2009
DOI: 10.1590/s0102-695x2009000100024
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Terpenóides com atividade sobre o Sistema Nervoso Central (SNC)

Abstract: RESUMO:Os terpenóides constituem um vasto grupo de metabólitos secundários com ações sobre o SNC, destacando-se suas atividades sedativa, ansiolítica, antinociceptiva, anticonvulsivante, pró-convulsivante e alucinógena. Neste trabalho foi realizada uma revisão bibliográfica sobre terpenóides com ações descritas no SNC, enfocando moléculas e sistemas neurotransmissores relacionados com sua atividade. As substâncias abordadas encontram-se divididas em mono, sesqui, di, tri e meroterpenóides e incluem compostos i… Show more

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Cited by 39 publications
(12 citation statements)
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“…It has been observed that many monoterpenes present a reduction of locomotor activity (Passos et al 2009) by an inhibitory effect on the CNS or by a non-specific muscle relaxation effect (Melo et al 2011b). Thus, these activities can reduce the motor coordination response, invalidating the nociceptive behavioral tests (De Sousa et al 2006b).…”
Section: Discussionmentioning
confidence: 99%
“…It has been observed that many monoterpenes present a reduction of locomotor activity (Passos et al 2009) by an inhibitory effect on the CNS or by a non-specific muscle relaxation effect (Melo et al 2011b). Thus, these activities can reduce the motor coordination response, invalidating the nociceptive behavioral tests (De Sousa et al 2006b).…”
Section: Discussionmentioning
confidence: 99%
“…They cause changes in behavior and often culminate in addiction. The drugs can be divided according to their action, namely depressants (barbiturates, alcohol, and opiates), stimulants (nicotine, cocaine, crack cocaine, and amphetamines), hallucinogens (lysergic acid, LSD), impairing drugs (hemp derivatives), and mixed-acting drugs (ecstasy) [1][2][3][4][5][6][7][8][9].…”
Section: Illicit Drugsmentioning
confidence: 99%
“…Studies have suggested that the CNS depression and the non-specific muscle relaxation effects can reduce the response of motor coordination and might invalidate the behavioral tests [43][44][45]. However, previous studies with CT, using the same doses as the present study, did not show any interference on motor coordination of the animals in the rota-rod test and in the spontaneous locomotor activity [17,42].…”
Section: Discussionmentioning
confidence: 44%