Determination of acetylsalicylic acid in tablets with salicylate ion selective electrode in a Batch Injection Analysis system

Fernandes, Julio Cesar B.; Garcia, Carlos Alexandre Borges; Grandin, Luciane Aparecida; Neto, Graciliano de Oliveira; Godinho, Oswaldo E. S.

doi:10.1590/s0103-50531998000300008

Cited by 9 publications

(11 citation statements)

References 10 publications

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“…Addition-recovery tests were satisfactory, with values similar to those obtained using an official method of the British Pharmacopoeia 6 and to the label values. In addition, the reported results demonstrate that the combination of SWV with a BDD electrode is a feasible alternative for the analytical determination of ASA in commercial adult and children tablets without previous hydrolysis of the analyte as required by other methods 6,7,10,11,[15][16][17][18][19][20] or the necessity of expensive apparatus along with time-consuming sample preparations. 13,14 …”

Section: Discussionmentioning

confidence: 99%

“…This electrode showed a linear response to ASA in the concentration range 4.0 × 10 -3 mol L -1 to 4.0 × 10 -2 mol L -1 , with an analytical frequency of 28 samples h -1 . Fernandes et al 17 used a batch injection analysis (BIA) system for the potentiometric ASA determination in tablets, with a salicylate ion selective electrode. This system showed a linear response to ASA in the concentration range 7.5 × 10 -3 mol L -1 to 7.5 × 10 -2 mol L -1 , with an analytical frequency of 90 samples h -1 .…”

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confidence: 99%

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Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step

Sartori¹,

Medeiros²,

Rocha‐Filho³

et al. 2009

J. Braz. Chem. Soc.

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Neste trabalho descreve-se a determinação do ácido acetilsalicílico (ASA) em formulações farmacêuticas empregando voltametria de onda quadrada (SWV) e um eletrodo de diamante dopado com boro (BDD). Neste método, ASA é determinado diretamente em solução de H 2 SO 4 0,01 mol L -1 , sem a necessidade da hidrólise alcalina. Foi obtido um único pico de oxidação no potencial de 1,97 V vs. Ag/AgCl (KCl 3,0 mol L -1 ) com características de uma reação irreversível. A curva analítica obtida é linear na faixa de concentração ASA de 2,50 × 10 -6 -1,05 × 10 -4 mol L -1 , com um limite de detecção de 2,0 µmol L -1 . O desvio padrão relativo foi menor que 1,4% para uma solução de ASA 45 µmol L -1 (n = 10). O método proposto foi aplicado com sucesso para a determinação de ASA em várias formulações farmacêuticas e os resultados obtidos foram concordantes com um método oficial da Farmacopéia Britânica, a um nível de confiança de 95%.In this paper the determination of acetylsalicylic acid (ASA) in pharmaceutical formulations using square-wave voltammetry (SWV) and a boron-doped diamond electrode (BDD) is described. By this proposed method, ASA is directly determined in a 0.01 mol L -1 H 2 SO 4 solution without the need of a previous time-consuming alkaline hydrolysis step. A single oxidation peak at a potential of 1.97 V vs. Ag/AgCl (3.0 mol L -1 KCl) with the characteristics of an irreversible reaction was obtained. The obtained analytical curve is linear in the ASA concentration range 2.50 × 10 -6 -1.05 × 10 -4 mol L -1 , with a detection limit of 2.0 µmol L -1 . The obtained relative standard deviation was smaller than 1.4% for a 45 µmol L -1 ASA solution (n = 10). The proposed method was applied with success in the determination of ASA in several pharmaceutical formulations; the obtained results were in close agreement, at a 95% confidence level, with those obtained using an official method of the British Pharmacopoeia.Keywords: acetylsalicylic acid determination, boron-doped diamond electrode, square-wave voltammetry, pharmaceutical formulations IntroductionAcetylsalicylic acid (ASA), shown in Figure 1, more popularly known as aspirin, is one of the oldest medicines that still plays an important role in modern therapeutics. It is widely employed in pharmaceutical formulations for the relief of headaches, fever, muscular pain, and inflammation due to arthritis or injury. It was first synthesized in 1897, by Felix Hoffmann, in the Farbenfabrik Freidrich Bayer laboratories, in Elberfeld, Germany. 1,2 The high consumption of this substance all over the world 3,4 indicates the importance of the development of new analytical methods to assess not only the quality but also the authenticity of the product.The rate of decomposition of ASA to salicylic acid (SA) and acetic acid (AA) is dependent on solution pH and temperature. In the pH range 11-12 ASA is quickly hydrolyzed, in the pH range 4-8 its hydrolysis rate is slow, and maximum stability is attained at pH 2-3. 5 Commonly, ASA is indirectly determined after its conversion to SA ...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step

