Chemical constituents and biological activities of species of Justicia: a review

Abstract

Abstract:The Acanthaceae family is an important source of therapeutic drugs, and the ethnopharmacological knowledge of this family requires urgent documentation as several of its species are near extinction. Justicia is the largest genus of Acanthaceae, with approximately 600 species. The present work provides a review addressing the chemistry and pharmacology of the genus Justicia. In addition, the biological activities of compounds isolated from the genus are also covered. The chemical and pharmacological information in the present work may inspire new biomedical applications for the species of Justicia, considering atom economy, the synthesis of environmentally benign products without producing toxic by-products, the use of renewable sources of raw materials, and the search for processes with maximal efficiency of energy.

Structure Activity Relationship (SAR) of Some Benzoic Acid Derivatives from Plant Origin that Exhibit Anti-Sickling Properties in vitro - (Review)

“…Some of them exhibited anti-sickling properties in vitro. These include Piper guineensis, Pterocarpa osun, Eugenia caryophyllala and Sorghum bicolor [21]; Fagara zanthoxyloides [22]; Cajanus cajan [23]; Vigna unguiculata [24]; Carica papaya [25,26]; and Justicia secunda ( [27,28].…”

Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats

“…The genus Justicia, named after the 18 th -century Scottish botanist James Justice, belongs to the large family of Acanthaceae consisting of about 600 species of herbs and shrubs native to the tropics and subtropics (Corrêa and Alcântara, 2012;Durkee, 1986). J. carnea (Justicia carnea) is a flowering plant, widely distributed in various parts of Africa.…”

Pharmacognostic Screening Studies of Justicia Gendarussa Burm. Leaves Found in Dehradun District of Uttarakhand

“…According to Indian and Chinese system of traditional medicine, the roots and leaves are enjoined to treat fever, respiratory disorders, hemiplegia, arthritis, muscle pain, rheumatism, headache, digestive tract problems, and in some cases of mental illness [2,3]. From the literature review, the plant is reported to have the potential antioxidant [4,5], antimicrobial [5], anti-inflammatory [6], antinociceptive [6], antiarthritic [3], antifungal [7], antiangiogenic [8], analgesic [9], antianxiety [1], hepatoprotective [10], antibacterial [11], anticancer [12], anthelmintic [13], cytotoxic [14] and antiviral activities [15]. It is also used to treat the conditions such as amenorrhea and dysmenorrhea [16].…”

“…It is also used to treat the conditions such as amenorrhea and dysmenorrhea [16]. The whole plant is reported to contain flavonoids [17], steroids [15,18], alkaloids, phenolics, tannins and saponins [18]. Some important phytoconstituents are apigenin, vitexin, stigmasterol, campesterol, sitosterol [15], naringenin, kaempferol [14] and aromadedrin [19].…”

“…The whole plant is reported to contain flavonoids [17], steroids [15,18], alkaloids, phenolics, tannins and saponins [18]. Some important phytoconstituents are apigenin, vitexin, stigmasterol, campesterol, sitosterol [15], naringenin, kaempferol [14] and aromadedrin [19]. As this plant is having diverse therapeutic uses and lacking in standardization parameters, the present investigation was carried out to evaluate the leaves of J. gendarussa for various pharmacognostic parameters which will be useful in its authentication and the preparation of monograph in the future.…”