Terpenóides com atividade sobre o Sistema Nervoso Central (SNC)

Passos, Carolina dos Santos; Arbo, Marcelo Dutra; Rates, Stela Maris Kuze; Poser, Gilsane Lino von

doi:10.1590/s0102-695x2009000100024

Cited by 41 publications

(15 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been observed that many monoterpenes present a reduction of locomotor activity (Passos et al 2009) by an inhibitory effect on the CNS or by a non-specific muscle relaxation effect (Melo et al 2011b). Thus, these activities can reduce the motor coordination response, invalidating the nociceptive behavioral tests (De Sousa et al 2006b).…”

Section: Discussionmentioning

confidence: 99%

Carvacrol attenuates mechanical hypernociception and inflammatory response

Guimarães

Xavier

Santana

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

149

104

View full text Add to dashboard Cite

Carvacrol is a phenolic monoterpene present in the essential oil of the family Lamiaceae, as in the genera Origanum and Thymus. We previously reported that carvacrol is effective as an analgesic compound in various nociceptive models, probably by inhibition of peripheral mediators that could be related with its strong antioxidant effect observed in vitro. In this study, the anti-hypernociceptive activity of carvacrol was tested in mice through models of mechanical hypernociception induced by carrageenan, and the involvement of important mediators of its signaling cascade, as tumor necrosis factor-alpha (TNF-α), prostaglandin E(2) (PGE(2)), and dopamine, were assessed. We also investigated the anti-inflammatory effect of carvacrol on the model of carrageenan-induced pleurisy and mouse paw edema, and the lipopolysaccharide (LPS)-induced nitrite production in murine macrophages was observed. Systemic pretreatment with carvacrol (50 or 100 mg/kg; i.p.) inhibited the development of mechanical hypernociception and edema induced by carrageenan and TNF-α; however, no effect was observed on hypernociception induced by PGE(2) and dopamine. Besides this, carvacrol significantly decreased TNF-α levels in pleural lavage and suppressed the recruitment of leukocytes without altering the morphological profile of these cells. Carvacrol (1, 10, and 100 μg/mL) also significantly reduced (p < 0.001) the LPS-induced nitrite production in vitro and did not produce citotoxicity in the murine peritoneal macrophages in vitro. The spontaneous locomotor activity of mice was not affected by carvacrol. This study adds information about the beneficial effects of carvacrol on mechanical hypernociception and inflammation. It also indicates that this monoterpene might be potentially interesting in the development of novel tools for management and/or treatment of painful conditions, including those related to inflammatory and prooxidant states.

show abstract

Section: Discussionmentioning

confidence: 99%

Carvacrol attenuates mechanical hypernociception and inflammatory response

Guimarães

Xavier

Santana

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

149

104

View full text Add to dashboard Cite

show abstract

“…They cause changes in behavior and often culminate in addiction. The drugs can be divided according to their action, namely depressants (barbiturates, alcohol, and opiates), stimulants (nicotine, cocaine, crack cocaine, and amphetamines), hallucinogens (lysergic acid, LSD), impairing drugs (hemp derivatives), and mixed-acting drugs (ecstasy) [1][2][3][4][5][6][7][8][9].…”

Section: Illicit Drugsmentioning

confidence: 99%

Voltammetric determination of Δ9-THC in glassy carbon electrode: An important contribution to forensic electroanalysis

Balbino

Menezes

Eleotério

et al. 2012

Forensic Science International

View full text Add to dashboard Cite

A new voltammetric method for the determination of Δ(9)-tetrahydrocannabinol (Δ(9)-THC) is described. The voltammetric experiments were accomplished in N-N dimethylformamide/water (9:1, v/v), using tetrabutylammonium tetrafluoroborate (TBATFB) 0.1mol/L as supporting electrolyte and a glassy carbon disk electrode as the working electrode. The anodic peak current was observed at 0.0V (vs. Ag/AgCl) after a 30s pre-concentration step under an applied potential of -1.2V (vs. Ag/AgCl). A linear dependence of Δ(9)-THC detection was obtained in the concentration range 2.4-11.3ng/mL, with a linear correlation coefficient of 0.999 and a detection limit of 0.34ng/mL. The voltammetric method was used to measure the content of Δ(9)-THC in samples (hemp and hashish) confiscated by the police. The elimination of chemical interferences from the samples was promptly achieved through prior purification using the TLC technique, by employing methanol/water (4:1, v/v) as the mobile phase. The results showed excellent correlation with results attained by HPLC.

show abstract

“…Studies have suggested that the CNS depression and the non-specific muscle relaxation effects can reduce the response of motor coordination and might invalidate the behavioral tests [43][44][45]. However, previous studies with CT, using the same doses as the present study, did not show any interference on motor coordination of the animals in the rota-rod test and in the spontaneous locomotor activity [17,42].…”

Section: Discussionmentioning

confidence: 44%