Citronellol, a natural acyclic monoterpene, attenuates mechanical hyperalgesia response in mice: Evidence of the spinal cord lamina I inhibition

Brito, Renan Guedes de; Santos, Priscila L.; Quintans, Jullyana S.S.; Júnior, Waldecy de Lucca; Araújo, Adriano A. S.; Saravanan, S.; Menezes, Irwin Rose Alencar de; Coutinho, Henrique Douglas Melo; Quintans‐Júnior, Lucindo J.

doi:10.1016/j.cbi.2015.06.039

Cited by 22 publications

(5 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, several chemical and nutritional studies have reported that acyclic fatty alcohols obtained from waxy materials of different origins exert beneficial effects on physiology [ 13 , 41 ]. For example, fixed oil has been described as having beneficial effects on osteoarthritis [ 42 ], hyperlipidemia [ 43 ], hyperalgesia [ 44 ], and inflammation [ 45 , 46 ]. However, little research has dealt with the pharmacological effects of phytol (3,7,11,15-tetramethylhexadec-2-en-1-ol), the main compound (167.59 ± 1.81 mg/kg of HSO) present in the acyclic fatty alcohol fraction isolated from HSO [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

Acyclic Diterpene Phytol from Hemp Seed Oil (Cannabis sativa L.) Exerts Anti-Inflammatory Activity on Primary Human Monocytes-Macrophages

Claro-Cala

Grao‐Cruces

Toscano

et al. 2022

Foods

View full text Add to dashboard Cite

Seeds from non-drug varieties of hemp (Cannabis sativa L.) have been used for traditional medicine, food, and fiber production. Our study shows that phytol obtained from hemp seed oil (HSO) exerts anti-inflammatory activity in human monocyte-macrophages. Fresh human monocytes and human macrophages derived from circulating monocytes were used to evaluate both plasticity and anti-inflammatory effects of phytol from HSO at 10–100 mM using FACS analysis, ELISA, and RT-qPCR methods. The quantitative study of the acyclic alcohol fraction isolated from HSO shows that phytol is the most abundant component (167.59 ± 1.81 mg/Kg of HSO). Phytol was able to skew monocyte-macrophage plasticity toward the anti-inflammatory non-classical CD14+CD16++ monocyte phenotype and toward macrophage M2 (CD200Rhigh and MRC-1high), as well as to reduce the production of IL-1β, IL-6, and TNF-α, diminishing the inflammatory competence of mature human macrophages after lipopolysaccharide (LPS) treatment. These findings point out for the first time the reprogramming and anti-inflammatory activity of phytol in human monocyte-macrophages. In addition, our study may help to understand the mechanisms by which phytol from HSO contributes to the constant and progressive plasticity of the human monocyte-macrophage linage.

show abstract

Section: Resultsmentioning

confidence: 99%

Acyclic Diterpene Phytol from Hemp Seed Oil (Cannabis sativa L.) Exerts Anti-Inflammatory Activity on Primary Human Monocytes-Macrophages

Claro-Cala

Grao‐Cruces

Toscano

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…Additionally, it was also evaluated the involvement of the spinal cord lamina I in this antihyperalgesic effect. The immunofluorescence protocol showed that CTOL significantly decreased the average number of neurons presenting Fos protein, indicating that the action of CTOL on mechanical hyperalgesia occurs, at least in part, via inhibition of the spinal cord lamina I [ 141 ].…”

Section: Resultsmentioning

confidence: 99%

Analgesic-Like Activity of Essential Oil Constituents: An Update

Sá

Lima

Nóbrega

et al. 2017

IJMS

View full text Add to dashboard Cite

The constituents of essential oils are widely found in foods and aromatic plants giving characteristic odor and flavor. However, pharmacological studies evidence its therapeutic potential for the treatment of several diseases and promising use as compounds with analgesic-like action. Considering that pain affects a significant part of the world population and the need for the development of new analgesics, this review reports on the current studies of essential oils’ chemical constituents with analgesic-like activity, including a description of their mechanisms of action and chemical aspects.

show abstract

“…Essential oils of Cymbopogon are rich sources of acyclic monoterpenes (Bergman et al, 2023). Citronellol, a monoterpene alcohol, has vasorelaxant, anticonvulsive, analgesic, antibacterial and anti-inflammatory activity (de Sousa et al, 2006;Brito et al, 2012;Brito et al, 2015). Elemol is a sesquiterpene alcohol with a sweet smell of green wood which has been proven to have antifungal, repellent and insecticidal action (Carroll et al, 2010;SeonHong et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Research Article Chemical profile of essential oil in four <i>Cymbopogon</i> species grown in southern Brazil

Prochnow,

Santos,

Barros

et al. 2023

Genet. Mol. Res.

View full text Add to dashboard Cite

Essential oils (EO) are substances used by pharmaceutical, cosmetic and food industries. These compounds have useful properties for human health and well-being. Among the species cultivated for production of these substances are those of the genus Cymbopogon. Several species, subspecies, varieties, and sub-varieties are used worldwide, and studies have been conducted to elucidate the chemical features of their EO, mainly for C. citratus and C. winterianus. However, there are still species with great potential that have not yet been fully chemically characterized. In addition, EO composition is influenced by genetic and environmental factors. Along this line, we examined the chemical profile of EO of four species of the genus Cymbopogon (C. citratus, C. distans, C. flexuosus and C. winterianus) grown in southern Brazil. The EO was obtained from fresh leaf tissues by hydrodistillation. Citral was identified as the main component of C. citratus, C. flexuosus, and C. distans, whereas citronellal, citronellol, cisgeraniol and elemol were predominant in C. winterianus. The absence of a large range of compounds was noted in C. distans, which may be useful for the semi-exclusive synthesis of citral and other compounds of interest. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 22 (4): gmr19160 D. Prochnow et al. 2

show abstract

Citronellol, a natural acyclic monoterpene, attenuates mechanical hyperalgesia response in mice: Evidence of the spinal cord lamina I inhibition

Cited by 22 publications

References 42 publications

Acyclic Diterpene Phytol from Hemp Seed Oil (Cannabis sativa L.) Exerts Anti-Inflammatory Activity on Primary Human Monocytes-Macrophages

Acyclic Diterpene Phytol from Hemp Seed Oil (Cannabis sativa L.) Exerts Anti-Inflammatory Activity on Primary Human Monocytes-Macrophages

Analgesic-Like Activity of Essential Oil Constituents: An Update

Research Article Chemical profile of essential oil in four <i>Cymbopogon</i> species grown in southern Brazil

Contact Info

Product

Resources

About