Tratamento sistêmico da psoríase - Parte I: metotrexato e acitretina

Martins, Gisele; Arruda, Lúcia Valéria Ramos de

doi:10.1590/s0365-05962004000300002

Cited by 17 publications

(16 citation statements)

References 31 publications

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“…1-3 The economic burden of psoriasis is also a matter of concern to patients due to the permanent cost of treatment and the possibility of lower productivity and absenteeism in the workplace. 4 Therefore, it is currently accepted that the evaluation of disease severity should include clinical, psychological and social factors. 5 …”

Section: Introductionmentioning

confidence: 99%

Psoriasis: correlation between severity index (PASI) and systemic treatment

Silva

Fortes

Miot

et al. 2013

An. Bras. Dermatol.

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BACKGROUND Psoriasis is a chronic inflammatory disease of the skin that affects patients of all ages andboth genders. The impact of the disease on quality of life is greater among patients with moderate to severe psoriasis. OBJECTIVE to establish a correlation between the psoriasis area and severity index (PASI) and theDermatology Life Quality Index (DLQI) based on a quality of life questionnaire adapted to the Brazilian contextfor patients with plaque psoriasis before and after systemic treatment. METHODSThis was a cross-sectional, descriptive study of psoriasis patients who did not undergo treatment or who manifested clinical activity of the disease. Patients were evaluated according to the PASI and the quality of life questionnaire adapted to theBrazilian context before and 60 days after systemic treatment. RESULTS Thirty-five patients participated in thestudy. Twenty-six were men, with a mean age of 46 years. There was no correlation between the PASI and thequality of life questionnaire adapted to the Brazilian context, but there was a correlation between the PASI andsome items of the quality of life questionnaire adapted to the Brazilian context, such as jobs involving public contact. CONCLUSIONThe non-correlation between the PASI and the quality of life questionnaire adapted to the Brazilian context in this work may be associated with a history of chronic disease, which implies greater acceptance of the illness, or may be related to the low income and social status of the patients studied. The correlationobserved among patients with careers involving public contact suggests that some professions are more impacted by the disease. It may be necessary to adapt the quality of life questionnaire to patients with a low income andcultural and social limitations. The small sample size (n=35 patients) and the short follow-up period of 60 dayswere some of the limitations of this work.

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Section: Introductionmentioning

confidence: 99%

Psoriasis: correlation between severity index (PASI) and systemic treatment

Silva

Fortes

Miot

et al. 2013

An. Bras. Dermatol.

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“…Our study we found that after methotrexate therapy patient's condition was improved. Martins and lucia (2004) in his study stated that MTX still represents a treatment option with good efficacy/cost/tolerance relationship, especially in poorer countries. The final decision of the therapeutic choice for patient with psoriasis should be based on their needs and preferences, but also on the clinical and economic consequences of the therapeutic strategy adopted, and some studies have confirmed a longer remission time and lower cost in rotating treatments with the use of MTX 10 .…”

Section: Methotrexate In Psoriasismentioning

confidence: 99%

Psoriatic Patient, Methotrexate Is a Good Choice of Drug

Shaha

Ara²,

Siddique³

et al. 2020

Med. Today

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Introduction: Psoriasis is a lifelong autoimmune disease which is characterized by white to red color patches of abnormalskin with patches of itchy and scaly. The term psoriasis derived from Greek word “psora” which means “itch”. It is achronic skin disease, touching about 2% of worldwide population. Different types of psoriasis have been reported such asplaque psoriasis, psoriatic arthritis, scalp psoriasis, flexural (inverse) psoriasis, guttate psoriasis, pustular psoriasis, nailpsoriasis, erythroderma which can be diagnosed by solid conclusion such as skin biopsies etc. Case report: We present thecase of a 55-years-old male with psoriasis. The diagnosis of psoriasis is based on the clinical features and history, as wellas on histopathological examinations of patient's tissue specimens. Any final diagnosis should include a differentialdiagnosis which includes severe seborrheic dermatitis, Contact dermatitis, pityriasisrubrapilaris and mycosis fungoideswhich can be clinically indistinguishable from a severe form of psoriasis. Histopathological studies are also generallyneeded to achieve a definitive diagnosis. After histopathological confirmation of psoriasis methotrexate therapy has beenstarted. Discussion: After comparing this case with several published articles/case reports on psoriasis we found somesimilarity regarding presentation, use and good response to methotrexate therapy but dissimilarity regarding response tosteroid therapy. Conclusion: Our patient showed an excellent response to methotrexate medication Medicine Today 2020 Vol.32(2): 145-147

