Evaluation of antinociceptive and anti-inflammatory activities of extract and fractions of Eugenia jambolana root bark and isolation of phytoconstituents

Saha, Santanu; Subrahmanyam, E. V. S.; Kodangala, Chandrashekar; Mandal, Subhash C.; Shastry, C. S.

doi:10.1590/s0102-695x2013005000055

Cited by 20 publications

(16 citation statements)

References 32 publications

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“…They are known for their tasty fruits, and include some Brazilian plants as Eugenia uniflora ("Pitanga"), Eugenia involucrata ("Cereja-domato"), Eugenia jambolona ("jambolão") and Eugenia edulis ("jaboticaba"). This genus comprises a large group of medicinal plants with therapeutic applications of their different medicinal properties, such as anti-inflammatory, hypoglycemic, diuretic, analgesic, antidiarrheal, antirheumatic, antibacterial, protection against stomach disorders, etc (Saha et al, 2002;Auricchio and Bacchi, 2003;Bag et al, 2012;Victoria et al, 2012;Famuyiwa and Adebajo, 2012;Garmus et al, 2014). Infections caused by numerous microorganisms are a constant public health problem, and bacterial infections are responsible for several diseases such as pneumonia, meningitis, and endocarditis (Souza et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Tenfen¹,

Boeder²,

Bella-Cruz³

et al. 2017

J. Med. Plants Res.

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The aim of this study was to evaluate the chemical composition and antimicrobial activity of four unexplored Eugenia species: Eugenia brevistyla, Eugenia handroana, Eugenia catharinae and Eugenia stigmatosa. Eight extracts and eighteen fractions were screened for their antibacterial activity against some selected bacteria including Mycoplasma. Phytochemical screening revealed that the plants were rich in terpenes and phenolic compounds. Antimicrobial evaluation revealed that E. handroana (FAEF-EH) and E. brevistyla (FAEF-EB) had the highest activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) of 15.62 µg/ml Mycoplasma while FAEF-EH also presented the best activity with MIC of 62.5 µg/ml against Mycoplasma pneumonia M129. Some isolated compounds, betulinic acid and glutinol, also exhibited antibacterial property against some bacteria used in the study. All the four species studied presented promising antibacterial activity while the active principles are yet to be elucidated.

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Section: Introductionmentioning

confidence: 99%

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Tenfen¹,

Boeder²,

Bella-Cruz³

et al. 2017

J. Med. Plants Res.

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“…On the 8 th day, all the animals were sacrificed and the implanted cotton pellets were recovered, cleaned of surrounding tissues, and blotted with filter paper. These cleaned pellets were weighed and dried in a hot air oven overnight at 70°C and the dry weights were noted [16].…”

Section: Pharmacological Activitymentioning

confidence: 99%

Anti-inflammatory and Anti-arthritis Activity of Flavonoids Fractions Isolated from Centipeda minima Leaves Extracts in Rats

Sarkar¹,

Tripathi²,

Sahu³

2017

Clin Exp Pharmacol

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Centipeda minima has been used since centuries as a traditional medicinal plant in treating a number of disease conditions, the bioactive components responsible for its anti-inflammatory and anti-arthritis activity have not been identified. The present study was planned to isolate flavonoids fractions from Centipeda minima leaves extracts, and assessed anti-inflammatory and anti-arthritis activity in rats. The hydroalcoholic and aqueous extracts of Centipeda minima leaves were prepared and evaluated for in vitro antioxidant activity namely DPPH, total polyphenol content, total flavonol content and reducing power assay. The different fractions were isolated from hydroalcoholic extracts by using column chromatography. The Flavonoids fractions were investigated for anti-inflammatory and anti-arthritis activity in carrageenan rat induced paw oedema, cotton pellet-induced granuloma model and adjuvant induced chronic arthritis in rats. The findings of in vitro antioxidant activity confirmed that hydroalcoholic extracts expressed higher antioxidant activity compared to aqueous extract, and hence hydroalcoholic extracts was further selected for the isolation of various fractions. The results of phytochemical study suggest that FCM6, FCM7 and FCM8 exposed the presence of polyphenol and flavonoids. The fraction FCM6, FCM7 and FCM8 (25 mg/kg) exhibits significant antiinflammatory and anti-arthritis activity. The outcomes suggest that the anti-inflammatory and anti-arthritis activity of isolated fraction was due to presence of flavonoids and polyphenols.

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Section: Effect Of Isolated Compound Of Bauhinia Purpurea On Cotton Pmentioning

confidence: 99%

Evaluation of Anti-inflammatory and Anti-arthritis Activity of Isolated Fractions from Bauhinia purpurea Leaves Extracts in Rats

Sarkar¹,

Tripathi²,

Sahu

et al. 2017

PBJ

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Bauhinia purpurea are used as antinociceptive, antidiarrhoeal, anti-inflammatory, antiarthritis, analgesic, anticancer, antipyretic, anti-diabetics, anti-diarrheal activity etc. The flavonoids and polyphenol are present in Bauhinia purpurea and may play an important role in the treatment of inflammation and arthritis. Till date no one has documented about active constituents responsible for the anti-inflammatory and anti-arthritis activity. The present study was aimed to isolate fractions from Bauhinia purpurea leaves extracts, and assessed their anti-inflammatory and anti-arthritis activity in rats. The hydroalcoholic and aqueous extracts of Bauhinia purpurea leaves were prepared and tested for in vitro antioxidant activity namely DPPH, total polyphenol content, total flavonol content and reducing power assay. The antioxidant activity was performed only for proper selection of extracts, to isolate the polyphenol and flavonoids fractions from extract expressing maximum antioxidant activity.The different fractions were isolated from hydroalcoholic extracts by using column chromatography. The fractions FBP5, FBP8, FBP9 and FBP10 were further investigated for phytochemical screening to determine the nature of isolated compound. The fractions FBP8, FBP9 and FBP10 were screened for anti-inflammatory and anti-arthritis activity in carrageenan rat induced paw oedema, cotton pellet-induced granuloma model and adjuvant induced chronic arthritis in rats. The findings of in vitro antioxidant activity demonstrated that hydroalcoholic extracts expressed higher antioxidant activity compared to aqueous extract, and hence hydroalcoholic extracts was further selected for the isolation of various fractions.The results of phytochemical study imply that FBP8, FBP9 and FBP10 revealed the presence of polyphenol and flavonoids. The fraction FBP8, FBP9 and FBP10 (25 mg/kg) exhibits significant anti-inflammatory and anti-arthritis activity. The FBP9 produces maximum antiinflammatory and anti-arthritis activity compared to other fractions. These findings suggest that the anti-inflammatory and anti-arthritis activity of isolated fraction was due to presence of flavonoids and polyphenols.

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Evaluation of antinociceptive and anti-inflammatory activities of extract and fractions of Eugenia jambolana root bark and isolation of phytoconstituents

Cited by 20 publications

References 32 publications

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Anti-inflammatory and Anti-arthritis Activity of Flavonoids Fractions Isolated from Centipeda minima Leaves Extracts in Rats

Evaluation of Anti-inflammatory and Anti-arthritis Activity of Isolated Fractions from Bauhinia purpurea Leaves Extracts in Rats

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