An Overview on Genistein and its Various Formulations

Abstract

Genistein is the natural isoflavone and a phytoestrogen with a broad range of pharmacological properties, such as tyrosine and topoisomerase inhibition. It also induces apoptosis and cell proliferation inhibition, differentiates cancer cells. Added health benefits include the reduction of osteoporosis by suppressing osteoclasts and lymphocyte functions, decreased the risk of cardiovascular attacks and relieved postmenopausal problems. Genistein traditionally used in Chinese and Ayurvedic medicine and are found to be associated with lower risk of breast, prostate and lung cancer. Numerous factors comprising genetic, epigenetic and transcriptomic alterations are evidenced to be responsible for breast, prostate and lung cancer. In present review, an overview on genistein, the various analytical methods and drug delivery approaches to determine genistein in the formulations are discussed. It may help to develop novel formulations with better solubility and bioavailability of genistein. The tumor cell scan may be targeted to form a stable genistein formulation.

Antioxidant Activities of Genistein: A Review

“…), Fava beans (Vicia faba), Psoralea (Psoralea corylifolia), and Kudzu (Pueraria lobata) [13]. The genistein content of various fruits, nuts, and vegetables can vary widely [14]. Like other plant constituents, such as lignans, which have an estrogenic effect, genistein is a typical example of a phytoestrogen compound.…”

Phytoestrogens in treatment of climacteric syndrome as an alternative to menopausal hormone therapy

“…Изофлавоны положительно влияют на уплотнение костной ткани [43][44][45]. Генистеин -главный ФЭ сои подавляет остеокласты и лимфоциты, за счет чего происходит подавление прогрессирования остеопороза [46]. При исследованиях на мышах было выявлено положительное влияние генистеина на микроархитектуру проксимального отдела большеберцовой кости и значительное уменьшение остеокальцина в сыворотке крови и Са 2+ в моче [47]; однако метаболизм ФЭ в организме разных видов живых существ различен, что оставляет неоднозначным возможность проецирования результатов экспериментальных исследований на человека.…”

Therapeutic Potential of the Natural Compound S-Adenosylmethionine as a Chemoprotective Synergistic Agent in Breast, and Head and Neck Cancer Treatment: Current Status of Research

“…Genistein, the most common and well-known isoflavone produced in soya with potential beneficial effects on human health and possible therapeutic application in a wide range of diseases, including cancer [ 67 ] in combination with Doxo exerted a synergistic effect on MCF-7/Adr cells, a Doxo-resistant breast cancer cell line, through a mechanism involving increase in the intracellular accumulation of Doxo and downregulation of the human epidermal growth factor receptor 2/neu, a proto oncogene whose overexpression in breast cancer has been associated to chemotherapy resistance [ 48 ].…”