Síndrome de Sweet e policondrite recidivante reveladores de síndrome mielodisplásica

Diamantino, Filipa; Raimundo, Pedro Manuel Oliveira da Cunha; Fidalgo, Ana

doi:10.1590/s0365-05962011000700045

Cited by 11 publications

(7 citation statements)

References 11 publications

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“…Chronology in the diagnostics of SS related to myeloproliferative disorders can be difficult. In case 3 [ 1 ], dermatological recurrent episodes showed early leukopenia at first with a shift in complete blood count that occurred after 15 months in association with non-megaloblastic macrocytic anemia and neutropenia.…”

Section: Discussionmentioning

confidence: 99%

“…Sweet syndrome was first identified in 1964 by Robert Sweet as a febrile neutrophilic dermatosis with acute onset, with an unclear pathogenesis [ 1 ]. He described the cases of eight women with skin eruptions that resembled erythema multiforme, which is associated with leukocytosis, mainly neutrophil polymorphonuclears and fever.…”

Section: Introductionmentioning

confidence: 99%

“…It was initially classified into five groups: classic, parainflammatory, paraneoplastic, associated with pregnancy and secondary to drug administration [ 1 ], but it has been categorized by more recent articles into classical SS, malignancy-associated SS (MASS) and drug-induced SS (DI-SS) [ 5 ]. Drugs that have been classified as SS inducers are shown in Table 1 [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

Ferea

Mihai

Bălan

et al. 2023

Life

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Sweet syndrome (SS) is a rare disease described as a febrile neutrophilic dermatosis with acute onset, the pathogenesis of which has not yet been elucidated. The syndrome is characterized by the sudden onset of erythematous infiltrated papules or plaques located on the upper body and is associated with fever, leukocytosis and neutrophilia. The lesions show a dense dermal infiltration with mature neutrophils. The condition is responsive to systemic steroids. The central nervous system, bones, muscles, eyes, ears, mouth, heart, lung, liver, kidneys, intestines, and spleen may be affected by SS as extracutaneous manifestations. More and more cases have been found to be associated with malignancies, particularly myelodysplastic syndrome, and, less frequently, other hematologic malignancies or solid tumors. Approximately 21% of patients with SS have an associated malignancy and up to 80% of MASS cases are associated with hematological diseases, predominantly myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Myelodysplastic syndrome is a clonal disease of the bone marrow characterized by inefficient hematopoiesis, dysplasia of the bone marrow and peripheral cytopenias. Affected patients have a high risk of leukemic transformation. After analyzing later studies and current practical aspects regarding MDS-related SS, we suggest an algorithm for evaluating these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

Ferea

Mihai

Bălan

et al. 2023

Life

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“…Foram baseados nos achados clínicos, na histologia e nos exames laboratoriais. A doença é definida pela presença de dois critérios maiores -aparecimento abrupto de placas ou nódulos eritematosos e dolorosos e infiltração dérmica neutrofílica sem sinal de vasculite -e de pelos menos dois critérios menores dentre os seguintes: febre acima de 38ºC; infecção do trato respiratório ou do trato gastrointestinal anterior ao quadro ou associação com vacinação, doença inflamatória, neoplasias ou gestação; presença dos seguintes achados laboratoriais (três dos quatro): VHS acima de 20mm; proteína C reativa positiva; contagem de leucócitos acima de 8.000; mais de 70% de neutrófilos no hemograma e excelente resposta ao tratamento com corticoides ou iodeto de potássio [7][8][9] .…”

Section: Discussionunclassified

“…Diferente da idiopática, não tem predileção por sexo e as lesões cutâneas são mais graves, tendem a ser vesiculosas, bolhosas ou mesmo necróticas e ulcerativas. O envolvimento extracutâneo e a ausência de neutrofilia ocorrem em mais da metade dos casos, já as recorrências clinicas são mais frequentes e concomitantes com as recidivas tumorais 4,8,10 .…”

Section: Discussionunclassified

Síndrome De Sweet - Relato De Caso E Revisão De Como Investigar E Tratar

Timbó

Santos

Meotti

et al. 2013

SPDV

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Introdução: A sindrome de Sweet é uma dermatose neutrofílica que apresenta lesões cutâneas agudas na forma de placas e nódulos eritemato edematosos. Outras alterações como febre, leucocitose periférica, artralgia, mialgia, cefaléia, acometimento ocular, oral e de órgãos internos podem ocorrer. O objetivo deste trabalho é discu- tir o quadro clínico, critérios diagnósticos, abordagem investigativa e possíveis tratamentos para esta enfermidade. Caso Clínico: Paciente, sexo feminino, 45 anos, branca, com sindrome de Sweet idiopática tratada com glicocorti- cóides. Ao exame, apresentava placas eritematosas, edematosas com pseudovesiculação na face, tronco, membros superiores e inferiores. O exame histopatológico mostrou intenso edema, infiltrado de neutrófilos, leucocitoclasia e extravasamento de hemácias na derme superior. Discussão: A sindrome de Sweet pode estar relacionada ao uso de medicamentos, gestação, inflamações, infecções e malignidades. As neoplasias mais frequentemente associadas são as hematológicas, em especial a leucemia mielóide aguda. Apesar de os glicocorticóides serem tratamentos de elei- ção na sindrome de Sweet, existem outras alternativas terapêuticas. PALAVRAS-CHAVE – Síndrome de Sweet; Síndrome paraneoplásica; Dermatose neutrofílica.

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Relapsing Polychondritis: A Review and Guide for the Dermatologist

2016

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Relapsing polychondritis, or RP, is a rare connective tissue disease characterized by relapsing-remitting destructive inflammation of the cartilaginous and other proteoglycan-rich structures in the body. Given the relatively low incidence of RP, a concise clinically relevant guide, focusing on the cutaneous manifestations of this serious disease, is lacking. In this review, we provide the dermatologist with an approach to diagnosing RP and a guide to its initial work-up, and management. We close with an overview of the currently available treatment modalities for RP.

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Síndrome de Sweet e policondrite recidivante reveladores de síndrome mielodisplásica

Cited by 11 publications

References 11 publications

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

Síndrome De Sweet - Relato De Caso E Revisão De Como Investigar E Tratar

Relapsing Polychondritis: A Review and Guide for the Dermatologist

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