Assessment of antinociceptive and anti-inflammatory activities of Porophyllum ruderale (Jacq.) Cass., Asteraceae, aqueous extract

Lima, Gabrielle Mendes; Bonfim, Rangel Rodrigues; Silva, Mônica Rodrigues da; Thomazzi, Sara Maria; Santos, Márcio Roberto Viana dos; Quintans‐Júnior, Lucindo José; Bonjardim, Leonardo Rigoldi; Araújo, Adriano Antunes de Souza

doi:10.1590/s0102-695x2011005000051

Cited by 11 publications

(4 citation statements)

References 17 publications

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“…Therefore, the test can be used to clarify the possible mechanism of antinociceptive effect of a proposed analgesic drug. 24 Centrally acting drugs such as opioids inhibit both phases equally but peripherally acting drugs such as aspirin, indomethacin and dexamethasone only inhibit the late phase. The early phase is short-lived and initiates immediately after injection, being characterized by C-fiber activation due to peripheral stimuli.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive activity of Euadenia trifoliolata (Schum. & Thonn.) Oliv. leaves and roots in mice

Sofidiya

Oloruntola

Sofola

et al. 2016

Journal of Traditional and Complementary Medicine

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The leaves and roots of Euadenia trifoliolata are used in Nigeria traditional medicine for the treatment of ear ache, head ache and inflammation. The aim of the study was to evaluate the antinociceptive activity of ethanolic extract of the leaves (EL) and roots (ER) of E. trifoliolata in mice. Oral toxicity testing was performed using OECD guidelines. Antinociceptive effect was studied in mice using acetic acid-induced writhing, formalin, tail immersion and hot plate tests. Total polyphenolic contents were determined using standard methods. No mortality was recorded 24 h after oral administration of both EL and ER up to 5000 mg/kg. At the dose of 50, 100 and 200 mg/kg, administration of EL and ER resulted in significant reduction in the number of writhes compared to control. The percentage inhibition of writhings was calculated as 35.67%, 46.71% and 67.94% (EL) and 55.41%, 57.32% and 72.61% (ER), respectively. In hot plate test, EL and ER showed statistically significant antinociceptive effect, although low percentage inhibition (<50%) was recorded for ER at all the doses tested. Only EL (100 and 200 mg/kg) significantly (p < 0.001) increased the reaction time in tail immersion test. Both extracts significantly (p < 0.001) reduced the licking time in both phases of formalin test compared to control. The content of total phenolic, flavonoid and proanthocyanidin varies between the two extracts and may be the basis of the observed antinociceptive effect. The results indicate antinociceptive activity for the leaves and roots of E. trifoliolata, with the extract of the leaves showing better activity.

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Section: Discussionmentioning

confidence: 99%

Antinociceptive activity of Euadenia trifoliolata (Schum. & Thonn.) Oliv. leaves and roots in mice

Sofidiya

Oloruntola

Sofola

et al. 2016

Journal of Traditional and Complementary Medicine

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“…Experimental studies have shown that some phytotherapeutic agents are effective in accelerating the healing of burns [ 24 , 25 ]. P. ruderale is used in the folk medicine for cicatrization and its anti-inflammatory properties and cicatrizing activity [ 26 ]. Similarly, many experimental studies have found beneficial results with the use of low-level laser irradiation on burn wound healing [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Activity of Porophyllum ruderale leaf extract and 670-nm InGaP laser during burns repair in rats

Jácomo¹,

Velozo²,

Lotti³

et al. 2015

BMC Complement Altern Med

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BackgroundIn this study, we investigated the effects of an extract of the leaves of Porophyllum ruderale and laser irradiation on the healing of burns.MethodsSeventy-two rats were divided in four groups: untreated controls, treated with laser irradiation, treated with P. ruderale and treated with both P. ruderale and laser irradiation. Burns were produced with a metal plate on the backs of the animals. Wound samples were collected for structural and morphometric analyses and to quantify the expression of TGF-β1 and VEGF.ResultsLaser irradiation increased the number of fibroblasts, collagen fibers and newly formed vessels and decreased the number of granulocytes at the site of the wounds. Densitometric analysis revealed a significant increase in the expression of TGFβ-1 in the wounds treated with laser irradiation and with the P. ruderale extract at the beginning of the healing process and a decreased during the experimental period. The expression of VEGF was highlighted in the lesions irradiated with laser alone.ConclusionInspite of not showing a beneficial effect on the laser combination with the P. ruderale extract, when the laser was used separately, a positive effects to enhance the healing of second-degree burns was promoted. P. ruderale was effective in decreasing the granulocytes during the repair process indicating a possible anti-inflammatory action of this extract of native flora, widely used in folk medicine, but little studied experimentally.

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“…Furthermore, P. ruderalle is used in folk medicine in Brazil for leishmaniasis, closing wounds, general pain, and internal bruising [24]. Some pharmacological properties have also been described for this plant, such as antioxidant, antimicrobial, anti-nociceptive, anti-inflammatory and antispasmodic activity [23,[25][26][27][28][29][30]. Due to the diuretic, anti-inflammatory and antioxidant properties of papaloquelite, and the close relationship either these biological activities and the development of kidney disease, this plant could be an important source of compounds for the treatment of KAI.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective Activity of Papaloquelite (Porophyllum ruderale) in Thioacetamide-Induced Injury Model

Vázquez-Atanacio

Bautista

González-Cortazar

et al. 2022

Plants

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Acute kidney injury and impaired kidney function is associated with reduced survival and increased morbidity. Porophyllum ruderale is an edible plant endemic to Mexico used in Mexican traditional medicine. The aim of this study was to evaluate the nephroprotective effect of a hydroalcoholic extract (MeOH:water 70:30, v/v) from the aerial parts of P. ruderale (HEPr). Firstly, in vitro the antioxidant and anti-inflammatory activity of HEPr was determined; after the in vivo nephroprotective activity of HEPr was evaluated using a thioacetamide-induced injury model in rats. HEPr showed a slight effect on LPS-NO production in macrophages (15% INO at 40 µg/mL) and high antioxidant activity in the ferric reducing antioxidant power (FRAP) test, followed by the activity on DPPH and ABTS radicals test (69.04, 63.06 and 32.96% of inhibition, respectively). In addition, values of kidney injury biomarkers in urine (urobilinogen, hemoglobin, bilirubin, ketones, glucose, protein, pH, nitrites, leukocytes, specific gravity, and the microalbumin/creatinine) and serum (creatinine, urea, and urea nitrogen) of rats treated with HEPr were maintained in normal ranges. Finally, 5-O-caffeoylquinic, 4-O-caffeoylquinic and ferulic acids; as well as 3-O-quercetin glucoside and 3-O-kaempferol glucoside were identified by HPLC as major components of HEPr. In conclusion, Porophyllum ruderale constitutes a source of compounds for the treatment of acute kidney injury.

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Assessment of antinociceptive and anti-inflammatory activities of Porophyllum ruderale (Jacq.) Cass., Asteraceae, aqueous extract

Cited by 11 publications

References 17 publications

Antinociceptive activity of Euadenia trifoliolata (Schum. & Thonn.) Oliv. leaves and roots in mice

Antinociceptive activity of Euadenia trifoliolata (Schum. & Thonn.) Oliv. leaves and roots in mice

Activity of Porophyllum ruderale leaf extract and 670-nm InGaP laser during burns repair in rats

Nephroprotective Activity of Papaloquelite (Porophyllum ruderale) in Thioacetamide-Induced Injury Model

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