine may have had a decrease of lipogenesis rate, especially at 8 mg kg −1 of ractopamine.…”

Section: Discussionmentioning

confidence: 99%

“…This can occur when ractopamine is provided at a constant level over long periods, as a result of down-regulation or desensitization of βAR, or both (Moody et al, 2010;Almeida et al, 2012). This work adopted a 31-day experimental period based on swine experiments Amaral et al, 2009), although the effect of desensitization can occur earlier in pigs than in fish Ferreira et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Effect of ractopamine on Nile tilapia in the end of grow-out period

Tovo-Neto

Bittarello

Tovo³

et al. 2017

R. Bras. Zootec.

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-This experiment was conducted in outdoor tanks to evaluate the effect of inclusion of ractopamine at increasing levels (0, 4, 8, 12, and 16 mg kg −1 ) as additive in Nile tilapia (Oreochromis niloticus) diet in the final grow-out period (750-920 g) during 31 days. Therefore, 400 fish were housed into 20 experimental tanks, in a completely randomized design with five treatments and four replications. Growth performance, body yield, and chemical composition of fish muscle and organs were evaluated. Fish fed diets containing up to 16 mg kg −1 of ractopamine for 31 days did not improve growth or performance parameters. However, lipid percentage of abdominal muscle was different in fish fed ractopamine, reaching the lowest level of 199.3 g kg −1 of ether extract at 8 mg kg −1 treatment. Other body chemical composition parameters did not differ between animals treated or not treated. Feeding ractopamine up to 31 days has limited effect on body composition in Nile tilapia (~900 g), without any changes in growth parameters. This is a lower metabolic response in this species when compared with mammals and other terrestrial animals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of ractopamine on Nile tilapia in the end of grow-out period

Tovo-Neto

Bittarello

Tovo³

et al. 2017

R. Bras. Zootec.

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“…The method for defining the quality of the studies was based on other systematic reviews (Ferreira et al, 2013;Pereira, Oliveira, Mesquita, Costa, & Pereira, 2011;Silva et al, 2012). For each criterion, a punctuation system by scores was established, with score 2 assigned when the criterion was classified as adequate or clear and score 1 when it was inadequate or was not clearly described in the text.…”

Section: Quality Criteriamentioning

confidence: 99%

In ovo feeding of carbohydrates for broilers—a systematic review

Retes

Clemente

Neves

et al. 2017

Animal Physiology Nutrition

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SummaryThe purpose of this systematic review was to evaluate the evidence that the injection of carbohydrate-based solutions into embryonated eggs improves broiler performance. A literature search was conducted in April 2017 using the keywords broiler, carbohydrate, in ovo, nutrition and poultry. Only papers that involved in ovo carbohydrate injections in poultry were used in this study. After specific selection criteria, 17 papers were selected. The quality scoring system of the selected studies was based on the injection methodology, use of control groups, type of solution injected, period of injection, egg and hens characteristics, number of variables analysed and the statistical design. Among papers, there was no standardised procedure in to inoculate the solutions. Nevertheless, in general, in ovo feeding of carbohydrates decreases the hatch rate, improves the hatch weight, but it does not seem to influence the post-hatch performance of broilers. The inoculation of 75 mg of glucose in the albumen seems to bring better results. Further studies are needed to improve the technical methodology of in ovo injections for commercial use. K E Y W O R D Shatchability, in ovo nutrition, incubation, performance, poultry

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“…Ractopamine also reduces fat deposition in the carcass, by reducing lipogenesis and increasing lipolysis, which are its main mechanism of action (FERREIRA et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Ractopamine concentration on the lipid profile of swine fat and meat

et al. 2018

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This study was conducted to evaluate the effect of ractopamine concentrations on swine fat and meat lipid profiles. Ninety finishing barrows, initially weighing 71.9±4.4kg, were distributed in a randomized block design in three ractopamine concentrations (0, 10 and 20ppm) with fifteen replicates of two animals in each. Gas chromatography was used to analyze the lipid profiles of backfat and meat. The inclusion of ractopamine in the diet changed (P<0.05) α-linolenic acid and eicosatrienoic acid concentrations in the backfat but did not affect (P>0.05) any of the other fatty acids or indexes evaluated. In the meat, a significant effect (P<0.05) was observed on nine fatty acids evaluated, with a decrease (P<0.05) in lauric, myristic, and palmitic fatty acids, and an increase (P<0.05) in linoleic, γ-linolenic, dihomo-γ-linolenic, and eicosapentaenoic acid. Ractopamine also affected (P<0.05) the concentration of α-linolenic and arachidonic acid in the meat (P<0.05). The indexes evaluated were also affected (P<0.05). Addition of 10ppm decreased the saturated fatty acid concentration, atherogenic index, thrombogenic index and omega 6: omega 3, while it increased unsaturated and polyunsaturated fatty acids concentrations. Ractopamine addition had less effect on the backfat than on the meat, and the 10ppm level improved the meat lipid profile.

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Effect of ractopamine on lipid metabolism in vivo - a systematic review

Cited by 24 publications

References 40 publications

Effect of ractopamine on Nile tilapia in the end of grow-out period

Effect of ractopamine on Nile tilapia in the end of grow-out period

In ovo feeding of carbohydrates for broilers—a systematic review

Ractopamine concentration on the lipid profile of swine fat and meat

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