Experimental model of cutaneous radiation injury in rabbits

Meirelles, Rafael; Hochman, Bernardo; Helene, Américo; Lellis, Rute; Fraga, Murillo Francisco Pires; Ferreira, Lydia Masako

doi:10.1590/s0102-86502013001100001

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…In this context, many in vivo models such as mouse and rabbit have been investigated to establish a therapeutic strategy [18]. The disadvantages of these models are mainly the different skin structure and the excessive doses of radiation needed to observe the development of CRS [19,20]. Pig seems to be the most relevant animal model to develop and study the effects of cell therapy on CRS and other skin diseases.…”

Section: Introductionmentioning

confidence: 99%

Advances in Stem Cell Therapy: Specific Applications in the Treatment of Cutaneous Radiation Syndrome

Riccobono¹,

François²

2014

J Stem Cell Res Ther

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The emergence of stem cell therapy and cellular engineering during the last 10 years has allowed new therapeutic strategies to be considered for the treatment of many wound repair disorders in bones, muscles and skin. The cutaneous radiation syndrome that is often associated with radiation burn may also take advantage of these scientific advances. This syndrome, characterized by inflammatory waves, incomplete wound healing and poor revascularization is the dramatic consequence of local irradiation exposure (above 15Gy). Until the late 90's, the treatment schedule which exhibited poor efficacy consisted in excision followed by transient coverage of the wound bed and then by autologous skin grafts. Recently the local injection of autologous bone marrow mesenchymal stem cells, which favor wound healing and reduce pain, has achieved a major advance. However this strategy hampered by culture delays and requiring non-irradiated areas to harvest stem cells remains to be optimized. Autologous or allogeneic adipose tissue-derived stem cells, easy to collect and expand, may represent a valuable therapeutic alternative especially through pro-angiogenic and anti-inflammatory properties. Other proposed strategies including stem cell manipulation to produce trophic factors (transient gene therapy), bone marrow mesenchymal stem cells or adipose tissue derived stem cells culture media injection appear as valuable alternatives. In this review we report the latest scientific progresses in pre-clinical and clinical studies concerning stem cell therapy for cutaneous radiation syndrome.

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Section: Introductionmentioning

confidence: 99%