Organic mental disorder after pneumococcal meningoencephalitis with autism-like symptoms

Baldaçara, Leonardo; Diniz, Thaynne Almeida; Parreira, Bruna Leal; Milhomem, Jaqueline Jerônimo; Baldaçara, Raquel Prudente de Carvalho

doi:10.1590/s1516-44462011000400016

Cited by 5 publications

(3 citation statements)

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“…88 Cases of autistic regression following viral and bacterial encephalitis have been reported in previously healthy and typically-developing children [90][91][92][93] as well as in adolescents and even adults. [94][95][96][97] Autistic regression has also been reported in cases following the onset of autoimmune proliferative syndrome, or autoimmune anti-N-methyl-D-aspartate receptor antibodies (NMDAR-Ab) encephalitis. [98][99][100] NMDAR-Ab encephalitis is a well-characterised clinicalimmunological syndrome caused by an autoimmune reaction to neuronal NMDA receptors.…”

Section: Autistic Regression and Its Association With Infection Automentioning

confidence: 99%

<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>

Sala¹,

Amet²,

Blagojevic-Stokic³

et al. 2020

NDT

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Autism spectrum disorder (ASD) is a highly complex and heterogeneous developmental disorder that affects how individuals communicate with other people and relate to the world around them. Research and clinical focus on the behavioural and cognitive manifestations of ASD, whilst important, have obscured the recognition that ASD is also commonly associated with a range of physical and mental health conditions. Many physical conditions appear with greater frequency in individuals with ASD compared to non-ASD populations. These can contribute to a worsening of social communication and behaviour, lower quality of life, higher morbidity and premature mortality. We highlight some of the key physical comorbidities affecting the immune and the gastrointestinal systems, metabolism and brain function in ASD. We discuss how healthcare professionals working with individuals with ASD and parents/carers have a duty to recognise their needs in order to improve their overall health and wellbeing, deliver equality in their healthcare experiences and reduce the likelihood of morbidity and early mortality associated with the condition.

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Section: Autistic Regression and Its Association With Infection Automentioning

confidence: 99%

<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>

Sala¹,

Amet²,

Blagojevic-Stokic³

et al. 2020

NDT

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“…Various causes of ASD have been identified including syndromic autism (10) (appearing as part of a known genetic condition), ASD accompanying inborn errors of metabolism (11,12) such as phenylketonuria (PKU) (13), ASD onset following prenatal exposure to specific medications such as sodium valproate (14) and following exposure to infectious diseases such as rubella (15). There have also been many reports of core symptoms and hallmarks of autism emerging as a consequence of viral (16) and bacterial encephalitis (17) in previously developmentally typical children and even adults. There are multiple examples of cases that demonstrate a link between infection and ASD, ranging from developmental and behavioural changes following herpes encephalitis (18,19) to HIV infection (20)(21)(22), where so-called "paediatric NeuroAIDS" patients develop all the core symptoms of ASD as well as numerous accompanying behaviours and presentations (23).…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Encephalitis and Autism Spectrum Disorder

Whiteley¹,

Marlow

Kapoor

et al. 2021

Front. Psychiatry

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The concept of “acquired autism” refers to the hypothesis that amongst the massive heterogeneity that encompasses autism spectrum disorder (ASD) there may be several phenotypes that are neither syndromic nor innate. Strong and consistent evidence has linked exposure to various pharmacological and infective agents with an elevated risk of a diagnosis of ASD including maternal valproate use, rubella and herpes encephalitis. Autoimmune encephalitis (AE) describes a group of conditions characterised by the body's immune system mounting an attack on healthy brain cells causing brain inflammation. The resultant cognitive, psychiatric and neurological symptoms that follow AE have also included ASD or autism-like traits and states. We review the current literature on AE and ASD. Drawing also on associated literature on autoimmune psychosis (AP) and preliminary evidence of a psychosis-linked subtype of ASD, we conclude that AE may either act as a potentially causative agent for ASD, and/or produce symptoms that could easily be mistaken for or misdiagnosed as autism. Further studies are required to discern the connection between AE and autism. Where autism is accompanied by regression and atypical onset patterns, it may be prudent to investigate whether a differential diagnosis of AE would be more appropriate.

