Analgesic-Like Activity of Essential Oil Constituents: An Update

Sá, Rita de Cássia da Silveira e; Lima, Tamires Cardoso; Nóbrega, Flávio Rogério da; Brito, Anna Emmanuela Medeiros de; Sousa, Damião Pergentino de

doi:10.3390/ijms18122392

Cited by 56 publications

(44 citation statements)

References 232 publications

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“…Compounds such as ursolic acid, rosmarinic acid, ferulic acid, caffeic acid, tanshinone IIA, and oleanolic acid, in S. miltiorrhiza could regulate pain targets. Interestingly, we also found that many of the compounds that regulate pain originate from volatile oils/essential oils molecules (de Cassia et al, 2017). Terpene compounds are the main components of volatile oils.…”

Section: Regulatory Effects Of Tcm On Related Targets Of Endometriosimentioning

confidence: 68%

Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology–Based Identification

Zheng

et al. 2020

Front. Pharmacol.

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could also regulate VEGF signaling, toll-like reporter signaling, NF-kB signaling, MAPK signaling, PI3K-Akt signaling, and the HIF-1 signaling pathway, among others. Synergies often exist in herb pairs and herbal prescriptions. In conclusion, we identified some important targets, target pairs, and regulatory networks, using bioinformatics and data mining. The combination of data mining and network pharmacology may offer an efficient method for drug discovery and development from herbal medicines.

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Section: Regulatory Effects Of Tcm On Related Targets Of Endometriosimentioning

confidence: 68%

Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology–Based Identification

Zheng

et al. 2020

Front. Pharmacol.

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“…A review by de Cassia (20) reported, in particular, a significant analgesic activity of menthol in controlling acute and inflammatory pain. This could act in combination with both (-)-α-bisabolol (24), Commiphora myrrha (21), allantoin (20), anethole and licorice (27,43), which display analgesic activity together with anti-inflammatory and wound healing effects.…”

Section: Discussionmentioning

confidence: 99%

“…Tea tree (Melaleuca alternifolia), another plant belonging to this family, is characterized by antifungal (13), anti-inflammatory (14) and anti-bacterial effects (15,16). Furthermore, the extracts from the family of Lamiaceae, including Thymus vulgaris and Mentha piperita, exhibited in vitro antioxidant (17), antifungal and anti-cancer (18,19) activities, as well as analgesic effects against inflammatory pain (20). Similar effects have been reported for Commiphora myrrha (21) and Licorice (Glycyrrhiza glabra) extracts (22).…”

Section: Introductionmentioning

confidence: 99%

“…Similar effects have been reported for Commiphora myrrha (21) and Licorice (Glycyrrhiza glabra) extracts (22). Among isolated compounds, (-)-α-bisabolol, the main component of the EO from Matricaria chamomilla, showed anti-bacterial, anti-mutagenic, anti-inflammatory, analgesic and cicatrizing properties (23,24), while anethole, from Anethum graveolens and Illicium verum, exhibited anesthetic and antioxidant effects (20,25), and decreased the synthesis and the release of several inflammatory mediators, thus explicating antinociceptive activity (26). Allantoin, physiologically present in a human body and in plants, especially in Symphytum officinale leaves, can promote wound healing and stimulate cell mitosis (27,28), displayed analgesic (29), anti-inflammatory and moisturizing effects (27), besides a certain keratolytic activity (30).…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory and wound healing effects of an essential oils-based bioadhesive gel after oral mucosa biopsies: preliminary results

Scotti

Decani

Sardella

et al. 2018

Cell Mol Biol (Noisy-le-grand)

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Post-operative management of patients receiving oral biopsy includes the control of edema, pain, infection, and re-epithelization at the surgical site. This clinical study investigates the topical use of a bioadhesive gel, containing essential oils, to promote wound healing and prevent post-operative pain and infection, avoiding the need for surgical suture and chlorhexidine applications. Ten patients, who needed to receive oral biopsies (≤6 mm in diameter) for the diagnosis of mucosal oral lesions, were enrolled. The bioadhesive gel successfully controlled the post-surgical pain; at 1-week follow-up visit, no signs of infection nor side effects were reported and the surgical sites were completely healed. The bioadhesive gel resulted in a very promising agent for the post-operative management of oral biopsy site, without the need for surgical suture and chlorhexidine applications.

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“…Essential oils are natural products that demonstrate high therapeutic potential against various types of pathologies, including central nervous system (CNS) disorders. Their chemical constituents exhibit various pharmacological activities such as anxiolytic [8], antidepressant [9], analgesic [10], anticonvulsant [11], and inhibitory effects against brain tumor cells [12]. Monoterpenes are compounds commonly found in essential oils that have received much attention as a potential therapy for AD [13].…”

Section: Introductionmentioning

confidence: 99%

(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

Hrițcu

Boiangiu

Morais

et al. 2020

BioMed Research International

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Alzheimer’s disease (AD) could be considered a multifactorial neurodegenerative disorder characterized by the accumulation of the β-amyloid-peptide (Aβ) within the brain leading to cognitive deficits, oxidative stress, and neuroinflammation. The present work was carried out to investigate the neuroprotective effect of (-)-cis-carveol (1% and 3%, for 21 days) against the β-amyloid-peptide 1-42- (Aβ1-42-) induced AD. Twenty-five rats were divided into five groups (n=5/group): the first group—control (sham-operated); the second group—Aβ1-42 (1 mM) that received donepezil treatment (5 mg/kg, as the positive reference drug in the Y-maze and the radial arm maze tests); the third group—Aβ1-42 (1 mM); the fourth and fifth groups—Aβ1-42 (1 mM) that received (-)-cis-carveol treatment groups (1% and 3%). The results of this study demonstrated that (-)-cis-carveol improved Aβ1-42-induced memory deficits examined by using Y-maze and radial arm maze in vivo tests. Also, the biochemical analyses of the hippocampus homogenates showed that (-)-cis-carveol reduced hippocampal oxidative stress caused by Aβ1-42. Our results suggested that the use of (-)-cis-carveol may be suitable for decreasing AD-related symptoms.

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Analgesic-Like Activity of Essential Oil Constituents: An Update

Cited by 56 publications

References 232 publications

Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology–Based Identification

Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology–Based Identification

Anti-inflammatory and wound healing effects of an essential oils-based bioadhesive gel after oral mucosa biopsies: preliminary results

(-)-cis-Carveol, a Natural Compound, Improvesβ-Amyloid-Peptide 1-42-Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus

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