HLA-DRB1 alleles in four Amerindian populations from Argentina and Paraguay

Parolín, María Laura; Carnese, Francisco R.

doi:10.1590/s1415-47572009000200002

Cited by 13 publications

(18 citation statements)

References 27 publications

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“…The Wichí, as well as the native people of Gran Chaco region in general, have been previously analyzed for autosomal and Y chromosome repetitive polymorphisms (Tourret et al 1999(Tourret et al , 2000Demarchi and Mitchel 2004;Catanesi et al 2006;Crossetti et al 2008;Demarchi 2009;Parolin and Carnese 2009), and a marked reduction in genetic variability has been found. In the present study, we found a similar situation for repetitive markers in X chromosome, where the modal alleles showed frequencies over 40-70%, and some rare alleles had probably been lost.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variation of X-STRs in the Wichí Population from Chaco Province, Argentina

2013

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The Wichí people from Chaco Province inhabit the region called Impenetrable Chaqueño, where the climatic conditions are extreme. Besides scarce communication with the main urban centers, the cultural patterns of the Wichí cause these communities to live in certain degree of isolation. The effect of this situation is an increased genetic differentiation from other populations, as it was observed through autosomal and Y chromosome markers. However, the genetic variation of X chromosome has not yet been fully analyzed. The patterns of allele distribution of different markers of X chromosome can be highly informative in comparative studies, because its special features make this chromosome a potential source to uncover ethnic differences. The aim of this study was to assess the variation of X chromosome present in the Wichí population living around Misión Nueva Pompeya, in Chaco Province, and to identify particular variation of X-repetitive markers (short tandem repeats, X-STRs) in Chaco Amerindians. We genotyped Wichí for 10 noncoding X-STRs and compared them with a Mocoví population and with published data on individuals coming from European immigration. We found high homozygote proportion and linkage disequilibrium values for the X chromosome in the Wichí population. The data showed the Wichí to be more distant from nonnative people than was the Mocoví population analyzed for comparison. We also found certain differences with Mocoví, possibly due to a higher genetic flow of the latter with nonnatives. A process of genetic drift seems to be enhanced by the social behavior of the Wichí, since they live apart from other native and nonnative groups. The geographic isolation and the extreme environmental conditions can also be considered as major factors contributing to the population differentiation. Although we found no new allele or undescribed variation, the whole pattern of variation for these markers gives the Wichí a particular population identity.

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Section: Discussionmentioning

confidence: 99%

Genetic Variation of X-STRs in the Wichí Population from Chaco Province, Argentina

2013

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“…These alleles are extensively distributed throughout the Americas in indigenous populations of North, Central and South America (16) and Latin America. (17) Some detected allelic variants (DRB1*04:03, DRB1*04:05, DRB1*08:02 and DRB1*09:01) are widely distributed in Asians, in particular in individuals from Northeastern Asia, but also in Caucasians and African descendants.…”

Section: Discussionmentioning

confidence: 99%

HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana State

Bardi

Jarduli

Jorge

et al. 2011

Rev. Bras. Hematol. Hemoter.

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BackgroundKnowledge of allele and haplotype frequencies of the human leukocyte antigen (HLA) system is important in the search for unrelated bone marrow donors. The Brazilian population is very heterogeneous and the HLA system is highly informative of populations because of the high level of polymorphisms.AimThe aim of this study was to characterize the immunogenetic profile of ethnic groups (Caucasians, Afro-Brazilians and Asians) in the north of Parana State.MethodsA study was carried out of 3978 voluntary bone marrow donors registered in the Brazilian National Bone Marrow Donor Registry and typed for the HLA-A, B and DRB1 (low resolution) loci. The alleles were characterized by the polymerase chain reaction sequence-specific oligonucleotides method using the LabType SSO kit (One Lambda, CA, USA). The ARLEQUIN v.3.11 computer program was used to calculate allele and haplotype frequenciesResultsThe most common alleles found in Caucasians were HLA-A*02, 24, 01; HLA-B*35, 44, 51; DRB1*11, 13, 07; for Afro-Brazilians they were HLA-A*02, 03, 30; HLA-B*35, 15, 44; DRB1*13, 11, 03; and for Asians they were: HLA-A*24, 02, 26; HLA-B*40, 51, 52; DRB1*04, 15, 09. The most common haplotype combinations were: HLA-A*01, B*08, DRB1*03 and HLA-A*29, B*44, DRB1*07 for Caucasians; HLA-A*29, B*44, DRB1*07 and HLA-A*01, B*08 and DRB1*03 for Afro-Brazilians; and HLA-A*24, B*52, DRB1*15 and HLA-A*24, B*40 and DRB1*09 for Asians.ConclusionThere is a need to target and expand bone marrow donor campaigns in the north of Parana State. The data of this study may be used as a reference by the Instituto Nacional de Cancer/Brazilian National Bone Marrow Donor Registry to evaluate the immunogenetic profile of populations in specific regions and in the selection of bone marrow donors

