Efeito do óleo de copaíba nos níveis séricos de uréia e creatinina em ratos submetidos à síndrome de isquemia e reperfusão renal

Brito, Marcus Vinicius Henriques; Moreira, Raphael de Jesus; Tavares, Marcelo Luiz Couto; Carballo, Mariela Carolina Santos; Carneiro, Thiago Xavier; Santos, Alex de Assis Santos dos

doi:10.1590/s0102-86502005000300009

Cited by 18 publications

(7 citation statements)

References 5 publications

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“…In a similar study, Brito et al . [ 38 ] evaluated the effect of the oleoresin of C. multijuga on urea and creatinine serum levels in rats submitted to ischemia and reperfusion kidney. They observed a decrease in vascular permeability to proinflammatory agents caused by copaiba oleoresin, when in turn, decreased the migration of toxic agents to the renal parenchyma, thereby mitigating the damage of this organ.…”

Section: Biological Studies With Crude Copaiba Oleoresinsmentioning

confidence: 99%

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

et al. 2012

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Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.

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Section: Biological Studies With Crude Copaiba Oleoresinsmentioning

confidence: 99%

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

et al. 2012

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“…Several substances have been tested as alternatives to reduce deleterious effects of ischemia/reperfusion syndrome, such as chlorpromazine, verapamil, allopurinol, octreotide, copaiba oil, vitamins (C, D and E) and cyclosporin A. However, the effect of most them was disappointing [1][2][3][4] .…”

Section: ■ Introductionmentioning

confidence: 99%

Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats

Brito

Yasojima

Percário³

et al. 2017

Acta Cir. Bras.

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“…The pharmacological use of Copaifera spp. oleoresin as a homeopathic anti-inflammatory, antitumoral, and antibiotic agent is widespread [ 1 , 7 , 8 ]. The main compounds present in Copaifera spp.…”

Section: Introductionmentioning

confidence: 99%

Biological Activities and Cytotoxicity of Diterpenes from Copaifera spp. Oleoresins

et al. 2015

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Copaifera spp. are Amazonian species widely studied and whose oleoresins are used by local people for various medicinal purposes. However, a detailed study of the activity of the main phytochemical components of these oleoresins remains to be done. Here, we studied the cytotoxicity and in vitro anti-inflammatory effects of six diterpene acids: copalic, 3-hydroxy-copalic, 3-acetoxy-copalic, hardwickiic, kolavic-15-metyl ester, and kaurenoic, isolated from the oleoresins of Copaifera spp. The diterpenes did not show cytotoxicity in normal cell lines, nor did they show significant changes in viability of tumoral line cells. The 3-hydroxy-copalic was able to inhibit the enzyme tyrosinase (64% ± 1.5%) at 250 µM. The kolavic-15-metyl ester at 200 µM showed high inhibitory effect on lipoxygenase (89.5% ± 1.2%). Among the diterpenes tested, only kaurenoic and copalic acids showed significant hemolytic activities with 61.7% and 38.4% at 100 µM, respectively. In addition, it was observed that only the copalic acid (98.5% ± 1.3%) and hardwickiic acid (92.7% ± 4.9%) at 100 mM inhibited nitric oxide production in macrophages activated by lipopolysaccharide. In this assay, the diterpenes did not inhibit tumor necrosis factor-α production. The acids inhibited the production of IL-6, 3-acetoxy-copalic (23.8% ± 8.2%), kaurenoic (11.2% ± 5.7%), kolavic-15-methyl ester (17.3% ± 4.2%), and copalic (4.2% ± 1.8%), respectively, at 25 µM. The kaurenoic, 3-acetoxy-copalic and copalic acids increased IL-10 production. This study may provide a basis for future studies on the therapeutic role of diterpenic acids in treating acute injuries such as inflammation or skin disorders.

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Efeito do óleo de copaíba nos níveis séricos de uréia e creatinina em ratos submetidos à síndrome de isquemia e reperfusão renal

Abstract: The copaiba oil decreased significantly the urea serum level at 24 and 48 hours and the creatinine level at 48 hours after kidney ischemia and reperfusion in rats.

Cited by 18 publications

References 5 publications

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

Chemistry and Biological Activities of Terpenoids from Copaiba (Copaifera spp.) Oleoresins

Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats

Biological Activities and Cytotoxicity of Diterpenes from Copaifera spp. Oleoresins

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