Preparation and characterization of solid oral dosage forms containing soy isoflavones

Oliveira, Stela Ramirez de; Taveira, Stephânia Fleury; Marreto, Ricardo Neves; Valadares, Marize Campos; Diniz, Danielle Guimarães Almeida; Lima, Eliana Martins

doi:10.1590/s0102-695x2013005000007

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…Compact formulations of tablet based genistein and diadzein have been developed with various disintegrating substances to determine their specificity. Several studies have shown that the formulation of soy extracts prepared by direct compression method containing genistein and daidzein (50% w/w) increased cohesiveness and flow rates of oral tablets [ 79 ]. Polymeric micelles have been employed in pharmaceuticals, drug delivery and gene delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

et al. 2021

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Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better understanding of complex molecular interactions responsible for the multifaceted nature of cancer. Recent advances in the field of next generation sequencing and functional genomics have brought us closer towards unravelling the complexities of tumor microenvironment (tumor heterogeneity) and deregulated signaling cascades responsible for proliferation and survival of tumor cells. Phytochemicals have begun to emerge as potent beneficial substances aimed to target deregulated signaling pathways. Isoflavonoid genistein is an essential phytochemical involved in regulation of key biological processes including those in different types of cancer. Emerging preclinical evidence have shown its anti-cancer, anti-inflammatory and anti-oxidant properties. Testing of this substance is in various phases of clinical trials. Comprehensive preclinical and clinical trials data is providing insight on genistein as a modulator of various signaling pathways both at transcription and translation levels. In this review we have explained the mechanistic regulation of several key cellular pathways by genistein. We have also addressed in detail various microRNAs regulated by genistein in different types of cancer. Moreover, application of nano-formulations to increase the efficiency of genistein is also discussed. Understanding the pleiotropic potential of genistein to regulate key cellular pathways and development of efficient drug delivery system will bring us a step towards designing better chemotherapeutics.

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Section: Introductionmentioning

confidence: 99%

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

et al. 2021

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“…Flow rates were found to be inadequate for the necessary tableting technological parameters. Granules prepared by wet granulation exhibited a marked improvement in flow properties and scale of flowability of the soy extract and its formulations was according to USP35 (▶table 1) [69].…”

Section: Solid Oral Dosage Formmentioning

confidence: 99%

An Overview on Genistein and its Various Formulations

et al. 2018

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Genistein is the natural isoflavone and a phytoestrogen with a broad range of pharmacological properties, such as tyrosine and topoisomerase inhibition. It also induces apoptosis and cell proliferation inhibition, differentiates cancer cells. Added health benefits include the reduction of osteoporosis by suppressing osteoclasts and lymphocyte functions, decreased the risk of cardiovascular attacks and relieved postmenopausal problems. Genistein traditionally used in Chinese and Ayurvedic medicine and are found to be associated with lower risk of breast, prostate and lung cancer. Numerous factors comprising genetic, epigenetic and transcriptomic alterations are evidenced to be responsible for breast, prostate and lung cancer. In present review, an overview on genistein, the various analytical methods and drug delivery approaches to determine genistein in the formulations are discussed. It may help to develop novel formulations with better solubility and bioavailability of genistein. The tumor cell scan may be targeted to form a stable genistein formulation.

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“…Studies claim that they bind to the estrogen receptor and can affect the generation of estrogen-induced responses. Apart from this, they are used for the prevention of bone diseases like osteoporosis or diseases connected to heart [ 1 – 3 ]. The predominant isoflavone, Genistein has been characterized for its properties thoroughly.…”

Section: Introductionmentioning

confidence: 99%

“…The main problem with Isoflavones like Genistein, Daidzein, Glycitein etc. is that they have poor water solubility along with high membrane permeability (Class II drugs in BCS) [1,[29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Genistein as a dietary supplement; formulation, analysis and pharmacokinetics study

Mamagkaki¹,

Bouris²,

Parsonidis³

et al. 2021

PLoS ONE

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The objective of this study is to improve and optimize the formulation of Genistein in capsules in order to result in a better pharmacokinetic profile comparing to existing commercial products. In order to do this, five different formulations of Genistein capsules were developed and examined by reviewing their disintegration and dissolution properties. Furthermore, flowability of the powder along with potent incompatibilities between Genistein and its excipients were monitored through their thermal properties. The final formulation of Genistein was quantified using HPLC analysis and then its stability was evaluated thoroughly in real time and accelerated conditions. Finally, with the target to have a product with actual results, in vitro and in vivo studies were conducted. The final product proved to have better results in disintegration and dissolution. Moreover, R.G.C.C.’s capsules exhibited enhanced action in human cell lines as well as impressive pharmacokinetic results in animal models. The in vitro results showed an advantage of the R.G.C.C. product compared to the commercial one, whereas its maximum concertation in vivo was determined 34% higher than the commercial one.

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Preparation and characterization of solid oral dosage forms containing soy isoflavones

Cited by 6 publications

References 12 publications

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

An Overview on Genistein and its Various Formulations

Genistein as a dietary supplement; formulation, analysis and pharmacokinetics study

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