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“…The highest frequency found was among the Chimila tribe (84.1%), followed by the Arsario, Kogui, Bari, Arhuaco and Tunebo, as well as in the Choco-Paezan speaking groups Embera and Waunana of the Chibcha family. This haplotype had also been found in Central America among the Mexican Amerindian tribes, Seri (44%), Mazatecan (28%), and Mixteco (29%) (Arnaiz-Villena et al , 2000; Salzano 2002), among the Cayapa Amerindian tribe of Ecuador (27%), the Wayuu tribe of Colombia (11.5%), the Guarani in Brazil (Tsuneto et al , 2003), and in the Mapuche and Tehuelche tribes of Argentina (Parolin and Carnese 2009). In contrast, it was present at very low frequencies among few Amerindian tribes of the Orinoquian and Amazonian region of Colombia (Guahibo 1.9%, Cubeo 0.8% and Puinave 0.4%).…”

Section: Discussionmentioning

confidence: 78%

“…Different studies of MHC class-I and class-II alleles in Amerindian populations have been carried out for anthropological as well as evolutionary studies (Layrisse et al , 1973; Kostyu and Amos 1981; Williams et al , 1981; Vullo et al , 1984; Gorodezky et al , 1985; Long et al , 1991; Petzl-Erler et al , 1993; Tsuneto et al , 2003; Parolin and Carnese 2009; Arnaiz-Villena et al , 2010, 2011; Vargas-Alarcon et al , 2011). New MHC class I and class II alleles have been identified in North and South Amerindian communities (Belich et al , 1992; Watkins et al , 1992; Zhang et al , 1993; Layrisse et al , 1997; Mack and Erlich 1998).…”

Section: Introductionmentioning

confidence: 99%

MHC Class II haplotypes of Colombian Amerindian tribes

Yunis

Yunis³

2013

Genet. Mol. Biol.

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We analyzed 1041 individuals belonging to 17 Amerindian tribes of Colombia, Chimila, Bari and Tunebo (Chibcha linguistic family), Embera, Waunana (Choco linguistic family), Puinave and Nukak (Maku-Puinave linguistic families), Cubeo, Guanano, Tucano, Desano and Piratapuyo (Tukano linguistic family), Guahibo and Guayabero (Guayabero Linguistic Family), Curripaco and Piapoco (Arawak linguistic family) and Yucpa (Karib linguistic family). for MHC class II haplotypes (HLA-DRB1, DQA1, DQB1). Approximately 90% of the MHC class II haplotypes found among these tribes are haplotypes frequently encountered in other Amerindian tribes. Nonetheless, striking differences were observed among Chibcha and non-Chibcha speaking tribes. The DRB1*04:04, DRB1*04:11, DRB1*09:01 carrying haplotypes were frequently found among non-Chibcha speaking tribes, while the DRB1*04:07 haplotype showed significant frequencies among Chibcha speaking tribes, and only marginal frequencies among non-Chibcha speaking tribes. Our results suggest that the differences in MHC class II haplotype frequency found among Chibcha and non-Chibcha speaking tribes could be due to genetic differentiation in Mesoamerica of the ancestral Amerindian population into Chibcha and non-Chibcha speaking populations before they entered into South America.

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HLA-DRB1 alleles in four Amerindian populations from Argentina and Paraguay

Cited by 13 publications

References 27 publications

Genetic Variation of X-STRs in the Wichí Population from Chaco Province, Argentina

Genetic Variation of X-STRs in the Wichí Population from Chaco Province, Argentina

HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana State

MHC Class II haplotypes of Colombian Amerindian tribes

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