Biocompatibility, osteointegration, osteoconduction, and biodegradation of a hydroxyapatite-polyhydroxybutyrate composite

Reis, Emily Correna Carlo; Borges, Andréa Pacheco Batista; Fonseca, Cláudio César; Martínez, Mastoby Miguel Martínez; Eleotério, Renato Barros; Morato, Gláucia Oliveira; Oliveira, Paulo Miranda de

doi:10.1590/s1516-89132010000400010

Cited by 32 publications

(17 citation statements)

References 19 publications

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“…It was found to be biocompatible, osteoconductive and biodegradable, with no need for a second surgical operation to Nevertheless, biocomposites of these polymers with calcium orthophosphates show a good biocompatibility both in vitro and in vivo. 102,[409][410][411][412][413][414][415] Both bioactivity and mechanical properties of these biocomposites can be tailored by varying the volume percentage of calcium orthophosphates. Similarly, biocomposites of PHBHV with both HA and amorphous carbonated apatite (almost ACP) appeared to have promising potential for repair and replacement of damaged bones.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

149

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Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

149

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“…Therefore, hydroxyapatite is widely used in bone reconstruction [17][18][19][20] . However, hydroxyapatite has a critical disadvantage for use in dental implants because of its low modulus of elasticity and low fracture toughness 21) .…”

Section: Introductionmentioning

confidence: 99%

Osteoblast compatibility of materials depends on serum protein absorbability in osteogenesis

et al. 2012

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Titanium has an osseointegrative property, while hydroxyapatite has an osteoconductive property. It remains a matter of controversy among researchers whether hydroxyapatite has higher osteoblast compatibility than titanium. Here, we compared the activities between osteoblasts cultured on titanium and those cultured on hydroxyapatite. An osteoblast-like cell line, MC3T3-E1, was cultured on machined titanium, evaporated titanium, and hydroxyapatite disks to compare the affi nity of osteoblasts to each of these materials. The adhesion and proliferation of MC3T3-E1 cells were higher on hydroxyapatite disks than on the other disks. Osteoblast differentiation was not affected by the nature of disks investigated, but calcium was more easily deposited on the hydroxyapatite disks. The amount of absorbed serum proteins detected on hydroxyapatite was greater than that on titanium. In conclusion, our results indicate hydroxyapatite is a more suitable material for osteoblast growth than titanium because of its higher absorption of serum proteins.

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“…Furthermore, direct contact between the bone graft and bone indicated osteo integration 45 days after surgery. 20 Osteointegration was also observed in a study by James Mah et al, who used alloplast materials available in the market on rat calvarias. However, in their study, the available materials did not show significant bone growth when compared to the control group.…”

Section: Scientific Dental Journal 01 (2018) 09-17mentioning

confidence: 73%

The efficacy of fish scales as bone graft alternative materials

Soulissa

Nathania

2018

Sci Dent J

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Background: Bone graft application is a therapy that could be used to repair bone and minimize bone resorption. However, current bone graft materials carry risks for the recipient. Studies on alloplast, which can be found in fish bones and scales have been developed in the past few years. Objectives: This study aimed to determine the efficacy of hydroxyapatite powder from white barramundi (Lates calcarifer) fish scales as bone graft material in the mandibular defect regeneration of rats. Methods: This experimental laboratory study utilized 24 male Sprague-Dawley rats aged 16 weeks as test subjects, where 12 were used for control groups and the other 12 were used as the experimental group. All were given bone defects of 3 mm on the right mandible, split into 6 groups of 4 (3 experimental and 3 control groups), and the groups were observed for 2, 4, and 6 weeks respectively. The surgery results were assessed by radiography and histopathologic analysis. Result: Radiography results showed that the highest bone growth was found in the 6 weeks treatment group with 100% growth, followed by the 4 weeks treatment group with 88.89% growth, and last was the 2 weeks treatment group with 66.67% growth. The Mann-Whitney test showed that there is a significant difference between pre-and post-intervention (p >0.05). Histopathologic analysis showed the presence of osteocytes and osteoblasts in the 6 weeks treatment group. Conclusion: It can be concluded that hydroxyapatite powder from white barramundi fish scales can be used as a bone graft alternative material.

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Biocompatibility, osteointegration, osteoconduction, and biodegradation of a hydroxyapatite-polyhydroxybutyrate composite

Abstract: ABSTRACT

Cited by 32 publications

References 19 publications

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Osteoblast compatibility of materials depends on serum protein absorbability in osteogenesis

The efficacy of fish scales as bone graft alternative materials

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