Porokeratosis ptychotropica is a rare variant of porokeratosis that is classically
located on the gluteal and perianal regions, seldom extending to the genitalia. The
authors report an atypical presentation of porokeratosis ptychotropica and discuss
the use of dermoscopy in evaluating this dermatosis. Dermoscopic findings, although
not specific to this variant of porokeratosis, are helpful in the differential
diagnosis of other genital disorders. Histopathology, through the visualization of
multiple cornoid lamellae, prevails as the gold standard for the definite diagnosis
of porokeratosis ptychotropica.
Certas dermatoses, pertencentes ao grupo das síndromes paraneoplásicas mucocutâneas, podem ser o prenúncio de uma neoplasia previamente não conhecida. Tanto a síndrome de Sweet como a policondrite recidivante incluem-se neste grupo. A síndrome de Sweet e a PR são raramente encontradas em um mesmo paciente. A presença de policondrite recidivante e síndrome de Sweet em um mesmo paciente tem se revelado mais frequente em pacientes com neoplasias associadas, sobretudo hematológicas. Relata-se o caso de paciente do sexo masculino, 79 anos, com síndrome de Sweet e policondrite recidivante, em quem, subsequentemente, foi diagnosticada uma síndrome mielodisplásica
Primary cutaneous follicle center lymphoma (PCFCL) is characterized by a proliferation of follicle center cells in the skin. A definitive diagnosis is frequently delayed because of difficulties in interpretation of the histopathologic findings. It has an excellent prognosis with a 5-year survival over 95% and its risk of transformation has not been established. We describe a case report of man with a gastric diffuse large B-cell lymphoma (DLBCL) referred to our clinic because of nodules in the back that had gradually developed over a period of 10 years. A biopsy performed 3 years before was interpreted as reactive follicular hyperplasia. A new skin biopsy revealed a diffuse large B-cell lymphoma and immunoglobulin heavy chain gene rearrangements from the initial skin biopsy (PCBCL) and the DLBCL gastric biopsy were studied by polymerase chain reaction and an identical clonal rearrangement was detected which was highly suggestive of a transformation lymphoma.
Letters to the Editor resistant rickets type IIA, a compound heterozygote for mutations in the Vitamin D receptor gene (VDR) in which the phenotype of atrichia with papular lesions was identical to that seen in patients carrying mutations in the HR gene. It is hypothesized that the VDR and HR genes, which are both zinc-finger proteins, may be in the same genetic pathway that controls postnatal cycling of the hair follicle. [4] Yip et al. [5] proposed revised clinical criteria for APL based on their personal observation and have made a retrospective analysis of cases described in literature. These features are listed in Table 1.Published estimates of the prevalence of APL remain surprisingly low, considering that pathogenetic mutations in HR have been found in distinct populations around the world. [2] APL is more common than previously thought and is often mistaken for the putative autoimmune form of alopecia universalis. [5]
ACKNOWLEDGMENTSWe would like to acknowledge the contributions of Dr. Priva
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