Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model

Abstract

The growth hormone 1 gene (GH1) is a candidate gene for body weight and weight gain in cattle since it plays a fundamental role in growth regulation. We investigated the GH1 gene AluI and DdeI restriction enzyme polymorphisms, located 149 bp apart in the cattle genome, as possible markers of the production potential of Canchim crossbreed cattle, a 5/8 Charolais (Bos taurus) and 3/8 Nelore (Bos indicus) breed developed in Brazil, by evaluating the birth weight, weaning weight, yearling weight and plasma insulin-like growth factor-1 (IGF-1) concentration of 7 month to 10 months old Canchim calves (n = 204) of known genealogy and which had been genotyped for the AluI and DdeI markers. Our results showed significant effect (p < 0.05) between the homozygous DdeI+/DdeI+ polymorphism and the estimated breeding value for weaning weight (ESB-WW), while the AluI leucine homozygous (L/L) and leucine/valine (L/V) heterozygous polymorphisms showed no significant effect on the traits studied. The restriction sites of the two enzymes led to the formation of haplotypes which also exerted a significant effect (p < 0.05) on the ESB-WW, with the largest difference being 8.5 kg in favor of the homozygous L plus DdeI+/L plus DdeI+ genotype over the heterozygous L plus DdeI-/V plus DdeI+ genotype.

Short Communication: Identification of Growth Hormone gene polymorphism for beef cattle in Pesisir Selatan District, West Sumatra, Indonesia

“…The GH L allele was predominantly found in both of cattle populations This is same with previous studies in the Growth Hormone gene in cattle, Reis et al 2001;Silveira et al 2008;Mu'in et al 2007;Hartatik et al 2013;Volkandari et al 2013;Moravcikova et al 2012;Akcay et al 2015).…”

“…It means that migration or introduction of V allele has been happened in population. Chanchim cattle, is synthetic cattle with 5/8 Charolais (Bos taurus) and 3/8 Nelore (Bos indicus), have L allele frequency (0.99) (Silveira et al 2008).…”

Determination of the AluI polymorphism effect of bovine growth hormone gene on carcass traits in Zavot cattle with analysis of covariance

“…For example, a significant association was found between GH locus, weight gain, and body weight at slaughter in Zebu and Zebu crossbreeds, such as Canchim (19). Similarly, this association has been reported to be different in Bos taurus cattle breeds such as Simmental, Japan Black cattle, and Slovakian Pied cattle (11,(20)(21)(22)(23). In contrast, Di Stasio et al (24) reported no association between GH polymorphism, growth, and carcass traits.…”

Association of growth hormone (GH) gene polymorphism with growth and carcass in Sumba Ongole (SO) cattle

“…superovulation response, ovulation rate, fertility rate and embryo quality as reported by Sumantri et al (2011). The importance of the function of GH gene make this gene as one of candidate genes for Marker Assisted Selection program (Tambasco et al, 2003;Beauchemin et al, 2006;Silveira et al, 2008;Ribeca et al, 2014).…”