Activity of Porophyllum ruderale leaf extract and 670-nm InGaP laser during burns repair in rats

Jácomo, Ana Cristina Justino; Velozo, Karina de Andrade; Lotti, Raquel Gabilan; Neves, Lia Mara Grosso; Gaspi, Fernanda de Gaspari de Oliveira; Esquisatto, Marcelo Augusto Marretto; Amaral, Maria Esméria Corezola do; Mendonça, Fernanda Aparecida Sampaio; Santos, Gláucia Maria Tech dos

doi:10.1186/s12906-015-0805-2

Cited by 15 publications

(9 citation statements)

References 42 publications

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“…Although several studies on laser photobiomodulation ensured the improvement of scar repair, specially secondintention wound healing, some studies compared the clinical efficacy of laser application with topical herbal medicine (Catarino et al, 2015;Jácomo et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

et al. 2016

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Impaired wound healing represents a serious complication in some pathologies and the use of plant extracts has proved to improve tissue repair. The objectives of this study were to evaluate the healing potential of the ointment of Sebastiana hispida compared with Aluminum-Gallium Indium-Phosphide Laser (InGaAlP) in surgically induced wounds in rats and to perform the phytochemical analysis. The phytochemical analysis was performed in the classic way and also by HPLC. A controlled study was developed with 80 rats (200-250 g) in which a linear excision was performed in the dorsal region after shaving, measuring 2 cm × 1 cm (epidermis and dermis) exposing the muscle fascia. The rats were randomly divided into four groups of twenty animals each. The experimental groups (n = 5) were G1 (Saline); G2 (crude methanol plant extract 2% + Carbopol Gel 98%); G3 (crude methanol plant extract 2% + lanolin/vaseline) and G4 (laser). The incision healing processes were monitored during 3, 7, 14 and until 21 days after excision. The histologic parameters evaluated were Collagen fiber types, microscopic examination and neovascularization. There was a significant increase in the deposition of collagen fibers, as evidenced by a better organized epithelial tissue, keratinized and showing greater proliferation of new blood vessels in the inflammatory phase in the group treated with both the extract and laser. The results were correlated to the phenolic derivatives found after qualitative and quantitative analysis. These compounds were considered responsible for the healing process. The topical treatment with S. hispida leaves, in the two different formulations, was more effective than the application of the laser (Ingan ALP) 660 nm in the model used.Keywords: laser therapy, tissue repair, inflammatory cells, medicinal plants. Potencial cicatrizante da pomada de Sebastiania hispida (Mart.) Pax (Euphorbiaceae) comparado ao laser de baixa potência ResumoA cicatrização deficiente representa uma complicação grave em algumas patologias e o uso de extratos de plantas tem demonstrado melhora no processo de reparação tecidual. O objetivo deste estudo foi avaliar o potencial cicatrizante da pomada de Sebastiania hispida comparado ao Laser Indio Phosphide-Gallium-Aluminum (InGaAlP) em feridas cutâneas induzidas cirurgicamente em ratos e realizar analise fitoquímica. A análise fitoquímica foi via clássica e por CLAE. O experimento foi desenvolvido com 80 ratos (200-250 g), divididos aleatoriamente em quatro grupos (n = 5): G1 (salina); G2 (extrato bruto metanólico 2% + Carbopol Gel 98%); G3 (extrato bruto metanólico 2% + lanolina/ vaselina) e G4 (laser). Após a tricotomia da região dorsal realizou uma excisão linear, medindo 2 cm × 1 cm (epiderme e derme), expondo a fáscia muscular. Em sequência os tratamentos e o monitoramento do processo de cicatrização das feridas cirúrgicas ocorreu nos tempos de: 3, 7, 14 e até 21 dias após a excisão. Os parâmetros histológicos avaliadosBraz.

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Section: Discussionmentioning

confidence: 99%

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

et al. 2016

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“…Two different types of laser (670-InGaP and 830-nm GaAlAs) are used for Chiarotto et al [8] in the treatment of second-degree burns in rats and it was observed that the laser 670-nm InGaP was more effective in increasing the numbers fibroblast at the injury site. Other authors have also demonstrated the beneficial effects of low intensity laser in tissue repair using 670nm [6,23,24].…”

Section: Introductionmentioning

confidence: 95%

Differing energy densities with laser 670 nm InGaP controls inflammation and collagen reorganization in burns

Maligieri

Neves

Morais

et al. 2017

Burns

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“…An extract of the leaves of Porophyllum ruderale and laser irradiation on the healing of burns were effective in decreasing the granulocytes during the repair process indicating a possible anti-inflammatory action of this extract of native flora [116].…”

Section: Other Plant Species Used In Wound Healingmentioning

confidence: 93%

Natural Compounds for Wound Healing

Georgescu¹,

Marinas²,

Popa³

et al. 2016

Worldwide Wound Healing - Innovation in Natural and Conventional Methods

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Many plants or plant-derived compounds with high levels of antioxidants and antiinflammatory, immunomodulatory, and antimicrobial properties could be of great benefit for wound healing. Several studies have documented the use of plant extracts for the development of bioactive wound dressings. The purpose of this chapter is to give an update about the vegetal and bee products, which can be used as bioactive substances in wound dressings or in other formulations for wound healing. The adverse effects of plant and bee extracts, such as contact allergies, are also presented. In order to better exploit the huge reservoir of pharmacologically active plant-derived compounds and extracts, standardized methodology and clinical trials are necessary to give more concrete evidence supporting the use of traditional medicine in wound management.

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Activity of Porophyllum ruderale leaf extract and 670-nm InGaP laser during burns repair in rats

Cited by 15 publications

References 42 publications

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

Differing energy densities with laser 670 nm InGaP controls inflammation and collagen reorganization in burns

Natural Compounds for Wound Healing

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