Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Tenfen, Adrielli; Boeder, Ariela Maína; Bella-Cruz, Catarina C.; Bella-Cruz, Alexandre; CÃ3rdova, Caio M. M.; Cechinel‐Filho, Valdir

doi:10.5897/jmpr2017.6468

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…It corresponded to the presence of a carboxyl carbon signal at d 180.5, instead of an oxygenated methylene carbon signal at d 60.7 (C-28) as in 2. Thus, compound 3 was betulinic acid whose NMR data were in good compatibility with those in the literature5 . The 1 H NMR spectrum of compound 4 displayed one olefinic proton signal at d 5.29 (t, 3.5 Hz, H-12), together with a signal at d 2.83 (dd, 13.5, 4.0 Hz, H-18) which indicated the oleanan-12-ene skeleton.…”

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confidence: 74%

In vitro α-glucosidase inhibitory activity of compounds isolated from mangrove Lumnitzera littorea leaves

et al. 2019

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Introduction: Lumnitzera littorea grown at CanGio Mangrove Forest has been investigated. The present study reports the isolation, characterization and evaluation of the alpha-glucosidase inhibitory activity of isolated compounds from Lumnitzera littorea leaves. Methods: Their structures were elucidated by spectroscopic methods (including MS, 1D and 2D–NMR) and comparison with values from the literature. From the n-hexane extract, nine compounds including lupeol (1), betulin (2), betulinic acid (3), oleanolic acid (4), corosolic acid (5), -sitosterol (6), beta-sitosterol 3-O- beta-D-glucopyranoside (7), stigmast-5-ene-3beta-O-(6-O-hexadecanoyl-beta-D-glucopyranoside) (8), and stigmast-4-ene-3-one (9) were isolated and identified. Results: The results of the alpha-glucosidase inhibitory activity showed thatcorosolic acid (5) and oleanolic acid (4) were the most potent, with IC50 values of 17.86 +/- 0.42 and 18.82 +/- 0.59 ug/mL, respectively. Five of the other seven compounds exhibited inhibitory activity with IC50 values below 100 ug/mL, and higher than the positive control acarbose (127.64 +/- 0.64 ug/mL).

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confidence: 74%

In vitro α-glucosidase inhibitory activity of compounds isolated from mangrove Lumnitzera littorea leaves

et al. 2019

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“…aureus. In addition to the aforementioned secondary metabolites, there exists a reservoir of antimicrobial secondary metabolites present in the latex, including but not restricted to 1,6-anhydro-β- d -glucopyranose, hexadecanoic acid methyl ester, lupeol, lupeol acetate, and glutinol, which have also been documented to exhibit antimicrobial properties, as outlined in Table . − …”

Section: Discussionmentioning

confidence: 99%

Characterization, Antioxidant, and Antimicrobial Properties of Mulberry Lattices

Kumar R,

Gosipatala,

Kumar

et al. 2023

ACS Omega

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In order to find the most advantageous bioactive compounds from mulberry latex for drug development in the near future, this study was conducted to characterize and evaluate antioxidant and antimicrobial properties from four different mulberry lattices (BR-2, S-1, AR-14, and S-146). The characterization of the lattices was performed by scanning electron microscopy with energy-dispersive X-ray spectroscopy, gas chromatography coupled to mass spectroscopy, and Fourier transform infrared spectroscopy. Further, screenings of the antioxidant and antimicrobial potential of selected lattices were performed in vitro using 2,2-diphenyl-1-picrylhydrazyl assay and agar well diffusion methods, respectively. Interestingly, the outcome of the current study revealed that tested mulberry lattices contain a considerable amount of bioactive phytoconstituents, particularly antimicrobial and antioxidant compounds, as revealed by chromatographic analysis. BR-2 latex was found to have significant antioxidant activity (75%) followed by S-146 (64.6%) and AR-14 (52.9%). The maximum antimicrobial activity was found in BR-2 latex compared to other tested latex varieties. The results of this investigation showed that mulberry latex from the BR-2 type may successfully control both bacterial and fungal infections, with the added benefit of having enhanced antioxidant capabilities.

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“…The OD 600 values for the bacterial solutions with different concentrations of compounds were measured at the maximum absorption wavelength of the bacteria and then, the MIC was determined from the concentration curve versus OD 600 . The assays were carried out in triplicate and the results are expressed as the mean values ± standard deviations (Klančnik, Piskernik, Jeršek, & Možina, ; Muraina, Picard, & Eloffc, ; Tenfen et al, ).…”

Section: Methodsmentioning

confidence: 99%

Synthesis of amide derivatives containing capsaicin and their antioxidant and antibacterial activities

Wang

et al. 2019

J Food Biochem

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The capsaicin in hot peppers is an important biological active substance that is widely used in food and medicine. In this work, six capsaicin derivatives such as N‐(4‐Hydroxy‐3‐acetophenone benzyl)acrylamide (A), 2‐hydroxy‐3‐(octyloxy)phenyl‐5‐acrylamidemethylbenzene phenyl methanone (B), N‐(2,5‐dihydroxybenzene)acetamide (C), N‐(5‐acetamidemethyl benzene‐2,4‐dihydroxybenzene)acetamide (D), 4‐acetamideme thylbenzene‐2‐benzylphenol (E), and N‐(2‐methyl‐4‐hydroxy‐5‐methylthiobenzene)acetamide (F) were synthesized via the Friedel–Crafts (F–C) alkylation reaction and were characterized using IR, 1H NMR, and HRMS. The antioxidant activity of compounds was evaluated using the reducing power and DPPH radical (DPPH·) scavenging assays, and Vitamin C (Vc) was used as a control. The antibacterial activity was tested using minimum inhibition concentration (MIC) and antibacterial rate assays, and Escherichia coli and Staphylococcus aureus were used as the tested strain. The results showed that all six capsaicin derivatives had certain antioxidant and antibacterial activities, and the activities increased with increasing mass concentration. The best properties were obtained for compounds C and F; the antioxidant activity of compound C was similar to Vc and the MIC of compound F was 0.0313 mg/ml, its antibacterial rate was greater than 99% at 3 mg/ml. Practical applications As a vegetable, peppers can be eaten fresh or processed to other forms such as pepper powder or pepper jam, and it is very popular because of its long history, unique flavor, and special functions. Our current study shows that capsaicin derivatives have good antioxidant and antibacterial activities, and therefore, the present study of capsaicin derivatives with good activity provides a good foundation for future applications in natural food additives and medicine.

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Chemical composition, antibacterial and antimycoplasma activities of four Eugenia species growing in Brazil

Cited by 7 publications

References 28 publications

In vitro α-glucosidase inhibitory activity of compounds isolated from mangrove Lumnitzera littorea leaves

In vitro α-glucosidase inhibitory activity of compounds isolated from mangrove Lumnitzera littorea leaves

Characterization, Antioxidant, and Antimicrobial Properties of Mulberry Lattices

Synthesis of amide derivatives containing capsaicin and their antioxidant and antibacterial activities

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