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“…Baldaçara L. с соавт. описали случай развития расстройств аутистического спектра после перенесенного эпизода пневмококкового менингоэнцефалита [6]. Учитывая концепцию PANDAS, известное снижение резистентности к стрептококковой инфекции может объяснить некоторые случаи развития экстрапирамидных и обсессивно-компульсивных расстройств у детей с аутизмом [74].…”

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Основные Аспекты Иммунодиагностики И Иммунотерапии При Расстройствах Спектра Аутизма У Детей

Maltsev¹,

Chuprikov²,

Mishyyev³

et al. 2022

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Психіатрія, медична психологія/ Психиатрия, медицинская психология / Psychiatry, clinical psychology ________________________________________________________________________________________________ УДК 616.89:316.6]-053.2-092:612.017.1 ОСНОВНЫЕ АСПЕКТЫ ИММУНОДИАГНОСТИКИ И ИММУНОТЕРАПИИ ПРИ РАССТРОЙСТВАХ СПЕКТРА АУТИЗМА У ДЕТЕЙ Мальцев Д. В.¹, кандидат медицинских наук Чуприков А. П.², доктор медицинских наук, профессор Мишиев В. Д.², доктор медицинских наук, профессор Кириллова Л. Г.³, доктор медичних наук Коляденко Н. В. 4 , доктор медичних наук ¹Национальный медицинский университет имени А. А. Богомольца (Украина) ²Национальная медицинская академия последипломного образования имени П. Л. Шупика (Украина) ³ГУ «Институт педиатрии, акушерства и гинекологии НАМН Украины» (Украина) 4 Межрегиональная академия управления персоналом (Украина) Резюме: Данный обзор посвящен анализу доказательств участия иммунной системы в патогенезе расстройств спектра аутизма у детей. На сегодняшний день продемонстрирована связь аутизма с локусами гистосовместимости, первичными иммунодефицитами, признаками иммунной дизрегуляции, оппортунистическими и условнопатогенными инфекциями, аутоантителами к мозговым антигенам, гиперчувствительностью к пищевым аллергенам, канцерогенезом и плохим профилем переносимости вакцин. Установлена эффективность некоторых иммунотерапевтических и иммуномодулирующих подходов, включая элиминационную диету, в/в иммуноглобулин, препараты глюкортикостероидов и адренокортикотропного гормона, леналидомид, пиоглитазон, трансфер-фактор, пентоксифиллин, трансплантацию стволовых гемопоэтических клеток. Ключевые слова: расстройства спектра аутизма, иммунодефицит, аутоиммунитет, иммунотерапия.Резюме: Даний огляд присвячений аналізу доказів участі імунної системи в патогенезі розладів спектру аутизму у дітей. На сьогоднішній день продемонстрований зв'язок аутизму з локусами гістосумісності, первинними імунодефіцитами, ознаками імунної дизрегуляції, опортуністичними та умовно патогенними інфекціями, автоантитілами до мозкових антигенів, гіперчутливістю до харчових алергенів, канцерогенезом і поганим профілем переносимості вакцин. Встановлено ефективність деяких імунотерапевтичних та імуномодулюючих підходів, включаючи елімінаційну дієту, в/в імуноглобулін, препарати глюкортикостероідів і адренокортикотропного гормону, леналідомід, піоглітазон, трансфер-фактор, пентоксифілін, трансплантацію стовбурових гемопоетичних клітин. Ключові слова: розлади спектру аутизму, імунодефіцит, автоімунітет, імунотерапія. Summary: This review analyzes the evidence of immune system involvement in the pathogenesis of autism spectrum disorders in children. To date, demonstrated link autism with MHC loci, primary immune deficiencies, signs of immune dysregulation, opportunistic and streptococcal infections, autoantibodies to brain antigens, hypersensitivity to food allergens, carcinogenesis and poor tolerability profile of the vaccines. There was evaluated the effectiveness of some immunomodulatory and immunotherapeutic approaches, including the ...

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Organic mental disorder after pneumococcal meningoencephalitis with autism-like symptoms

Cited by 5 publications

References 5 publications

<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>

<p>Bridging the Gap Between Physical Health and Autism Spectrum Disorder</p>

Autoimmune Encephalitis and Autism Spectrum Disorder

Основные Аспекты Иммунодиагностики И Иммунотерапии При Расстройствах Спектра Аутизма У Детей

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