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“…O ácido fólico (ácido diidrofólico) é ingerido na dieta e o ácido folínico (ácido tetraidrofólico) é usado, efetivamente, pelas vias metabólicas, sendo este o antído-to à superdosagem do metotrexato (Leucovorin cálci-co ® -10mg/m 2 de superfície corporal). 17 A administração de ácido fólico pode ser feita de 1-5mg/dia, sendo 1mg a dose indicada regularmente e 5mg/dia a indicada quando a dose de metotrexato é > 15mg/sem ou quando existem sinais de mielotoxicidade. Em crianças, administrar 1mg/dia em maiores de um ano e 50Ìg/kg/dia em menores de um ano.…”

Section: Metotrexatounclassified

Imunossupressores na Dermatologia

Bressan

Silva

Fontenelle³

et al. 2010

An. Bras. Dermatol.

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Resumo: Os imunossupressores são drogas que agem na divisão celular e têm propriedades anti-inflamatórias. Sendo assim, são essencialmente prescritos na prevenção de rejeição de transplantes e no tratamento das doenças autoimunes e inflamatórias crônicas, que, na Dermatologia, têm a psoríase como maior representante. Nesta sessão serão descritas as principais drogas imunossupressoras, com orientações para seu manejo adequado. Palavras-chave: Azatioprina; Ciclofosfamida; Ciclosporina; Imunossupressores; Metotrexato Abstract: Immunosupressants are drugs that act in cell division and have anti-inflammatory effects. Therefore, they are essentially prescribed in the prevention of transplant rejection and in the treatment of autoimmune disorders and chronic inflammatory diseases, whose main example in Dermatology is psoriasis. In this work the most important immunosuppressive drugs and orientation to properly administer them are going to be described. INTRODUÇÃOO tratamento imunossupressor é necessário para prevenir a rejeição de um órgão transplantado e também atua contra doenças inflamatórias, alvo principal da Dermatologia. Essa classe de drogas age inibindo a divisão celular, além de possuir propriedade antiinflamatória. Seu uso é indicado em psoríase, pênfigos e penfigoides, linfomas, entre outras patologias.Antes de iniciar uma terapia imunossupressora, é necessário conhecer as indicações, as contraindicações, os efeitos adversos e as interações medicamentosas, para poder minimizar os riscos do tratamento. Em alguns casos, ela pode ser prescrita para crianças, mas o calendário vacinal deve estar atualizado (vacinar 2-4 semanas antes do início do tratamento) e é preciso evitar vacina de vírus vivo durante este. 1 Além disso, algumas condutas deverão ser seguidas, como: anamnese (levando-se em conta a idade, os fármacos em uso e as comorbidades); realização de profilaxia para estrongiloidíase e esclarecimento ao paciente sobre a nova terapia. A rotina de exames pré-tratamento determinará, com a clínica, o medicamento mais indicado e sua respectiva dose.O objetivo de qualquer terapia médica é proporcionar cura e/ou alívio de doenças com o menor dano possível ao paciente. Isso está sendo alcançado graças ao vasto arsenal de drogas e agentes biológicos que tem possibilitado terapias imunossupressoras mais adaptadas às necessidades individuais dos pacientes. São as seguintes as premissas da individualização da imunossupressão: diferenças nos níveis de

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Tratamento sistêmico da psoríase - Parte I: metotrexato e acitretina

Cited by 17 publications

References 31 publications

Psoriasis: correlation between severity index (PASI) and systemic treatment

Psoriasis: correlation between severity index (PASI) and systemic treatment

Psoriatic Patient, Methotrexate Is a Good Choice of Drug

Imunossupressores na Dermatologia

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