Possible Associations between Bovine Growth Hormone Gene Polymorphism and Reproductive Traits

Abstract

The polymorphism of the bovine growth hormone gene (bGH) was studied in 211 Nellore pure breed males for association with reproductive traits. Scrotal circumference and testosterone concentrations were collected monthly from 10 until 16 months of age. Additionally, testicular growth rates were calculated. DNA was amplified by PCR and digested using Msp I and Hae III restriction enzymes. Every polymorphism presented two alleles. The predominant alleles were D (0.85) and F (0.98), respectively, and genotype EE - bGH/Hae III was missing. Significant association (P<0.05) between bGH/Msp I polymorphism, scrotal circumference and testicular growth after puberty, as well as between bGH/Hae III and testosterone concentrations at puberty were detected. The results suggested that these association could be useful for selection, since bGH/Msp I and bGH/Hae III polymorphisms could be considered as markers for testicular development after puberty and onset of puberty, respectively.

Association of polymorphisms in growth hormone and leptin candidate genes with live weight traits of Brahman cattle

“…Some of them include the bovine growth hormone (bGH), associated with carcass fat content and muscle yield, milk yield, and testicular development (Yao et al, 1996;Unanian et al, 2002); the receptor of bGH, associated with a large number of productive traits such as milk yield and composition (Viitala et al, 2006), feed consumption, and feed conversion efficiency (Banos et al, 2008); and the bGH releasing hormone associated with carcass traits (Cheong et al, 2006). From an interactive network, some of these candidate genes, although not directly related to a determined trait, can have an indirect physiological relationship leading to significant enhancement of a correlated response in another trait (Paredes-Sánchez et al, 2015).…”

Investigation of the promoter polymorphisms of the growth hormone (GH1), growth hormone receptor (GHR), insulin-like growth factor (IGF-I), and prolactin (PRL) genes and the correlation between gene expression and milk yields in Holstein cattle raised in Central Anatolia

“…In animal species with long generation intervals, including cattle, genetic research aimed at the improvement of yield traits using conventional selection methods can be challenging, costly, and time-consuming. However, the marker-assisted selection method, based on the use of conventional selection methods in combination with genetic markers known or considered to be associated with certain yield traits, overcomes these disadvantages (2).…”

Türkiye’deki Holştayn, İsviçre Esmeri ve Simmental Sığır Irklarında Kapa-Kazein, Büyüme Hormonu ve Prolaktin Genlerinin Allel Frekansları

“…The growth hormone is involved in multiple physiological processes, including the regulation of growth, development of the mammary glands, onset of lactation, glucogenesis, activation of lypolysis, and regulation of muscle development 6 . In view of the abovementioned effects of the growth hormone, both GH concentration and the allelic variations of the gene coding this hormone have drawn the attention of researchers.…”

“…In view of the abovementioned effects of the growth hormone, both GH concentration and the allelic variations of the gene coding this hormone have drawn the attention of researchers. It has been reported that, in cattle, the bGH gene is correlated with certain yield traits, in particular with milk yield and quality, growth 6 , carcass composition and quality 7 . In this context, it is considered that it could be of use as a candidate gene in animal improvement programmes targeted at increasing milk and meat yields 8 .…”

“…In this context, it is considered that it could be of use as a candidate gene in animal improvement programmes targeted at increasing milk and meat yields 8 . Previous molecular genetic studies have demonstrated that yield traits such as milk yield and body weight gain are correlated with certain polymorphisms of the bGH gene 6 .…”