Sartori¹,

Medeiros²,

Rocha‐Filho³

et al. 2009

J. Braz. Chem. Soc.

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“…A multichannel pipette was utilized for the simultaneous injection of the sample over all the sensors [48]. Selective electrodes were explored for the quantification of salicylate in acetylsalicylic acid in tablets [49] and for mercury quantification [50].…”

Section: Potentiometrymentioning

confidence: 99%

Batch Injection Analysis: An Almost Unexplored Powerful Tool

2004

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The main purpose of this review is to report the development and potentialities of batch injection analysis (BIA) and call the attention of researchers about the power of this (until now) almost unexplored tool. The text focuses on the concepts and potentialities of BIA combined with other techniques for analytical purposes. The association of BIA with amperometry, potentiometry, voltammetry, calorimetry, fluorescence and spectrophotometry is presented and important aspects related with each technique are discussed. Some aspects comparing the similarities and differences between BIA, FIA and wall-jet are presented along the text.

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“…Applications utilizing potentiometry [3], spectrophotometry [4], fluorimetry [5], thermometry [6] and amperometry [7 ±9] were done in combination with BIA. Voltammetry was most frequently chosen and the potentialities of BIA associated with this technique were well-discussed [8].…”

Section: Introductionmentioning

confidence: 99%

Batch Injection Analysis Utilizing Modified Electrodes with Tetraruthenated Porphyrin Films for Acetaminophen Quantification

et al. 2002

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Batch injection analysis (BIA) utilizing amperometric detection with glassy carbon electrodes modified with [Co(TPyP){Ru(bipy) 2 Cl} 4 ](TFMS) 5 ¥ H 2 O porphyrin films were explored for acetaminophen analysis in pharmaceutical formulations. BIA is an interesting alternative for application of electrodes modified with tetraruthenated porphyrins. This sensor exhibited sharp current response peaks, rapid washout and excellent reproducibility for BIAamperometric quantification of acetaminophen. Also, a wide linear working range (10 À4 to 10 À6 mol L À1 ) as well as high sensitivity and sampling frequency rate (detection limit 1.1 Â 10 À7 mol L À1 , sampling frequency 120 injections/ h) and a small volume of analysis (100 mL/injection) was achieved. Furthermore, the proposed method permits the direct quantification of acetaminophen in many pharmaceutical products, avoiding cumbersome processes as previous separations, solvent extraction or sample filtration. The new procedure was applied to the analysis of commercial pharmaceutical products and the results were in excellent agreement with the ones obtained by spectrophotometric method. Accordingly, this amperometric method showed to be very well suited for quality control analysis and other applications with similar requirements.

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Determination of acetylsalicylic acid in tablets with salicylate ion selective electrode in a Batch Injection Analysis system

Cited by 9 publications

References 10 publications

Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step

Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step

Batch Injection Analysis: An Almost Unexplored Powerful Tool

Batch Injection Analysis Utilizing Modified Electrodes with Tetraruthenated Porphyrin Films for Acetaminophen Quantification

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