Pharmacological effects of the monoterpene alpha,beta-epoxy-carvone in mice

Abstract

RESUMO: "Efeitos farmacológicos do monoterpeno α,β-epoxi-carvona em camundongos". O monoterpeno α,β-epóxi-carvona (EC) nas doses de 200, 300 e 400 mg/kg administrado por via i.p. em camundongos diminuiu signifi cativamente a atividade motora dos animais, quando comparado aos controles, até 120 minutos após a administração. As doses de 300 e 400 mg/kg induziram um aumento signifi cativo do tempo de sono dos animais não alterando, no entanto, a sua latência. O EC na dose de 400 mg/kg induziu uma redução no tempo de permanência dos animais na barra giratória (teste do rotarod). Os resultados sugerem um possível efeito central.Unitermos: Efeito farmacológico, óleo essencial, monoterpeno, α,β-epóxi-carvona, camundongos. ABSTRACT:The monoterpene α,β-epoxy-carvone (EC) in doses of 200, 300 or 400 mg/kg injected by i.p. route in mice caused a signifi cant decrease in the motor activity of animals when compared with the control group, up to 120 minutes after the administration. The doses of 300 or 400 mg/kg had induced a signifi cant increase of in the sleeping time of animals not having modifi ed, however, the latency. The EC in the dose of 400 mg/kg reduced the remaining time of the animals on the rotating rod (Rotarod test). These results suggest a possible central effect.

Antinociceptive effect of citronellal in mice

“…presented behavioral alterations, such as decrease of spontaneous activity, palpebral ptosis, ataxia, analgesia, and sedation. These effects were dose-dependent and showed possible evidence that the effects on the CNS are similar to those of drugs that reduce central activity (Morais et al, 2004;De Sousa et al, 2007a).…”

“…They are found in edible as well as medicinal plants with a therapeutic property (Carneiro et al, 1997). Additionally, monoterpenes and their derivative compounds exhibit several types of pharmacological properties, such as anxiolytic (Silva et al, 2007), antinociceptive (De Sousa et al, 2007b), sedative (Elisabetsky et al, 1995;De Sousa et al, 2006a, 2007a, antidepressant (De Sousa et al, 2006b), and anticonvulsant (Viana et al, 2000;De Sousa et al, 2006c, 2007c. In this regard, citronellal (3,7-dimethyl-6-octen-1-al) as a monoterpene is a major component of the essential oils in various aromatic species, such as Cymbopogon winterianus Jowitt (Java citronella) (Quintans-Júnior et al, 2008), Corymbia citriodora (Hook.)…”

Terpenóides com atividade sobre o Sistema Nervoso Central (SNC)

“…Compostos como linalool, limoneno e citronelol possuem ação anticonvulsivante, enquanto mentol e mirceno, atividade analgésica. Muitos derivados monoterpênicos têm demonstrado atividades sobre o SNC, incluindo sedativa, antinociceptiva e antidepressiva (Pergentino de Souza et al, 2007;Sousa et al, 2007;Perazzo et al, 2007Perazzo et al, , 2008Leite et al, 2008). O presente trabalho propõe uma revisão sobre terpenos com ações descritas no SNC, enfocando principalmente os sistemas neurotransmissores relacionados a estas.…”

Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats

“…Popularly, they are used in the control of emotions and mood, for their sedative, anxiolytic (Lehrner et al, 2000), antidepressant effects (Komori et al, 1995a;De-Souza et al, 2006), and anticonvulsant (Viana et al, 2000;Sousa et al, 2007) among others (Oliveira et al, 2006;Ferronatto et al, 2007;Oliveira et al, 2007;Barbosa-Filho et al, 2008;Sousa et al, 2008). Some studies suggest that they act by modulating the central neurotransmission (Komiya et al, 2006).…”